Abstract: A method is disclosed for operating an electrostatic applicator system, including inserting a disposable cartridge into a chamber housing of the electrostatic applicator system such that a voltage contact at a first end of a voltage wire within the first disposable cartridge contacts a voltage contact of the electrostatic applicator system; and a first end of an air supply tube within the first disposable cartridge fluidly connects with an air supply port of the electrostatic applicator system; and causing, by an activation input to the electrostatic applicator system, a motor to actuate and a voltage potential to be delivered to a delivery tube of the first disposable cartridge.

Abstract: A nozzle housing is disclosed for a disposable fluid delivery system of an electrostatic applicator. The nozzle housing includes an air supply inlet port configured to be in fluid communication with and receive a nozzle end of an air supply tube. A voltage cavity port is configured to receive a tube with a voltage wire. A delivery outlet can be at a distal end of the nozzle housing opposite a luer inlet port, the delivery outlet configured to receive a delivery tube of a luer and in fluid communication with the air supply inlet port.

Abstract: The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (Compound A).

Abstract: A disposable fluid delivery system for an electrostatic applicator. The system includes a nozzle cap including a distal end including a delivery outlet and an open proximal end. A nozzle housing can be included with a proximal inlet end and an open distal end connected to the open proximal end of the nozzle cap. A conductive insert is at least partially positioned between the open distal end and the proximal inlet end and includes a portion of a flow pathway formed at least partially between the nozzle cap, the nozzle housing, and the conductive insert. A high voltage connector is extended at least partially through the nozzle housing and electrically connected to the conductive insert and configured to be in electrical communication with a high voltage module and electrostatically charge fluid contents within the flow pathway.

Abstract: A disposable fluid delivery system for an electrostatic applicator, is disclosed. The system can include a cartridge housing to store an aqueous solution and a nozzle housing. A high voltage contact can be electrically attached to a delivery tube at least partially within the nozzle housing, the high voltage contact in electrical communication with a high voltage module and configured to electrostatically charge fluid contents within the delivery tube. A cartridge retention system can be positioned at least partially with an outer surface of the cartridge housing, the cartridge retention system configured to engage with and retain the cartridge housing in a connected configuration with a cartridge receiving chamber of an applicator housing of the electrostatic applicator.

Abstract: In some embodiments, the present disclosure relates to multicomponent complexes, such as salts, of Compound 1, and hydrates and solvates thereof. In some embodiments, the present disclosure relates to pharmaceutically acceptable salts of Compound 1, and hydrates and solvates thereof. In some embodiments, the present disclosure relates to crystalline complexes comprising Compound 1 (free base) and a coformer, and hydrates and solvates thereof. In some embodiments, the present disclosure relates to a crystalline salt of Compound 1 comprising Compound 1 (free base) and a salt coformer, and hydrates and solvates thereof. In some embodiments, the present disclosure relates to crystalline forms of Compound 1 (free base), and hydrates and solvates thereof. In some embodiments, the present disclosure relates to compositions, dosage forms, and kits comprising a multicomponent complex as disclosed herein.

Abstract: A nozzle housing is disclosed for a disposable fluid delivery system of an electrostatic applicator. The nozzle housing includes an air supply inlet port configured to be in fluid communication with and receive a nozzle end of an air supply tube. A voltage cavity port is configured to receive a tube with a voltage wire. A delivery outlet can be at a distal end of the nozzle housing opposite a luer inlet port, the delivery outlet configured to receive a delivery tube of a luer and in fluid communication with the air supply inlet port.

Abstract: A disposable fluid delivery system for an electrostatic applicator. The system includes a nozzle housing comprising an air supply port, a voltage port, and a delivery outlet. A voltage wire has a contact in communication with a delivery tube in fluid communication with the delivery outlet. A syringe includes a barrel portion and a plunger configured to advance fluids from within the barrel portion and through the delivery tube. A cartridge housing can at least partially enclose the nozzle housing, the voltage wire, and the syringe.

Abstract: The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (Compound A).