Patents by Inventor Romano Derungs

Romano Derungs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxetanones
    Patent number: 5466708
    Abstract: Novel compounds of the formula ##STR1## wherein Q, R.sup.1 and R.sup.2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of formula I which starts from the corresponding .beta.-hydroxycarboxylic acids.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: November 14, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Romano Derungs, Hans P. Marki, Henri Stalder, Andre Szente
  • Oxetanone compounds containing proline and pharmaceutical compositions thereof
    Patent number: 5376674
    Abstract: Novel compounds of the formula ##STR1## wherein Q, R.sup.1 and R.sup.2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of formula I which starts from the corresponding .beta.-hydroxycarboxylic acids.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: December 27, 1994
    Assignee: Hoffman-La Roche Inc.
    Inventors: Romano Derungs, Hans P. Marki, Henri Stalder, Andre Szente
  • Oxetanone compounds and pharmaceutical compositions containing them
    Patent number: 5260310
    Abstract: Novel compounds of the formula ##STR1## wherein Q, R.sup.1 and R.sup.2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of formula I which starts from the corresponding .beta.-hydroxycarboxylic acids.
    Type: Grant
    Filed: August 12, 1992
    Date of Patent: November 9, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Romano Derungs, Hans P. Marki, Henri Stalder, Andre Szente
  • Antithrombotic 4,5 di-t-butyl-imidazole derivatives
    Patent number: 4582844
    Abstract: Imidazole derivatives of the formula ##STR1## wherein X is hydrogen or C.sub.1-4 -n-alkyl and Y is thienyl, optionally substituted by methyl or fluorine, or a group of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen, methyl, fluorine, hydroxy or methoxy, or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy, or one of R.sup.1, R.sup.2 and R.sup.3 is mono- or di-(C.sub.1-4 -n-alkyl)-amino and the other two are hydrogen, and physiologically compatible or pharmaceutically acceptable acid addition salts thereof, are described. These compounds of formula I inhibit the aggregation of the blood platelets.
    Type: Grant
    Filed: September 10, 1985
    Date of Patent: April 15, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Romano Derungs
  • Blood-platelet aggregation inhibiting 4,5,7,8-tetrahydro-4,4,8,8-tetramethyl-2-thienyl-1H-thiepino[4,5-d]imida zole derivatives
    Patent number: 4493841
    Abstract: Imidazole derivatives of the formula ##STR1## wherein X is hydrogen or C.sub.1-4 -alkyl, Y is sulfur, sulfinyl or sulfonyl and Z is thienyl, optionally substituted by methyl or fluorine, or a group of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen, methyl, fluorine, hydroxy, methoxy, methylthio or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy or one of R.sup.1, R.sup.2 and R.sup.3 is mono- or di-(C.sub.1-4 -alkyl)-amino and the other two are hydrogen,and physiologically or pharmaceutically compatible or acceptable acid addition salts thereof, are described. The compounds of formula I inhibit the aggregation of the blood platelets and have antihyperglycemic activity.
    Type: Grant
    Filed: February 7, 1983
    Date of Patent: January 15, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Romano Derungs
  • Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and method of use
    Patent number: 4382945
    Abstract: Imidazole derivatives of the formula ##STR1## wherein X is hydrogen or C.sub.1-4 -alkyl, Y is sulfur, sulfinyl or sulfonyl and Z is thienyl, optionally substituted by methyl or fluorine, or a group of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen, methyl, fluorine, hydroxy, methoxy, methylthio or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy or one of R.sup.1, R.sup.2 and R.sup.3 is mono- or di-(C.sub.1-4 -alkyl)-amino and the other two are hydrogen,and physiologically or pharmaceutically compatible or acceptable acid addition salts thereof, are described. The compounds of formula I inhibit the aggregation of the blood platelets and have antihyperglycemic activity.
    Type: Grant
    Filed: April 16, 1981
    Date of Patent: May 10, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Romano Derungs