Patents by Inventor Roman V. Shchepin

Roman V. Shchepin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11156684
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: October 26, 2021
    Assignees: Duke University, Vanderbilt University, Board of Trustees of Southern Illinois University
    Inventors: Warren S. Warren, Thomas Theis, Eduard Y. Chekmenev, Milton L. Truong, Aaron M. Coffey, Boyd Goodson, Fan Shi, Roman V. Shchepin
  • Publication number: 20210252493
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 19, 2021
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • Patent number: 11016152
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 25, 2021
    Assignees: Vanderbilt University, Duke University, The Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Publication number: 20200132788
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Application
    Filed: May 12, 2018
    Publication date: April 30, 2020
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Patent number: 10338052
    Abstract: Methods of detecting a sulfur-containing compound in a sample are described, for example using NMR-SABRE hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. A spin order can be transferred from the parahydrogen to the sulfur-containing compound thereby hyperpolarizing the sulfur-containing compound during a temporary association of the parahydrogen, the sulfur-containing compound, and the catalyst. The methods can further comprise, for example, performing an NMR measurement on the mixture comprising the hyperpolarized sulfur-containing compound to detect the hyperpolarized sulfur-containing compound (e.g., from the hyperpolarized NMR signals. In some examples, the methods described herein can be used for detecting a sulfur-containing contaminant in a fuel.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: July 2, 2019
    Assignee: Vanderbilt University
    Inventors: Eduard Y. Chekmenev, Roman V. Shchepin
  • Patent number: 9790245
    Abstract: Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: October 17, 2017
    Assignees: Vanderbilt University, Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Boyd M. Goodson, Roman V. Shchepin, Milton L. Truong, Ping He, Quinn A. Best, Fan Shi, Kirsten A. Groome, Aaron M. Coffey
  • Publication number: 20170153218
    Abstract: Methods of detecting a sulfur-containing compound in a sample are described, for example using NMR-SABRE hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. A spin order can be transferred from the parahydrogen to the sulfur-containing compound thereby hyperpolarizing the sulfur-containing compound during a temporary association of the parahydrogen, the sulfur-containing compound, and the catalyst. The methods can further comprise, for example, performing an NMR measurement on the mixture comprising the hyperpolarized sulfur-containing compound to detect the hyperpolarized sulfur-containing compound (e.g., from the hyperpolarized NMR signals. In some examples, the methods described herein can be used for detecting a sulfur-containing contaminant in a fuel.
    Type: Application
    Filed: November 29, 2016
    Publication date: June 1, 2017
    Inventors: Eduard Y. Chekmenev, Roman V. Shchepin
  • Publication number: 20160169998
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
    Type: Application
    Filed: October 28, 2015
    Publication date: June 16, 2016
    Inventors: Warren S. Warren, Thomas Theis, Eduard Y. Chekmenev, Milton Y. Truong, Aaron M. Coffey, Boyd Goodson, Fan Shi, Roman V. Shchepin
  • Publication number: 20160045907
    Abstract: Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Application
    Filed: July 16, 2015
    Publication date: February 18, 2016
    Inventors: Eduard Y. Chekmenev, Boyd M. Goodson, Roman V. Shchepin, Milton L. Truong, Ping He, Quinn A. Best, Fan Shi, Kirsten A. Groome, Aaron M. Coffey
  • Publication number: 20120225020
    Abstract: This disclosure provides choline analogs comprising the following structure: where each R1 independently is H or isotopically enriched D, R2 is a protecting group, and N is 14N or isotopically enriched 15N. This disclosure also provides methods of making choline analogs, which include performing a protection step on a betaine aldehyde to form a choline analog, and methods of using choline analogs to form hyperpolarized compounds.
    Type: Application
    Filed: February 24, 2012
    Publication date: September 6, 2012
    Inventors: Eduard Y. Chekmenev, Roman V. Shchepin