Patents by Inventor Roman Sobotik

Roman Sobotik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the isolation of paclitaxel
    Publication number: 20090216031
    Abstract: Paclitaxel is isolated by a process including normal phase chromatography using a polyamide stationary phase and a mixture containing a dialkyl ketone and a less polar solvent as a mobile phase. Suitable dialkyl ketones include acetone or methyl isobutyl ketone. Suitable less polar co-solvents include a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon, a (C1-C4) dialkyl ether or their mixtures.
    Type: Application
    Filed: July 1, 2005
    Publication date: August 27, 2009
    Applicant: IVAX Pharmaceuticals s.r.o.
    Inventors: Martin Buchta, Ladislav Cvak, Roman Sobotik, Pavel Stverka
  • Polymorphs of cabergoline
    Patent number: 7531551
    Abstract: Provided are new crystalline Forms VIII, IX, XI, XII, XIV, XV, XVI, XVII, and XVIII of cabergoline. Also provided are novel processes for preparation of cabergoline Form I, Form II, Form VII, and amorphous cabergoline.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: May 12, 2009
    Assignee: IVAX Pharmaceuticals s.r.o.
    Inventors: Roman Bedná{hacek over (r)}, Ladislav Cvak, Alexandr Jegorov, Roman Sobotik
  • Process for the Separation of Paclitaxel and Cephalomannin
    Publication number: 20080214847
    Abstract: Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon, a (C1-C4) dialkyl ether or their mixtures.
    Type: Application
    Filed: July 1, 2005
    Publication date: September 4, 2008
    Applicant: Ivax Pharmaceuticals s.r.o.
    Inventors: Martin Buchta, Ladislav Cvak, Roman Sobotik, Pavel Stverka
  • Polymorphs of cabergoline
    Publication number: 20050085499
    Abstract: Provided are new crystalline Forms VIII, IX, XI, XII, XIV, XV, XVI, XVII, and XVIII of cabergoline. Also provided are novel processes for preparation of cabergoline Form I, Form II, Form VII, and amorphous cabergoline.
    Type: Application
    Filed: May 7, 2004
    Publication date: April 21, 2005
    Inventors: Roman Bednar, Ladislav Cvak, Alexandr Jegorov, Roman Sobotik
  • Process for the preparation of 3, 14.beta.-dihydroxy-17-normorphinan
    Patent number: 5504208
    Abstract: Process for the preparation of 3,14.beta.-dihydroxy-17-normorphinan ##STR1## A suitable economic process for the preparation of 3,14.beta.-dihydroxy-17-normorphinan of a general formula (I) is being solved, which is a key intermediate of a semisynthetic synthesis of an effective analgesic of Butorphanol from thebaine.Synthesis includes a two step N-demethylation, and concerted dephenoxylation of 4-phenoxy-14.beta.-hydroxy-3-methoxymorphinan in the first step by means of a chloroformate, then, in the second step, by means of sodium action in a liquid ammonia, and by means of the following O-demethylation under action of a complex of aluminium chloride - dialkylsulfide.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 2, 1996
    Assignee: Galena a.s.
    Inventors: Roman Sobotik, Petr Bulej, Tomas Kolasin, Alexandr Jegorov, Petr Sedmera, Ales Husek, Anna Jurcakova