Abstract: The present invention relates to polypeptide consisting of three TNF homology domains of TNF-ligand family members proteins (THD) that specifically bind to the extracellular part of TNFR2, wherein C-terminal and N-terminal reference points are defined by consensus sequences. The THDs are linked by short stretches of further C-terminal and/or N-terminal amino acids of the THD or variants thereof as well as by peptide linkers. These peptides have an improved stability. Furthermore the invention relates to polypeptide multimers comprising several of the polypeptides of the present invention.

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more N protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises a two or more polymerization domains (PD).

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises two or more polymerization domains (PD).

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises two or more polymerization domains (PD).

Abstract: Preparation of aliphatic N,N-dialkyl-substituted amino alcohols of the general formula I ##STR1## from diols of the general formula IIHO--A--OH (II)and secondary amines of the general formula III ##STR2## where A is an aliphatic chain of at least 2 carbon atoms and R.sup.1 and R.sup.2 are alkyl radicals of from 1 to 6 carbon atoms, which may be joined to form a five-membered or six-membered ring--in the liquid phase at elevated temperature and pressure and in the presence of a hydrogenation/dehydrogenation catalyst, hydrogen, and a basic alkali-metal or alkaline-earth-metal compound, where (a) the temperature is from 150.degree. C. to 250.degree. C.; (b) the total pressure is from 40 bar to 250 bar; (c) the hydrogen partial pressure is from 2 bar to 60 bar; (d) the hydrogenation/dehydrogenation catalyst is based on copper; (e) water is present, the mass being from 1% to 20% of the mass of the reaction mixture.

Abstract: N-substituted cyclic amines of the general formula I ##STR1## where A is an alkylene group or a --(CH.sub.2).sub.n --[--O--(CH.sub.2).sub.m ].sub.r group which may be monosubstituted or polysubstituted by radicals R without the radicals R in a defined compound having to be identical, R is alkyl, alkoxyalkyl, unsubstituted or alkyl-substituted or alkoxy-substituted cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, n and m independently of one another are each from 2 to 8 and r is from 1 to 3, the --(CH.sub.2).sub.n --[O--(CH.sub.2).sub.m ].sub.r group consisting of from 5 to 12 members, are prepared by reacting a primary amine of the general formula IIR--NH.sub.

Abstract: A process for the preparation of tertiary alkylamines having a total of up to 9 carbon atoms by reacting a dialkylamine with a C.sub.2 -C.sub.4 -alcohol in the presence of a hydrogenation/dehydrogenation catalyst which contains essentially only copper as the hydrogenating/dehydrogenating catalytic metal is proposed, wherein the reactants(a) are present in the liquid phase,(b) contain alkali metal and/or alkaline earth metal oxides and/or hydroxides and(c) are reacted in a molar ratio of dimethylamine to alcohol of from 1:10 to 10:1 and(d) in the presence of the water formed during the reaction.

Abstract: Trialkylamines are prepared by reacting primary alcohols with ammonia or a primary alkylamine in the presence of a hydrogenation/dehydrogenation catalyst and in the presence of hydrogen by(a) operating in liquid phase(b) using the alcohol in a stoichiometric excess of from 1 to 15 moles per mole of ammonia or primary alkylamine,(c) carrying out the reaction in the presence of the water formed in the course of the reaction, and(d) using a hydrogenation/dehydrogenation catalyst which substantially contains only copper as the catalytically hydrogenating/dehydrogenating metal.

Abstract: Zineb is stabilized by mixing it with calcium oxide in the absence of sulfur.

Abstract: 4-(m,m'-ditert.-butyl-p-hydroxyphenyl)-butan-2-ones are produced by reaction of a 4-hydroxybutanone-(2) with 2,6-ditert.-butylphenol in the presence of a strong acid at elevated temperature. The compounds obtainable by the process, particularly 4-(m,m'-ditert.-butyl-p-hydroxyphenyl)-butane-2-one, are starting materials for the production of dyes, pest control agents and plastics auxiliaries and particularly of stabilizers for polyolefins and polyamides.

Abstract: Amidosulfonic acids are manufactured by reacting ureas first with sulfur trioxide and then with sulfuric acid in the presence of organic solvents. The products are sweeteners, in particular cyclohexylamidosulfonic acid and its calcium, sodium and potassium salts, and starting materials for the manufacture of sweeteners, dyes and pesticides.

Abstract: Novel 4-(m,m'-di-t-butyl-p-hydroxyphenyl)-butyl-2 compounds which are intermediates in the manufacture of dyes, pesticides and plastics auxiliaries, particularly stabilizers for polyolefins and polyamides. When molten, they form specific solvents for alkylphenols and are perfumes or form ingredients of perfume compositions having a fruity odor.

Abstract: Novel 4-(m,m'-di-t-butyl-p-hydroxyphenyl)-butyl-2 diamides of aliphatic, araliphatic, cycloaliphatic or aromatic dicarboxylic acids which are intermediates in the manufacture of dyes, pesticides and plastics auxiliaries, particularly stabilizers for polyolefins and polyamides. When molten, they form specific solvents for alkylphenols and are perfumes or form ingredients of perfume compositions having a fruity odor.

Abstract: A process for the production of high molecular weight .alpha.,.beta.-unsaturated aldehydes by alkylation of the .gamma.-carbon atom of a lower molecular weight .alpha.,.beta.-unsaturated aldehyde with a substituted allyl alcohol which has a chain branching in the 3-position carbon atom or a phenyl radical in the 3-position or of a corresponding allyl alcohol carboxylic ester at elevated temperature in the liquid phase.The products are valuable intermediates for the production of natural substances and odorants.

Abstract: Novel 4-(m,m'-di-t-butyl-p-hydroxyphenyl)-butyl-2 compounds whihc are intermediates in the manufacture of dyes, pesticides and plastics auxiliaries, particularly stabilizers for polyolefins and polyamides. When molten, they form specific solvents for alkylphenols and are perfumes or form ingredients of perfume compositions having a fruity odor.

Abstract: New and valuable herbicide based on 1-phenyl-4-amino-5-chloro (or -5-bromo)-pyridazone-(6) in the form of an aqueous suspension.

Abstract: A process for the production of high molecular weight .alpha.,.beta.-unsaturated aldehydes by alkylation of the .gamma.-carbon atom of a lower molecular weight .alpha.,.beta.-unsaturated aldehyde with a substituted allyl alcohol which has a chain branching in the 4-position carbon atom or a phenyl radical in the 4-position or of a corresponding allyl alcohol carboxylic ester at elevated temperature in the liquid phase.The products are valuable intermediates for the production of natural substances and odorants.

Abstract: A process for the production of .alpha.,.beta.-unsaturated ketones by reaction of an aldehyde with a ketone in the presence of a catalyst consisting essentially of zinc oxide in the liquid phase. The ketones obtained are suitable in some cases as solvents and in some cases as intermediates for the production of valuable odorants, dyes, plastics and especially natural substances.

Abstract: A process for the production of high molecular weight .alpha., .beta.-unsaturated aldehydes by alkylation of the .gamma.-carbon atom of a lower molecular weight .alpha., .beta.-unsaturated aldehyde with a substituted allyl alcohol which has a chain branching in the 3-position carbon atom or a phenyl radical in the 3-position or of a corresponding allyl alcohol carboxylic ester at elevated temperature in the liquid phase.The products are valuable intermediates for the production of natural substances and odorants.

Abstract: A process for the recovery of pure 2-methyl-2-hydroxyheptanone-6 by conversion of impure 2-methyl-2-hydroxyheptanone-6 into 2,2,6-trimethyl 2,3-hydro-4-H-pyran by treatment with an acid which is not volatile under the reaction conditions at a temperature of from 30.degree. to 150.degree.C, purification of the 2,2,6-trimethyl-2,3-hydro-4-H-pyran thus obtained by distillation, reaction of the purified 2,2,6-trimethyl-2,3-hydro-4-H-pyran with water in the presence of an acid ion exchanger and removal of the excess water from the aqueous solution of 2-methyl-2-hydroxyheptanone-6 thus obtained by distillation. 2-methyl-2-hydroxyheptanone-6 is suitable for the production of 2-methyl-2-hydroxy-6-aminoheptane which is effective as a pharmaceutical for conditions of the heart and circulation.