Patents by Inventor Romeo Ciabatti
Romeo Ciabatti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120184497Abstract: The invention provides dosage forms and compositions for treatment of bacterial infections. The dosage form may include a sterile, stable, particle-free dalbavancin powder suitable for reconstitution with a pharmaceutically acceptable vehicle. The dosage form may include a dalbavancin factor B0 and at least one additional dalbavancin factor among A0, A1, B1, B2, C0, and C1. The dosage form may also include a stabilizing substance.Type: ApplicationFiled: March 23, 2012Publication date: July 19, 2012Inventors: Martin STOGNIEW, Luigi COLOMBO, Romeo CIABATTI
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Patent number: 8143212Abstract: The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A0, A1, B1, B2, C0, C1, isoB0, and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.Type: GrantFiled: June 2, 2009Date of Patent: March 27, 2012Assignee: Vicuron Pharmaceuticals Inc.Inventors: Martin Stogniew, Luigi Colombo, Romeo Ciabatti
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Patent number: 7169890Abstract: The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH— represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R—COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.Type: GrantFiled: February 26, 2003Date of Patent: January 30, 2007Assignee: Vicuron Pharmaceuticals Inc.Inventors: Romeo Ciabatti, Sonia Maffioli, Anna Checchia, Gabriella Romano, Gianpaolo Candiani, Gianbattista Panzone
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Publication number: 20060211603Abstract: Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.Type: ApplicationFiled: August 4, 2005Publication date: September 21, 2006Applicant: VICURON PHARMACEUTICALS INC.Inventors: Bore Raju, Romeo Ciabatti, Sonia Maffioli, Upinder Singh, Gabriella Romano, Elena Michelucci, Paolo Tiseni, Gianpaolo Candiani, Bum Kim, Hardwin O'Dowd
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Publication number: 20060074014Abstract: The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A0, A1, B1, B2, C0, C1, isoB0, and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.Type: ApplicationFiled: April 26, 2005Publication date: April 6, 2006Applicant: VICURON PHARMACEUTICALS INC.Inventors: Martin Stogniew, Luigi Colombo, Romeo Ciabatti
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Publication number: 20050106691Abstract: The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH— represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R—COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.Type: ApplicationFiled: February 26, 2003Publication date: May 19, 2005Applicant: VICURON PHARMACEUTICALS INC.Inventors: Romeo Ciabatti, Sonia Maffiolt, Anna Checchia, Gabriella Romano, Gianpaolo Candiani, Gianbattista Panzone
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Patent number: 6720305Abstract: The present invention relates to a pharmaceutical composition for intravenous administration that contains ramoplanin or a member of the ramoplanin family.Type: GrantFiled: January 30, 2001Date of Patent: April 13, 2004Assignee: Vicuron Pharmaceuticals Inc.Inventors: Francesco Parenti, Gianpaolo Candiani, Romeo Ciabatti, Marco Cavaleri
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Patent number: 6143739Abstract: The present invention refers to basic amides derivatives of GE 2270 and GE 2270-like antibiotics of general formula (1), wherein the group GE represents the antibiotic core molecule. The amide derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.Type: GrantFiled: July 31, 1997Date of Patent: November 7, 2000Assignee: Biosearch Italia S.p.A.Inventors: Sergio Lociuro, Pierfausto Seneci, Ermenegildo Restelli, Romeo Ciabatti
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Patent number: 6008225Abstract: Mono- or di-substituted derivatives of GE2270 factors C.sub.2a, D.sub.2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) or (c), R.sup.1 and R.sup.2 representing a variety of substituents, X.sup.1 is methyl, X.sup.2 is a --CH.sub.2 --W.sup.1 moiety and X.sup.3 is methylamino or amino, or X.sup.1 is a --CH.sub.2 --W.sup.1 moiety, X.sup.2 is methoxymethylene and X.sup.3 is methylamino, with the proviso that when X.sup.3 is amino, then W must be 2-(aminocarbonyl)-pyrrolidinyl; with the further proviso that when W is 2-(aminocarbonyl)-pyrrolidinyl, then W.sup.1 cannot be hydroxy; and the pharmaceutically acceptable salts thereof. The mono- or di-substituted derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.Type: GrantFiled: June 29, 1998Date of Patent: December 28, 1999Assignee: BioSearch Italia, S.p.A.Inventors: Sergio Lociuro, Paolo Tavecchia, Romeo Ciabatti, Ermenegildo Restelli
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Patent number: 5891869Abstract: The present invention refers to basic oxazoline-amide derivatives of GE 2270 and GE 2270-like antibiotics of general formula (I), wherein the group GE represents the antibiotic core molecule. The amide derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.Type: GrantFiled: July 31, 1997Date of Patent: April 6, 1999Assignee: Biosearch Italia, S.p.A.Inventors: Sergio Lociuro, Pierfausto Seneci, Romeo Ciabatti
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Patent number: 5869449Abstract: The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antiobiotics and a process for preparing them which includes submitted the corresponding lower alkyl ester precursor to a reduction reaction in the presence of an alkali metal borohydride. The compounds of the invention show an improved antibacterial activity against some clinical isolates of Staphylococci somewhat resistant to teicoplanin.The teicoplanin derivatives of the present invention are represented by the following formula: ##STR1## wherein: X represents hydroxymethyl;R represents hydrogen or --N?(C.sub.9 -C.sub.12)aliphatic acyl!-.beta.-D-2-deoxy-2-aminoglucopyranosyl;R.sub.1 represents hydrogen or N-acetyl-.beta.-D-2-deoxy-2-aminoglucopyranosyl;R.sub.2 represents hydrogen of alpha-D-mannopyranosyl;R.sub.3 represents hydrogen or a protecting group of the amino function; and the acid addition salts thereof; with the proviso that R.sub.1 represents hydrogen only when R and R.sub.Type: GrantFiled: June 10, 1997Date of Patent: February 9, 1999Assignee: Gruppo Lepetit S.P.A.Inventors: Adriano Malabarba, Romeo Ciabatti
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Patent number: 5786350Abstract: Rifamycin antibiotic derivatives of formulae (I) and (Ia) bearing at the position 36 a substituent selected from (C.sub.1 -C.sub.8)alkyl, halo, hydroxy, (C.sub.1 -C.sub.4)acyloxy, (C.sub.1-C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1-C.sub.4)alkylamino and substituted 4-oxo-3-pyridinyl carbonyloxy of formula (1) obtained by reacting rifamycin with suitably substituted malonic acid. The compounds of the invention are antimicrobial agents mainly active against gram positive bacteria and fastidious gram negative bacteria showing the considerable antimicrobial activity against the rifamypicin resistant microbial strains.Type: GrantFiled: January 31, 1997Date of Patent: July 28, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Emilio Occelli, Sergio Lociuro, Romeo Ciabatti, Maurizio Denaro
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Patent number: 5750509Abstract: The present invention is directed to novel antibiotic A 40926 derivatives characterized by having a carboxy, (C.sub.1 -C.sub.4) alkoxy-carbonyl, aminocarbonyl, (C.sub.1 -C.sub.4) alkylaminocarbonyl, di (C.sub.4 -C.sub.4)alkylaminocarbonyl or hydroxymethyl substituent on the N-acylaminoglucuronyl moiety and a hydroxy or a polyamine substituent in position 63 of the molecule. The compounds of the invention show high in vitro activity against glycopeptide resistant Enterococci and Staphylococci.Type: GrantFiled: April 30, 1996Date of Patent: May 12, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Adriano Malabarba, Romeo Ciabatti, Gianbattista Panzone, Alessandra Maria Marazzi
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Patent number: 5684127Abstract: Tetrapeptides of general formula (I) deriving from dalbaheptide antibiotics ##STR1## wherein: W and Z represent the relative portions of the aglycon of an antibiotic of the dalbaheptide group (aglucodalbaheptides);Y represents a carboxylic group or a functional derivative of said carboxylic group;R and R.sub.0 each independently represent amino or a protected amino group;R.sub.1 represents hydrogen or a protecting group of the carboxylic function;and its salts with acids and bases as well as its inner salts.A process for producing the tetrapeptides of formula (I) from the corresponding dalbaheptides and aglucodalbaheptides.Type: GrantFiled: June 6, 1995Date of Patent: November 4, 1997Assignee: Gruppo Lepetit SpAInventors: Adriano Malabarba, Romeo Ciabatti
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Patent number: 5674840Abstract: Synthetic aglucodalbaheptides of formula (I) wherein W and Z, each independently, represent the relative portions of the aglycon of an antibiotic of the dalbaheptide group. Y represents a carboxylic group or a functional derivative of said carboxylic group; R and R.sub.1, each independently, represent hydrogen or a protecting group of the amino function. R.sub.2 represents hydrogen; and their salts with acid and bases as well as their inner salts. A process for producing the aglucodabaheptides of formula (I) and their use as medicaments.Type: GrantFiled: December 26, 1995Date of Patent: October 7, 1997Assignee: Gruppo Lepetit SpAInventors: Adriano Malabarba, Romeo Ciabatti
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Patent number: 5648456Abstract: Pentapeptide antibiotics of the formula ##STR1## wherein W, Z, X.sub.1, X.sub.2 and T represent the relative portions of an antibiotic of the dalbaheptide group (glyccpeptide antibiotics), Y represents a carboxyacid group, a functional derivative of said carboxyacid group or a hydroxymethyl group. The invention includes the salts of the above represented pentapeptide antibiotics with acids or bases as well as their inner salts.The compounds are obtained by reductive cleavage of the peptidic bond between the second and the third aminoacid of the seven aminoacid chain of dalbaheptides (glycopeptide antibiotics). The inventions concerns also the reductive cleavage process which implies using an alkali metal borohydride as the reagent. The compounds show antibacterial activity against staphylococcal and streptococcal strains.Type: GrantFiled: May 31, 1995Date of Patent: July 15, 1997Assignee: Gruppo Lepetit S.p.A.Inventors: Adriano Malabarba, Romeo Ciabatti, Jurgen Kurt Kettenring
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Patent number: 5644025Abstract: Tetrapeptides of general formula (I) deriving from dalbaheptide antibiotics ##STR1## wherein: W and Z represent the relative portions of the aglycon of an antibiotic of the dalbaheptide group (aglucodalbaheptides);Y represents a carboxylic group or a functional derivative of said carboxylic group;R and R.sub.0 each independently represent amino or a protected amino group;R.sub.1 represents hydrogen or a protecting group of the carboxylic function;and its salts with acids and bases as well as its inner salts.A process for producing the tetrapeptides of formula (I) from the corresponding dalbaheptides and aglucodalbaheptides.Type: GrantFiled: February 17, 1995Date of Patent: July 1, 1997Assignee: Gruppo Lepetit SPAInventors: Adriano Malabarba, Romeo Ciabatti
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Patent number: 5606036Abstract: The present invention relates to novel ester derivatives of antibiotic A 40926 complex and its N-acylaminoglucuronyl aglycone. The compounds of the invention are prepared according to an esterification process involving reaction of an A 40926 substrate with an excess of the selected alkanol in the presence of concentrated mineral acid and are reactive as antibiotics.Type: GrantFiled: May 22, 1995Date of Patent: February 25, 1997Assignee: Gruppo Lepetit SpAInventors: Rolf H. Hermann, Romeo Ciabatti, Enrico Selva, Maurizio Denaro
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Patent number: 5602229Abstract: Pentapeptide antibiotics of the formula ##STR1## wherein W, Z, X.sub.1, X.sub.2 and T represent the relative portions of an antibiotic of the dalbaheptide group (glycopeptide antibiotics), Y represents a carboxyacid group, a functional derivative of a carboxyacid group or a hydroxymethyl group. The invention includes the salts of the above represented pentapeptide antibiotics with acids or bases as well as their inner salts.Type: GrantFiled: May 15, 1995Date of Patent: February 11, 1997Assignee: Gruppo Lepetit S.p.A.Inventors: Adriano Malabarba, Romeo Ciabatti, J urgen K. Kettenring
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Patent number: 5599791Abstract: The present invention is directed to novel amide derivatives of antibiotic GE 2270 compounds and a process for preparing them. Said amide derivatives are antimicrobial agents active against gram positive bacteria as well as gram negative bacteria.Type: GrantFiled: July 1, 1993Date of Patent: February 4, 1997Assignee: Gruppo Lepetit SPAInventors: Paolo Tavecchia, Sergio Lociuro, Romeo Ciabatti, Enrico Selva