Abstract: The present invention provides apparatus and methods for the delivery of therapeutic agents to target tissues by electromigration. The utilization of electric fields according to the methods of the invention aids in the distribution and targeting of therapeutic agents, in particular, where standard means of agent application in the target tissue is insufficient to achieve prophylactic or therapeutic results. In particular embodiments, the present invention utilizes a convective force in combination with the developed electric fields to further increase the flux of the therapeutic agent or to further improve distribution of the therapeutic agent within the target tissues.