Patents by Inventor Roman Gabriel

Roman Gabriel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID STATE FORMS OF N-[2-(2-{4-[2-(6,7-DIMETHOXY-3,4-DIHYDRO-2(1H)-ISOQUINOLINYL)ETHYL]PHENYL}-2H-TETRAZOL-5-YL)-4,5-DIMETHOXYPHENYL]-4-OXO-4H-CHROMENE-2-CARBOXAMIDE MESYLATE SALT
    Publication number: 20230278990
    Abstract: The present disclosure relates to solid state forms of Encequidar and Encequidar mesylate, processes for their preparation, and pharmaceutical compositions thereof.
    Type: Application
    Filed: July 9, 2021
    Publication date: September 7, 2023
    Inventors: Pavel Kolesa, Miroslav Vavrecka, Roman Gabriel, Martin Valík
  • SOLID STATE FORMS OF RELUGOLIX
    Publication number: 20220227784
    Abstract: The present disclosure provides solid state forms of Relugolix, crystalline forms of Relugolix, pharmaceutical compositions thereof, and pharmaceutical formulations thereof. Methods for producing these forms of Relugolix, pharmaceutical compositions, and pharmaceutical formulations are also provided.
    Type: Application
    Filed: April 6, 2022
    Publication date: July 21, 2022
    Inventors: Hana Kantor, Roman Gabriel, Pavel Kolesa, Alexandr Jegorov
  • Solid state forms of Relugolix
    Patent number: 11306104
    Abstract: The present disclosure provides solid state forms of Relugolix, crystalline forms of Relugolix, pharmaceutical compositions thereof, and pharmaceutical formulations thereof. Methods for producing these forms of Relugolix, pharmaceutical compositions, and pharmaceutical formulations are also provided.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: April 19, 2022
    Assignee: TEVA PHARMACEUTICALS INTERNATIONAL GMBH
    Inventors: Hana Kantor, Roman Gabriel, Pavel Kolesa, Alexandr Jegorov
  • NEW CRYSTALLINE POLYMORPHS OF RIGOSERTIB SODIUM
    Publication number: 20210395193
    Abstract: The present disclosure encompasses crystalline polymorphs of Rigosertib Sodium, processes for preparation thereof, and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 24, 2019
    Publication date: December 23, 2021
    Inventors: Pavel Kolesa, Roman Gabriel, Alexandr Jegorov
  • SOLID STATE FORMS OF IXAZOMIB CITRATE
    Publication number: 20210300950
    Abstract: The present disclosure encompasses solid state forms of Ixazomib Citrate and pharmaceutical compositions thereof. Also disclosed are processes for preparation of Ixazomib Citrate.
    Type: Application
    Filed: June 14, 2021
    Publication date: September 30, 2021
    Inventors: Martin VALIK, Roman GABRIEL, Pavel VRASPIR, David LUKAS
  • Solid state forms of ixazomib citrate
    Patent number: 11053261
    Abstract: The present disclosure encompasses solid state forms of Ixazomib Citrate and pharmaceutical compositions thereof. Also disclosed are processes for preparation of Ixazomib Citrate.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: July 6, 2021
    Assignee: TEVA PHARMACEUTICALS INTERNATIONAL GMBH
    Inventors: Martin Valik, Roman Gabriel, Pavel Vraspir, David Lukas
  • SOLID STATE FORMS OF RELUGOLIX
    Publication number: 20210017188
    Abstract: The present disclosure provides solid state forms of Relugolix, crystalline forms of Relugolix, pharmaceutical compositions thereof, and pharmaceutical formulations thereof. Methods for producing these forms of Relugolix, pharmaceutical compositions, and pharmaceutical formulations are also provided.
    Type: Application
    Filed: March 14, 2019
    Publication date: January 21, 2021
    Inventors: Hana Kantor, Roman Gabriel, Pavel Kolesa, Alexandr Jegorov
  • SOLID STATE FORMS OF IXAZOMIB CITRATE
    Publication number: 20200190119
    Abstract: The present disclosure encompasses solid state forms of Ixazomib Citrate and pharmaceutical compositions thereof. Also disclosed are processes for preparation of Ixazomib Citrate.
    Type: Application
    Filed: February 26, 2020
    Publication date: June 18, 2020
    Inventors: Martin VALIK, Roman GABRIEL, Pavel VRASPIR, David LUKAS
  • Solid state forms of ixazomib citrate
    Patent number: 10604537
    Abstract: The present disclosure encompasses solid state forms of Ixazomib Citrate and pharmaceutical compositions thereof. Also disclosed are processes for preparation of Ixazomib Citrate.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: March 31, 2020
    Assignee: TEVA PHARMACEUTICALS INTERNATIONAL GMBH
    Inventors: Martin Valik, Roman Gabriel, Pavel Vraspir, David Lukas
  • SOLID STATE FORMS OF IXAZOMIB CITRATE
    Publication number: 20190330243
    Abstract: The present disclosure encompasses solid state forms of Ixazomib Citrate and pharmaceutical compositions thereof. Also disclosed are processes for preparation of Ixazomib Citrate.
    Type: Application
    Filed: June 8, 2017
    Publication date: October 31, 2019
    Inventors: Martin VALIK, Roman GABRIEL, Pavel VRASPIR, David LUKAS
  • Connection element for a support frame system
    Patent number: 9568034
    Abstract: A connection element for a support frame system includes at least two part elements configured substantially in U shape and joinable together in mirror-inverted form. The elements can be plugged into one another in mirror-inverted form, with the first part element connectable to at least one fastening element and with the second part element connectable to at least one positioning element and/or having at least one positioning element.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: February 14, 2017
    Assignee: Liebherr-Transportation Systems GmbH & Co. KG
    Inventor: Roman Gabriel
  • Solid state forms of cabazitaxel and processes for preparation thereof
    Patent number: 9394266
    Abstract: The invention relates to solid state forms of Cabazitaxel and processes for preparing the solid state forms. The invention further relates to pharmaceutical compositions and formulations comprising one or more of the solid state forms.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: July 19, 2016
    Assignee: Ivax International GmBh
    Inventors: Pavel Vraspir, Alexandr Jegorov, Roman Gabriel, Ales Gavenda
  • Solid State Forms Of Cabazitaxel And Processes For Preparation Thereof
    Publication number: 20150073159
    Abstract: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 12, 2015
    Inventors: Ondrej SIMO, Pavel VRASPIR, Tomas HOLAS, Alexandr JEGOROV, Roman GABRIEL
  • SOLID STATE FORMS OF CABAZITAXEL AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20150038564
    Abstract: The invention relates to solid state forms of Cabazitaxel and processes for preparing the solid state forms. The invention further relates to pharmaceutical compositions and formulations comprising one or more of the solid state forms.
    Type: Application
    Filed: March 7, 2013
    Publication date: February 5, 2015
    Inventors: Pavel Vraspir, Alexandr Jegorov, Roman Gabriel, Ales Gavenda
  • Solid state forms of cabazitaxel and processes for preparation thereof
    Patent number: 8921411
    Abstract: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: December 30, 2014
    Assignee: Plus Chemicals SA
    Inventors: Ondrej Simo, Pavel Vraspir, Tomas Holas, Alexandr Jegorov, Roman Gabriel
  • Connection Element for a Support Frame System
    Publication number: 20140241796
    Abstract: A connection element for a support frame system includes at least two part elements configured substantially in U shape and joinable together in mirror-inverted form. The elements can be plugged into one another in mirror-inverted form, with the first part element connectable to at least one fastening element and with the second part element connectable to at least one positioning element and/or having at least one positioning element.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 28, 2014
    Inventor: Roman Gabriel
  • SOLID STATE FORMS OF CABAZITAXEL AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20140011865
    Abstract: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 9, 2014
    Applicant: PLUS CHEMICALS SA
    Inventors: Ondrej SIMO, Pavel Vraspir, Tomas Holas, Alexandr Jegorov, Roman Gabriel
  • Polymorphs of fluticasone furoate and process for preparation thereof
    Patent number: 8148353
    Abstract: Provided are polymorphs of fluticasone furoate and processes for preparation thereof.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: April 3, 2012
    Assignee: Plus Chemicals SA
    Inventors: Peter Lindsay MacDonald, Pierluigi Rossetto, Adrienne Kovacsne-Mezei, Roman Gabriel, Alexandr Jegorov, Jiri Faustmann
  • Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof
    Patent number: 8067423
    Abstract: The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: November 29, 2011
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ondrej {hacek over (S)}imo, Ji{hacek over (r)}í Filip{hacek over (c)}ík, Alexandr Martaus, Alexandr Jegorov, Ale{hacek over (s)} Gavenda, Judith Aronhime, Pavel Vraspir, Tamás Koltai, Ji{hacek over (r)}í Faustmann, Roman Gabriel
  • Methods for the preparation of salts of 2-[2-(4-dibenzo[B,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxyl]ethanol (quetiapine) and for the purification thereof
    Patent number: 8034805
    Abstract: A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1 -piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mixture of an aromatic hydrocarbon and a ketone or ester, or that of an aromatic hydrocarbon, water and a ketone or ester. The salts of quetiapine are purified by partial crystallization, wherein only a part of the salt of quetiapine is dissolved in a C1 to C6 alcohol used.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: October 11, 2011
    Assignee: Farmak, A.S.
    Inventors: Pavel Hradil, Lubomir Kvapil, Roman Gabriel, Martin Grepl, Jan Novotny, Petr Slezar, Radek Melnicky