Patents by Inventor Roman Lopez

Roman Lopez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR DETERMINING SPATIAL COORDINATES OF A SOURCE CAUSING A DISPERSION EFFECT
    Publication number: 20250013713
    Abstract: A method for determining spatial coordinates of a source causing a dispersion effect in a domain, the dispersion effect being approximated by a system of partial differential equations, the method including computer-implemented steps, of obtaining measurements each quantifying at a point in space in the domain and at a given time a state variable modeled by the system of partial differential equations at the point and at the time, and of iteratively minimizing differences between the measurements and the computations of the system of equations to locate a position of the source. The system of equations is expressed in terms of finite differences generated by radial basis functions, the system of equations being solved in a least-squares context, using a least-squares solver, the system of equations having been subject to adjoint quadratic solution with radial basis functions chosen from polyharmonic-spline functions, inverse-multiquadric functions, or Gaussian functions.
    Type: Application
    Filed: July 2, 2024
    Publication date: January 9, 2025
    Inventors: Roman LOPEZ-FERBER, Sylvain LEIRENS, Didier GEORGES
  • Compounds Which Have a Protective Activity with Respect to the Action of Toxins and of Viruses with an Intracellular Mode of Action
    Publication number: 20170233386
    Abstract: The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.
    Type: Application
    Filed: April 24, 2017
    Publication date: August 17, 2017
    Applicant: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Roman Lopez, Séverine Hebbe, Daniel Gillet, Julien Barbier
  • Selective inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications
    Patent number: 9328093
    Abstract: The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 3, 2016
    Assignee: HYBRIGENICS SA
    Inventors: Roman Lopez, Frederic Colland
  • COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION
    Publication number: 20160083355
    Abstract: The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.
    Type: Application
    Filed: July 27, 2015
    Publication date: March 24, 2016
    Inventors: Roman Lopez, Severine Hebbe, Daniel Gillet, Julien Barbier
  • NOVEL SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20150072973
    Abstract: The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
    Type: Application
    Filed: September 17, 2014
    Publication date: March 12, 2015
    Inventors: Roman Lopez, Frederic Colland
  • Compounds having a monogalactosyldiacylglycerol synthase inhibitory activity as herbicide or algaecide, herbicide and algaecide compositions
    Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • NOVEL SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20130023521
    Abstract: The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
    Type: Application
    Filed: January 17, 2011
    Publication date: January 24, 2013
    Applicant: HYBRIGENICS SA
    Inventors: Roman Lopez, Frederic Colland
  • Novel compounds which have a protective activity with respect to the action of toxins and of viruses with an intracellular mode of action
    Publication number: 20120283249
    Abstract: The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.
    Type: Application
    Filed: June 17, 2009
    Publication date: November 8, 2012
    Inventors: Roman Lopez, Séverine Hebbe, Daniel Gillet, Julien Barbier
  • Novel Selective Inhibitors of Ubiquitin Specific Protease 7, the Pharmaceutical Compositions Thereof and Their Therapeutic Applications
    Publication number: 20110177105
    Abstract: The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
    Type: Application
    Filed: August 13, 2010
    Publication date: July 21, 2011
    Inventors: Roman Lopez, Frédéric Colland
  • Compounds with Antiparasitic Activity, Applications thereof to the Treatment of Infectious Diseases Caused by Apicomplexans
    Publication number: 20100292214
    Abstract: The Invention relates to compounds having an antiparasitic activity, and to their use as a drug, in particular as a drug for the prevention and/or treatment of parasitic diseases caused by apicomplexans. The invention also relates to pharmaceutical compositions containing those compounds.
    Type: Application
    Filed: June 2, 2008
    Publication date: November 18, 2010
    Applicants: commissariat a l'Energie Atomique, Centre National De La Recherche Scientifique
    Inventors: Michael Deligny, Nadia Saidani, Anne-Laure Bonneau, Cyrille Botte, Helene Hardre, Bernard Rousseau, Henri Vial, Corinne Mercier, Roman Lopez, Eric Marechal
  • Use of Compounds Having a Mongalactosydiacylglycerol Syhnthase Inhibitory Activity as Herbicide or Algaecide, Herbicide and Algaecide Compositions
    Publication number: 20100273653
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Application
    Filed: June 2, 2008
    Publication date: October 28, 2010
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Helene Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Novel Dihydropyrimidine Derivatives And Their Use As Anti-Cancer Agents
    Publication number: 20080145453
    Abstract: The invention concerns molecules of formula (I), drugs containing same and their use as anti-cancer agents.
    Type: Application
    Filed: March 14, 2006
    Publication date: June 19, 2008
    Inventors: Roman Lopez, Bernard Rousseau, Frank Kozielsky, Dimitrios Skoufias, Salvatore De Bonis