Abstract: A robotic medical system for performing a vascular procedure includes a procedure rail having a drive surface oriented along a generally vertical plane, a rail adjustment system configured to couple to a patient support table and having one or more movable arm segments, a fluidics system, and a plurality of catheter hubs operatively coupled to the procedure rail and configured to be axially translated along the drive surface along a longitudinal axis of the procedure rail. At least one of the plurality of catheter hubs is in fluid communication with the fluidics system, the at least one of the plurality of catheter hubs having a hemostasis valve and a catheter in communication with the hemostasis valve.

Abstract: The present invention provides new bicyclic tetrahydroazepine derivatives having the general formula (I), wherein X, Y, R1, R2, R3, R4, R5, R6, R6a are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using them in the treatment of cancer.

Abstract: The invention provides bifunctional compounds of formula (I) or a pharmaceutically acceptable salt thereof. Formula (I). The compounds cause the degradation of SMARCA2 via the targeted ubiquination of SMARCA2 protein and subsequent proteasomal degradation and are thus useful for the treatment of cancer. The targeting ligand is of formula (TL).

Abstract: The invention provides a bifunctional compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein said Targeting Ligand, Linker and Degron are as described herein.