Patents by Inventor Rommie E. Amaro

Rommie E. Amaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS THAT DEGRADE KINASES AND USES THEREOF
    Publication number: 20220233702
    Abstract: The disclosure is directed to compounds of the Formula (I) or (II): A—L1—B, A?—L1—B, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein A is an Aurora A ligand, A? is a CDK4/6 ligand; B is an E3 ligase ligand; and L1 is a linker, as well as pharmaceutical compositions comprising such compounds, and methods for treating cancer using such compounds.
    Type: Application
    Filed: June 3, 2020
    Publication date: July 28, 2022
    Inventors: Daniel A. Harki, Jian Tang, Ramkumar Moorthy, Rommie E. Amaro, Ozlem Demir
  • Small molecules to enhance P53 activity
    Patent number: 9737546
    Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.
    Type: Grant
    Filed: August 9, 2014
    Date of Patent: August 22, 2017
    Assignee: The Regents of the University of California
    Inventors: Rommie E. Amaro, Roberta Baronio, Ozlem Demir, Peter Kaiser, Richard H. Lathrop, Seyedey-Faezeh Salehi-Amin, Christopher D. Wassman
  • SMALL MOLECULES TO ENHANCE P53 ACTIVITY
    Publication number: 20160193214
    Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.
    Type: Application
    Filed: August 9, 2014
    Publication date: July 7, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rommie E. Amaro, Roberta Baronio, Ozten Demir, Peter Kaiser, Richard H. Lathrop, Seyedeh-Feezeh Salehi-Amin, Christopher D. Wassman