Patents by Inventor Romano Rivolta

Romano Rivolta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purifying 4-(nitrooxy)butyl(2S)-2-(6-methoxy-2-naphthyl) propanoate
    Patent number: 8329937
    Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from ?20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from ?40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: December 11, 2012
    Assignee: Nicox S.A.
    Inventors: Pietro Allegrini, Tiziano Scubla, Nicoletta Toniutti, Romano Rivolta, Thierry Delahaique
  • METHOD FOR PURIFYING 4-(NITROOXY)BUTYL(2S)-2-(6-METHOXY-2-NAPHTHYL) PROPANOATE
    Publication number: 20100256411
    Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from ?20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from ?40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 7, 2010
    Applicant: NICOX S.A.
    Inventors: Pietro Allegrini, Tiziano Scubla, Nicoletta Toniutti, Romano Rivolta, Thierry Delahaique
  • Process for preparing halogenoalkylnitrates
    Patent number: 7745496
    Abstract: A process for preparing a compound of formula (I) X-(CH2)n-ONO2??(I) wherein: X is a halogen atom selected from Cl, Br, I; n is an integer from 3 to 6; said process comprising the slow addition of a compound of formula (II) X-(CH2)n-OH??(II) wherein X and n are as defined above to a nitrating agent selected from the group consisting of concentrated nitric acid/concentrated sulfuric acid (sulfonitric mixture), nitric acid alone, NaNO2 in trifluoroacetic acid, nitronium salts such as NO2BF4 and an organic solvent selected from the group consisting of CH2Cl2, CHCl3, CCl4, perfluorohexane, perfluoroheptane. The invention refers also to solutions containing: a compound of general formula (I) and a solvent selected from the group consisting of CH2Cl2, CHCl3, CCl4, perfluorohexane, perfluoroheptane, characterized in that the compound of formula (I) is present in a concentration not higher than 20% by weight.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: June 29, 2010
    Assignee: Nicox S.A.
    Inventors: Romano Rivolta, Peter Finlander
  • Process for the preparation of nitrooxyderivatives of paracetamol
    Patent number: 7442826
    Abstract: The present invention relates to a new process for the preparation of a compound of the following formula (I):
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: October 28, 2008
    Assignee: Nicox S.A.
    Inventors: Romano Rivolta, Roberto Aureli
  • Process For Preparing Halogenoalkylnitrates
    Publication number: 20080004463
    Abstract: A process for preparing a compound of formula (I) X-(CH2)n-ONO2??(I) wherein: X is a halogen atom selected from Cl, Br, I; n is an integer from 3 to 6; said process comprising the slow addition of a compound of formula (II) X-(CH2)n-OH??(II) wherein X and n are as defined above to a nitrating agent selected from the group consisting of concentrated nitric acid/concentrated sulfuric acid (sulfonitric mixture), nitric acid alone, NaNO2 in trifluoroacetic acid, nitronium salts such as NO2BF4 and an organic solvent selected from the group consisting of CH2Cl2, CHCl3, CCl4, perfluorohexane, perfluoroheptane. The invention refers also to solutions containing: a compound of general formula (I) and a solvent selected from the group consisting of CH2Cl2, CHCl3, CCl4, perfluorohexane, perfluoroheptane, characterized in that the compound of formula (I) is present in a concentration not higher than 20% by weight.
    Type: Application
    Filed: November 9, 2005
    Publication date: January 3, 2008
    Inventors: Romano Rivolta, Peter Finlander
  • New process for the preparation of nitrooxyderivatives of paracetamol
    Publication number: 20070149801
    Abstract: The present invention relates to a new process for the preparation of a compound of the following formula (I):
    Type: Application
    Filed: November 4, 2004
    Publication date: June 28, 2007
    Inventors: Romano Rivolta, Roberto Aureli