Abstract: A dry powder Norovirus vaccine is provided, which comprises at least two Norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against Norovirus infections.

Abstract: A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.

Abstract: A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.

Abstract: A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.

Abstract: A sign assembly having a sign post, a first arcuate nesting component and a first sign panel. The sign post has a sign post perimeter, a sign post longitudinal axis and a sign post elongated slot extending substantially parallel to the longitudinal axis. The first arcuate nesting component is adapted to be secured to the sign post. The first sign panel is adapted to be retained by the first arcuate nesting component. The sign post and the first arcuate nesting component are configured and arranged such that when the first arcuate nesting component is secured to the sign post there is substantially no gap between the first sign panel and the sign post, and the first arcuate nesting component extends around a portion of the sign post perimeter.

Abstract: A sign assembly having a support surface including a first side frame portion, a second side frame portion and a back plate. The first side frame portion includes a longitudinal first recess having a bottom and a top, and the second side frame portion includes a longitudinal second recess having a bottom and a top. The sign assembly also includes a third side frame portion, a fourth side frame portion, a front panel and a locking pin. At least one of the third side frame portion and the fourth side frame portion includes at least one protuberance. The front panel includes a first side, a second side, a third side and a fourth side. The locking pin is adapted to be inserted into the longitudinal second recess.

Abstract: A sign assembly having a support surface including a first side frame portion, a second side frame portion and a back plate. The first and second side frame portions each include a longitudinal recess having a top and a bottom. The sign assembly also includes a third side frame portion, a fourth side frame portion, a front panel and a locking pin. The front panel includes a first side, a second side, a third side and a fourth side. The locking pin is adapted to be inserted into the second recess.