Abstract: The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain consisting of one antibody variable domain capable of binding to an epitope of the human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an epitope of a human and a non-chimpanzee primate tumor target antigen. The invention further relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3? (epsilon) chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain consisting of one antibody variable domain capable of binding to an epitope of a human and a non-chimpanzee primate tumor target antigen.

Abstract: The present invention relates to uses of bispecific antibodies exhibiting cross-species specificity for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of the same in non-human species and humans. The present invention moreover relates to methods for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of said bispecific antibodies exhibiting cross-species specificity. The present invention also relates to methods of measuring the biological activity and/or efficacy of such bispecific antibodies exhibiting cross-species specificity. In addition, the present invention relates to pharmaceutical compositions comprising bispecific single chain antibodies exhibiting cross-species specificity and to methods for the preparation of pharmaceutical compositions comprising said bispecific single chain antibodies exhibiting cross-species specificity for the treatment of diseases.

Abstract: A universal clamp apparatus for orthopedic exterior fixators is disclosed. Preferably, the universal clamp apparatus has two pin/rod clamps, each having seating grooves for attaching to a frame rod associated with a frame of the fixator and/or a bone pin for implantation in a bone fragment. A clamp screw extends through and connects the first and second pin/rod clamps. An ergonomically designed knob having at least one collapsible or non-collapsible turn lever acts as a torque amplifier when rotated by hand without tools to tighten and untighten the pin/rod clamps to the frame rod and/or bone pin by movement along the clamp screw. The pin/rod clamps have planar sides that are contiguous and have radial ratchet grooves that are in mating engagement and provide a ratcheting mechanism so that the rotation of the pin/rod clamps relative to each other occurs in incremental rotational steps.

Abstract: A universal clamp apparatus for orthopedic external fixators is disclosed. Preferably, the universal clamp apparatus has two pin/rod clamps, each having seating grooves for attaching to a frame rod associated with a frame of the fixator and/or a bone pin for implantation in a bone fragment. A clamp screw extends through and connects the first and second pin/rod clamps. An ergonomically designed knob having at least one collapsible or non-collapsible turn lever acts as a torque amplifier when rotated by hand without tools to tighten and untighten the pin/rod clamps to the frame rod and/or bone pin by movement along the clamp screw. The pin/rod clamps have planar sides that are contiguous and have radial ratchet grooves that are in mating engagement and provide a ratcheting mechanism so that the rotation of the pin/rod clamps relative to each other occurs in incremental rotational steps.

Abstract: Embodiments of a universal clamp apparatus for an orthopedic exterior fixator are disclosed. The universal clamp apparatus can be operated without the need for tools, with extraordinary tightening precision, and with low risk of losing stability. The universal clamp apparatus has at least one pin/rod clamp, but preferably two pin/rod clamps. Each clamp has seating grooves for snapping in and attaching to at least one of the following: a frame rod associated with a frame of the fixator and/or a bone pin for implantation in a bone fragment. A screw mechanism, such as a clamp screw, extends through and connects the first and second pin/rod clamps. An ergonomically designed knob having at least one collapsible or non-collapsible turn lever acts as a torque amplifier when rotated to tighten and untighten the pin/rod clamps to the frame rod and/or bone pin by movement along the clamp screw.