Abstract: An upright vacuum cleaner includes a nozzle assembly having an intake opening. A handle assembly is pivotally connected to the nozzle assembly. The vacuum cleaner also includes a suction generator and a dirt collection vessel. In addition, the vacuum cleaner includes a flexible, electrified hose such as a stretch hose.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and drive motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and drive motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and drive motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: An upright vacuum cleaner includes a nozzle assembly, a canister assembly pivotally mounted to said nozzle assembly, a suction fan and drive motor and a biaser. The biaser has a first end that engages the nozzle assembly and a second end that engages the canister assembly. The biaser provides a positive downforce urging the forward end of the nozzle assembly toward the surface being cleaned.

Abstract: The invention features methods for identifying gene products that mediate a phenotype, such as drug resistance or sensitivity, as well as methods for identifying new bioactive compounds, by detecting differences in sensitivity of growth rate between host cells that differ in target gene product dosage (e.g., two copies of a target gene product-encoding sequence compared to one copy).

Abstract: A gel electrophoresis method and apparatus is described in which the shape and orientation of the electric field is controlled by contour clamping. Electrodes are arranged around a closed contour. Two or more electrodes, the driving electrodes, are clamped at a potential difference .phi..sub.0 to establish the general orientation and strength of the electric field. The remaining electrodes are clamped to intermediate potentials to control the shape of the field established by the driving electrodes. The field is varied in accordance with the purpose of the electrophoresis, depending upon the size of the particles and the information to be determined concerning the particles.

Abstract: A gel electrophoresis method and apparatus is described in which the shape and orientation of the electric field is controlled by contour clamping. Electrodes are arranged around a closed contour. Two or more electrodes, the driving electrodes, are clamped at a potential difference .phi..sub.0 to establish the general orientation and strength of the electric field. The remaining electrodes are clamped to intermediate potentials to control the shape of the field established by the driving electrodes. The field is varied in accordance with the purpose of the electrophoresis, depending upon the size of the particles and the information to be determined concerning the particles.