Abstract: A microfluidic circuit cartridge for a complete blood count, including analyses of red blood cells. Various parameters of the red blood cells may be attained. The cartridge may have sphering mechanism which has a channel or loop with a configuration for reducing or eliminating cell settling. The channel or loop may incorporate a combination of straight and curve paths in the context of gravity. The channel may alternatively have a hydrophilic or hydrophobic inside surface. Again alternatively, the channel may have an electro-wettable inside surface. Or, the channel may be subject to an electric or magnetic field. There may also be a mechanism for reducing or eliminating clumping of a sample.

Abstract: A microfluidic circuit cartridge having 3-D hydrodynamic focusing. The cartridge may be fabricated with injection-molded or other molded layers providing a 3-D structure. A flow channel on the card may have a sample core flowing in a fluid of a flow channel for analysis. The sample core may be adjustable in position within the channel with one or more jets or channels of fluid being injected into the flow channel. The jets may also adjust the size of the sample core.

Abstract: A microfluidic device and method for improved diffusion between at least two parallel-flowing fluids. A structure for a microfluidic device includes a first inlet channel, a second inlet channel, and at least one outlet channel connected to the first and second inlet channels. A measure of the first inlet channel is smaller than a measure of the second inlet channel, directing a particular cross-sectional flow in the outlet channel that avoids a “butterfly effect” of adverse diffusion. In an outlet channel having at least two fluidic inlets, the chemical or physical properties of parallel-flowing fluids are controlled for diffusion, concentration, extraction or detection of a substance among the fluids.