Patents by Inventor Roman Hovorka
Roman Hovorka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11246986Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: GrantFiled: January 18, 2019Date of Patent: February 15, 2022Assignee: Abbott Diabetes Care Inc.Inventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Publication number: 20210361867Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: ApplicationFiled: August 10, 2021Publication date: November 25, 2021Applicants: Abbott Diabetes Care Inc., Cambridge Enterprise LimitedInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Publication number: 20190151540Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: ApplicationFiled: January 18, 2019Publication date: May 23, 2019Applicants: Abbott Diabetes Care Inc., Cambridge Enterprise LimitedInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Publication number: 20170135643Abstract: A system and method for reducing the number of hypoglycemic alarms presented to a user is presented. The system and methods include use of model based state estimation and variable-delayed threshold values to balance the risk of not presenting an alarm caused by an actual hypoglycemic state with the presentation of alarms caused by artifacts in the signals produced by a continuous glucose monitor.Type: ApplicationFiled: January 24, 2017Publication date: May 18, 2017Inventors: Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka, Malgorzata E. Wilinska, David Dunger
-
Publication number: 20170080152Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: ApplicationFiled: June 27, 2016Publication date: March 23, 2017Inventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Patent number: 9579456Abstract: A system and method for reducing the number of hypoglycemic alarms presented to a user is presented. The system and methods include use of model based state estimation and variable-delayed threshold values to balance the risk of not presenting an alarm caused by an actual hypoglycemic state with the presentation of alarms caused by artifacts in the signals produced by a continuous glucose monitor.Type: GrantFiled: May 21, 2010Date of Patent: February 28, 2017Assignees: ABBOTT DIABETES CARE INC., CAMBRIDGE ENTERPRISE LIMITEDInventors: Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka, Malgorzata Wilinska, David Dunger
-
Patent number: 9402953Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: GrantFiled: November 18, 2013Date of Patent: August 2, 2016Assignees: ABBOTT DIABETES CARE INC., CAMBRIDGE ENTERPRISE LIMITEDInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Publication number: 20150220702Abstract: Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied.Type: ApplicationFiled: February 5, 2015Publication date: August 6, 2015Applicant: Cambridge Enterprise LimitedInventor: Roman HOVORKA
-
Patent number: 9089305Abstract: Diabetes management apparatus comprising a sensor providing measurements of glucose level in a human or animal; an insulin pump for delivering a dose of insulin to said human or animal; and a processor. The processor is adapted to perform the following steps: receive said measurements of glucose level from said sensor; calculate a insulin dose to be delivered by said insulin pump based on said received measurement; assess the validity of the status of the apparatus; and send a command to said insulin pump to deliver said calculated insulin dose, dependent on said assessing step confirming that the status is valid.Type: GrantFiled: December 8, 2009Date of Patent: July 28, 2015Assignee: CAMBRIDGE ENTERPRISE LIMITEDInventor: Roman Hovorka
-
Patent number: 8977504Abstract: Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied.Type: GrantFiled: October 10, 2008Date of Patent: March 10, 2015Assignee: Cambridge Enterprise LimitedInventor: Roman Hovorka
-
Publication number: 20140081236Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: ApplicationFiled: November 18, 2013Publication date: March 20, 2014Applicants: ABBOTT DIABETES CARE INC., Cambridge Enterprise Limited, CAMBRIDGE UNIVERSITY LIMITEDInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Patent number: 8585637Abstract: A closed-loop method for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: GrantFiled: September 22, 2011Date of Patent: November 19, 2013Assignees: Abbott Diabetes Care Inc., Cambridge Enterprise LimitedInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Publication number: 20120010600Abstract: A closed-loop method for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: ApplicationFiled: September 22, 2011Publication date: January 12, 2012Applicants: CAMBRIDGE ENTERPRISE LIMITED, ABBOTT DIABETES CARE INC.Inventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Patent number: 8062249Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: GrantFiled: March 31, 2010Date of Patent: November 22, 2011Assignees: Abbott Diabetes Care Inc., Cambridge Enterprise LimitedInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka
-
Publication number: 20110257627Abstract: Diabetes management apparatus comprising a sensor providing measurements of glucose level in a human or animal; an insulin pump for delivering a dose of insulin to said human or animal; and a processor. The processor is adapted to perform the following steps: receive said measurements of glucose level from said sensor; calculate a insulin dose to be delivered by said insulin pump based on said received measurement; assess the validity of the status of the apparatus; and send a command to said insulin pump to deliver said calculated insulin dose, dependent on said assessing step confirming that the status is valid.Type: ApplicationFiled: December 8, 2009Publication date: October 20, 2011Inventor: Roman Hovorka
-
Publication number: 20110040487Abstract: Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied.Type: ApplicationFiled: October 10, 2008Publication date: February 17, 2011Inventor: Roman Hovorka
-
Publication number: 20100317952Abstract: A system and method for reducing the number of hypoglycemic alarms presented to a user is presented. The system and methods include use of model based state estimation and variable-delayed threshold values to balance the risk of not presenting an alarm caused by an actual hypoglycemic state with the presentation of alarms caused by artifacts in the signals produced by a continuous glucose monitor.Type: ApplicationFiled: May 21, 2010Publication date: December 16, 2010Applicant: ABBOTT DIABETES CARE INC.Inventors: Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka, Malgorzata Wilinska, David Dunger
-
Publication number: 20100280441Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).Type: ApplicationFiled: March 31, 2010Publication date: November 4, 2010Applicants: ABBOTT DIABETES CARE INC., CAMBRIDGE ENTERPRISE LIMITEDInventors: Malgorzata E. Wilinska, Erwin S. Budiman, Gary A. Hayter, Marc B. Taub, Roman Hovorka