Abstract: The invention relates to a nozzle device (100) for producing a three-dimensional component made of a material, in particular a shotcrete component made of concrete, a material application system (1), a manufacturing system (200) and a method for producing a three-dimensional component made of a material, in particular a shotcrete component made of concrete. In particular, the invention relates to a nozzle device (100) for producing a three-dimensional component made of a material, in particular a shotcrete component made of concrete, comprising a nozzle unit (101) with a material guide (102), which has a material inlet (104) for introducing a material, in particular a concrete, and a nozzle element (106) fluidically coupled to the material inlet (104) for applying the material, in particular the concrete, which is preferably arranged replaceably on the nozzle unit (101).

Abstract: The invention relates to a manufacturing system (1) for additively producing concrete components, in particular for carrying out a spraying process for additively producing concrete components, a method for additively producing a concrete component, in particular using a shotcrete process, and a method for setting up a manufacturing system (1).

Abstract: The invention relates to a method for manufacturing a reinforced concrete component (1, 1?), in particular a generatively produced reinforced concrete component (1, 1?), a reinforced concrete component and a manufacturing system for manufacturing a reinforced concrete component.

Abstract: The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable pharmaceutical compositions and the use of the compound for the treatment of basal-cell carcinomas are disclosed.

Abstract: Disclosed herein is a new route of synthesis and a new stable amorphous form of ibrutinib. Also disclosed are pharmaceutical compositions, oral dosage forms and the use of the amorphous ibrutinib in the treatment of mantle cell lymphoma or chronic lymphocytic leukemia.

Abstract: The present invention relates to a new route of synthesis for obtaining Opicapone ((4Z)-4-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-2H-1,2,4-oxadia-zol-5-ylidene]-2-hydroxy-6-nitrocyclohexa-2,5-dien-1-one), new intermediates in the reaction path and the new substance 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidoyl chloride.

Abstract: The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable pharmaceutical compositions and the use of the compound for the treatment of basal-cell carcinomas are disclosed.

Abstract: In a cutting device for a mining machine, in particular a shearer, including a tool carrier, in particular a shearer drum, that is rotatably mounted about a rotational axis and at least one cutting tool (1) that is fixed to the tool carrier, the cutting tool (1) comprises a tool base body (3) and a cutting insert (1) made of a diamond composite material or a harder material and fixed in a receiving bore (6) of the tool base body. The cutting tool is oriented on the tool carrier at an incident cutting angle (?) of 45-58°, preferably 47-54°, preferably 49°. The tip (2) of the cutting insert (1) is substantially conically designed, with the nose angle being 60-75°.