Patents by Inventor Romulus K. Brazzell

Romulus K. Brazzell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8349806
    Abstract: The present invention relates to a method for treating non-infectious, inflammatory chronic posterior blepharitis in a subject. The present invention also relates to a method for treating chronic posterior blepharitis in a subject for over two weeks. The method comprises identifying a subject in need thereof, and topically administering to the eye of the subject a pharmaceutical formulation consisting essentially of an effective amount azithromycin. The present invention further relates to a method for treating dry eye secondary to blepharitis in a subject. The method comprises the steps of: identifying a subject suffering from dry eye secondary to posterior blepharitis, and topically administering to the eye of the subject a pharmaceutical formulation comprising an effective amount of azithromycin. The present invention further relates to method for reducing contact lens intolerance of a subject due to blepharitis or dry eye secondary to blepharitis.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: January 8, 2013
    Assignee: Inspire Pharmaceuticals, Inc.
    Inventors: Kurt E. Brubaker, Romulus K. Brazzell, Reza M. Haque, John C. Ice, Jr., José L. Boyer, Joseph B. Boyd, Robert J. Dempsey
  • Patent number: 8158669
    Abstract: The present invention describes an improved photodynamic treatment to treat subfoveal choroidal neovascularization (CNV).
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: April 17, 2012
    Assignee: QLT, Inc.
    Inventor: Romulus K Brazzell
  • Publication number: 20110245190
    Abstract: The present invention relates to a method for treating dry eye disease, comprising the steps of identifying a subject suffering from dry eye disease, and administering to the subject an effective amount of azithromycin. The present invention also relates to a method for reducing contact lens intolerance in a subject, comprising the steps of: identifying a subject suffering from contact lens intolerance due to dry eye disease; and administering to the eyes of the subject an aqueous ophthalmic solution comprising azithromycin. The present invention also relates to a method for improving post surgery visual acuity outcome in a patient, comprising the steps of: identifying a patient in need of an ophthalmic surgical procedure, administering to the patient an effective amount of azithromycin prior to the ophthalmic surgical procedure, and performing the ophthalmic surgical procedures on the patient.
    Type: Application
    Filed: May 2, 2011
    Publication date: October 6, 2011
    Inventors: Romulus K. Brazzell, Reza M. Haque, Kurt E. Brubaker, Robert J. Dempsey, Joseph B. Boyd
  • Publication number: 20100022465
    Abstract: The present invention relates to a method for treating non-infectious, inflammatory chronic posterior blepharitis in a subject. The present invention also relates to a method for treating chronic posterior blepharitis in a subject for over two weeks. The method comprises identifying a subject in need thereof, and topically administering to the eye of the subject a pharmaceutical formulation consisting essentially of an effective amount azithromycin. The present invention further relates to a method for treating dry eye secondary to blepharitis in a subject. The method comprises the steps of: identifying a subject suffering from dry eye secondary to posterior blepharitis, and topically administering to the eye of the subject a pharmaceutical formulation comprising an effective amount of azithromycin. The present invention further relates to method for reducing contact lens intolerance of a subject due to blepharitis or dry eye secondary to blepharitis.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 28, 2010
    Inventors: Kurt E. Brubaker, Romulus K. Brazzell, Reza Haque, John C. Ice, JR., José L. Boyer, Joseph B. Boyd
  • Patent number: 5578638
    Abstract: This invention relates to a method of treating glaucoma or reducing intraocular pressure in a patient in need of such treatment which is based on the topical administration to the eye of a mammal or the systemic administration of a compound of the formula: ##STR1## wherein E', W', and the R groups are defined in the disclosure.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: November 26, 1996
    Assignee: American Cyanamid Company
    Inventors: Romulus K. Brazzell, Bernard Dubnick
  • Patent number: 5563171
    Abstract: Substituted 5-2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles having the structural formula: ##STR1## wherein R4, R5, R6, R7, and R8 are as hereinafter defined, are .beta.3-adrenergic agonists useful in the treatment of elevated intraocular pressure and glaucoma.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: October 8, 1996
    Assignee: American Cyanamid Company
    Inventors: Romulus K. Brazzell, Bernard Dubnick
  • Patent number: 5221537
    Abstract: Irrigating solutions with thiol or disulfide containing compounds in physiologically acceptable salt solutions are described. The irrigating solutions are useful during surgery, particularly ophthalmic, neural, cardiovascular or otic surgery, to stabilize the affected tissue. Methods for their preparation and use are described.
    Type: Grant
    Filed: July 13, 1992
    Date of Patent: June 22, 1993
    Inventors: Gerald Hecht, Michael E. Stern, Romulus K. Brazzell