Abstract: Provided is a system (300) for determining a sweat rate per gland and measuring biomarker concentration. The system comprises an apparatus and a sensor (166). The apparatus receives sweat from the skin and transports the sweat as discrete sweat droplets to the sensor. The sensor senses each of the counted sweat droplets. The system further comprises a processor which counts the number of sensed sweat droplets during a time period. The processor also determines time intervals between consecutive sensed sweat droplets, and receives a measure of the volume of each of the counted sweat droplets. The time intervals and the measure of the volume are then used by the processor to identify sweat burst and rest periods of the sweat gland or glands producing the sweat. This identification process necessarily involves assigning the sweat burst and rest periods to the sweat gland or glands, such that the processor is permitted to determine the number of sweat glands involved in producing the sweat.

Abstract: Provided is an apparatus (100) for transporting sweat droplets (112) to a sensor. The apparatus comprises a chamber (102) for filling with sweat. The chamber has an inlet (104) lying adjacent the surface of the skin (106), which inlet permits sweat to enter and fill the chamber. The chamber has an outlet (114) from which a sweat droplet protrudes once the chamber has been filled. The apparatus further comprises a fluid transport assembly which is designed to enable the sweat droplet protruding from the outlet to become detached from the outlet of the chamber. The sweat droplet is subsequently transported by the fluid transport assembly to the sensor. Once the protruding droplet has been released from the outlet, the outlet is made available for a subsequent sweat droplet to protrude therefrom upon further filling of the chamber.

Abstract: According to an aspect, there is provided a system (10) comprising a sweat stimulation device (100) for stimulating sweat generation from sweat glands of a subject, the device comprising: a stimulation element (102) configured to provide modulated stimulation between two non-zero states to the sweat glands through the skin of the subject; and a sensor (104) for measuring data indicative of a characteristic of sweat generated by the sweat glands in response to the stimulation; and a processor (110) configured to receive the measured data from the sensor; compare the measured data with a threshold value; and responsive to determining that the measured data meets or exceeds the threshold value, generate an alert signal.

Abstract: According to an aspect, there is provided switch circuitry (1) for controlling power supplied to a fluid monitoring unit (4). The switch circuitry (1) comprises: a sensor (2) configured to detect fluid derived from the skin of a user and to generate a detection signal in response to detection of fluid; and a controller (3) configured to receive the detection signal, to generate a wake-up signal in accordance with the detection signal, and to supply the wake-up signal to a switch (6) controlling the power supply to the fluid monitoring unit (4) so as to activate the switch (6) and wake the fluid monitoring unit (4), wherein, optionally, the fluid is sweat. According to another aspect, there is provided method of controlling power to a fluid monitoring unit.

Abstract: A patient monitoring method comprises receiving (103, 109) input data indicative of shivering episodes (52) and sweating episodes (54) of a patient; recording (105, 111) the respective points in time at which the shivering episodes and sweating episodes occur; and generating (115, 117) an output based on an alternating pattern of the shivering episodes and sweating episodes from the recorded respective points in time of the respective shivering and/or episodes. Also disclosed is a computer program product for implementing such a method and a monitoring system (10) arranged to implement such a method.

Abstract: A patient monitoring system comprising a memory (104) comprising instruction data representing a set of instructions (106) and a processor (102) configured to communicate with the memory and to execute the set of instructions. The set of instructions, when executed by the processor, cause the processor to obtain patient data about a patient being monitored by the patient monitoring system, obtain previous patient data, determine a difference between the patient data and the previous patient data; and send a message to a user display associated with the patient monitoring system, to cause the user display to adapt content displayed on the user display, based on the determined difference.

Abstract: In an embodiment, a computer-implemented method (100) is described. The method comprises receiving (102) a request associated with a user for information about a client. The method further comprises, in response to the request, generating (104) information indicative of at least one interaction between at least one caregiver and a client context associated with the client based on interaction data obtained responsive to the at least one interaction. The generated information is customized to the user based on a user profile associated with the user.

Abstract: Provided is a sweat sensing device (100). The device comprises a body (102) for positioning against skin (104). A recess (108) is defined in the body for receiving sweat from a skin area. The device further comprises an optical detection assembly (114) configured to detect a discrete sweat droplet (106) protruding into the recess from a sweat pore (110) in the skin area, and a fluidic system (116) configured to transport the sweat droplet (106) away from the recess (108) following detection of the sweat droplet by the optical detection assembly (114).

Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more interleukin genes selected from the group consisting of: IL17RE, IL1B, IL3, IL7R, IL9R, and EBI3, said gene expression profiles being determined in a biological sample obtained from the subject, and determining, preferably by a processor, the prediction of the radiotherapy response based on the gene expression profiles for the three or more interleukin genes.

Abstract: The present invention relates to body fluid monitoring. It is proposed to incorporate a reagent-free calibration method into a patch or wearable. The method comprises capturing molecules of interest, i.e. calibration molecules inside the bioliquid of the patient, and release them when needed for calibration. This eliminates the need for onboard reagent storage. Because the calibration is done in the same bioliquid, any matrix effects are corrected for.

Abstract: The present invention relates to biofluid monitoring. It is proposed to use a system (100) and a method to detect when a biomarker sensor (10) with a regenerable surface (14) has degraded and/or predicting when the sensor will degrade. At least one of the following methods are used for the detection: counting the number of times the surface has been regenerated, determining the cumulative amount of biomolecules measured with the device, detecting an increased/decreased voltage change or pH change needed to release the biomarkers from the capture surface, detecting deviations of the sensor raw signal signatures from factory calibration signals, and using tracer analyte molecules comprising analyte molecules bound to magnetic beads.

Abstract: According to an aspect, there is provided a computer implemented method for processing data relating to a subject, the method comprising: generating a first query based on contextual information relating to a subject; receiving, from a user, a second query relating to the subject; and processing the first query and the second query to generate an output comprising at least one of: a request for further input from a user; an indication of clinical information relevant to the subject.

Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of five or more immune defense response genes selected from the group consisting of: AIM2, APOBEC3A, CIAO1, DDX58, DHX9, IFI16, IFIH1, IFIT1, IFIT3, LRRFIP1, MYD88, OAS1, TLR8, and ZBP1, said gene expression profiles being determined in a biological sample obtained from the subject, and determining, by a processor, the prediction of the radiotherapy response based on the gene expression profiles for the five or more immune defense response genes.

Abstract: Provided is a method (400) of positioning a sweat sensor device (100), the method comprising: determining (410) a first skin location (i) of a mammalian subject, which first skin location (i) contains apocrine and eccrine sweat glands; determining (420) a second skin location (ii), adjacent to the first skin location (i), and having a different sweat gland composition than the first skin location, wherein at the second skin location (ii), predominantly eccrine sweat glands are present, and wherein the determining (410, 420) of the first (i) and second (it) skin locations is achieved by detecting differences between the first (i) and second (ii) skin locations; and positioning (430) the sweat sensor device (100) such that a first part of the sweat sensor device (100) is present on the first skin location (i), while a second part of the sweat sensor device (100) is present on the second skin location (ii).

Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of eight or more T-Cell receptor signaling genes selected from the group consisting of: CD2, CD247, CD28, CD3E, CD3G, CD4, CSK, EZR, FYN, LAT, LCK, PAG1, PDE4D, PRKACA, PRKACB, PTPRC, and ZAP70, said gene expression profiles being determined in a biological sample obtained from the subject, and determining, by a processor, the prediction of the radiotherapy response based on the gene expression profiles for the eight or more T-Cell receptor signaling genes.

Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of two or more DNA repair genes selected from the group consisting of: APTX, BRCA2, NUDT1, PMS2, and POLD2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining, by a processor, the prediction of the radiotherapy response based on the gene expression profiles for the two or more DNA repair genes.

Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of one or more chemokine genes selected from the group consisting of: CCL2 and CXCL17, said gene expression profile(s) being determined in a biological sample obtained from the subject, and determining, by a processor, the prediction of the radiotherapy response based on the gene expression profile(s) for the one or both chemokine genes.

Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of two or more immune checkpoint genes selected from the group consisting of: LAG3, LGALS9, TDO2, TMIGD2, and VTCN1, said gene expression profiles being determined in a biological sample obtained from the subject, and determining, by a processor, the prediction of the radiotherapy response based on the gene expression profiles for the two or more immune checkpoint genes.

Abstract: A mechanism for controlling how assistance is provided to a caregiver or clinician. Information about a workload and amount of information available to the caregiver is obtained. This information is processed to determine a recommended level of assistance that should be provided to the caregiver. The operation of an assistance tool, which may be run by a processing system, is modified based upon the recommended level of assistance.

Abstract: Provided is a system for correcting a sweat analyte measurement for temperature. The system comprises a sweat collector (106) for collecting sweat from skin (102). The collected sweat is drawn from the sweat collector to an outlet (110) via a capillary (108). The sweat is drawn through the capillary by capillary action and evaporation of the sweat from the outlet. The evaporation of the sweat from the outlet depends on the temperature. A flow sensor (112) measures a flow rate of the sweat being drawn through the capillary. An analyte sensor (114) obtains the sweat analyte measurement. The system further comprises a controller which is configured to determine a temperature from the measured flow rate. The sweat analyte measurement is then corrected using the determined temperature.