Patents by Inventor Ron Stubbers
Ron Stubbers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9453200Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: GrantFiled: August 28, 2014Date of Patent: September 27, 2016Assignee: INGENERON INCORPORATEDInventors: Ron Stubbers, Michael E. Coleman
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Publication number: 20160272943Abstract: A closed system apparatus and method for isolation and recovery of desired cells from body tissue includes a first container for tissue dissociation by subjection to centrifugation over one or more cycles of rotational acceleration and deceleration, a particle filter to filter out non-dissociated tissue while passing desired cells to a second container for separating the desired cells from connective tissue, unwanted material, liquid, and dissociation-aiding reagent(s) by subjection of the second container to combined centrifugal and gravitational forces that also causes concentration and sedimentation of the cells into a pellet for removal through a valve in the bottom of the second container.Type: ApplicationFiled: December 15, 2015Publication date: September 22, 2016Inventors: Greg Stone, Ron Stubbers, Michael E. Coleman, Eckhard Alt
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Publication number: 20150314041Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: February 10, 2015Publication date: November 5, 2015Applicant: InGeneron IncorporatedInventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
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Publication number: 20150307845Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: February 10, 2015Publication date: October 29, 2015Applicant: InGeneron IncorporatedInventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
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Publication number: 20150299643Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: February 10, 2015Publication date: October 22, 2015Applicant: InGeneron IncorporatedInventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
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Publication number: 20150093809Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: September 27, 2013Publication date: April 2, 2015Applicant: InGeneron, Inc.Inventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
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Publication number: 20150056691Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: ApplicationFiled: August 28, 2014Publication date: February 26, 2015Inventors: Ron Stubbers, Michael E. Coleman
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Methods and apparatus for enhanced recovery of cells and of cell-enriched matrix from tissue samples
Patent number: 8951513Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: GrantFiled: December 16, 2011Date of Patent: February 10, 2015Assignee: Ingeneron IncorporatedInventors: Eckhard U. Alt, Michael E. Coleman, Ron Stubbers -
Publication number: 20150037387Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.Type: ApplicationFiled: October 20, 2014Publication date: February 5, 2015Applicants: Board of Regents of the University of Texas System, Ingeneron, Inc.Inventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
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Patent number: 8865199Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.Type: GrantFiled: November 17, 2009Date of Patent: October 21, 2014Assignees: Ingeneron, Inc., Board of Regents of the University of Texas SystemInventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
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Patent number: 8822202Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: GrantFiled: October 26, 2012Date of Patent: September 2, 2014Assignee: Ingeneron IncorporatedInventors: Ron Stubbers, Michael Coleman
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Publication number: 20130337551Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: ApplicationFiled: October 26, 2012Publication date: December 19, 2013Applicant: InGeneron Inc.Inventors: Ron Stubbers, Michael Coleman
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Publication number: 20130115697Abstract: This document describes methods and an apparatus for recovery of cells from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: November 3, 2011Publication date: May 9, 2013Inventors: Eckhard U. Alt, Michael E. Coleman, Ron Stubbers
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Patent number: 8309342Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: GrantFiled: December 3, 2008Date of Patent: November 13, 2012Assignee: InGeneron, Inc.Inventors: Ron Stubbers, Michael E. Coleman
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METHODS AND APPARATUS FOR ENHANCED RECOVERY OF CELLS AND OF CELL-ENRICHED MATRIX FROM TISSUE SAMPLES
Publication number: 20120195863Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: December 16, 2011Publication date: August 2, 2012Inventors: Eckhard U. Alt, Michael E. Coleman, Ron Stubbers -
Publication number: 20100285588Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: ApplicationFiled: December 3, 2008Publication date: November 11, 2010Applicant: INGENERON, INC.Inventors: Ron Stubbers, Michael E. Coleman
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Publication number: 20100124563Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.Type: ApplicationFiled: November 17, 2009Publication date: May 20, 2010Applicant: InGeneron, Inc.Inventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
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Patent number: 5012808Abstract: A pulse generation and tracking system for connection to an object or a subject under treatment therewith, the waveform being a train of repetitive complex pulses each pulse comprising a large amplitude, short duration positive polarity portion and a small amplitude, long duration negative polarity portion, and a zero value portion. The prescribed pulse train for a subject is delivered by a delivery device, which also provides monitoring of the averaged voltage amplitude of the positive portion in terms of either voltage or current value. The impedance of the subject is expected to change over time and cause the individual pulses to vary from predetermined limits. When this occurs, then a subsequent generation of pulses will be changed so that the pulses are again delivered within the predetermined value limits or boundary. Tracking and generation can be operationally crossed, if desired, so that a voltage out of boundary will cause the current of a subsequent pulse to be changed or vice versa.Type: GrantFiled: October 17, 1988Date of Patent: May 7, 1991Assignee: Zion Educational FoundationInventors: Ron Stubbers, Chen Chen, Malcolm Skolnick
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Patent number: 4779044Abstract: A regularly repetitive, almost periodic but non-regularly shaped waveform is amplitude sampled at an interval different from that of the waveform under investigation. For a voltage measurement, the positive samples are averaged for a predetermined count number (one set) and the negative samples are likewise averaged. Zero value samples are ignored. The highest absolute value of the two is taken as a meaningful measurement. Alternatively, one of these values can be selected. For a current measurement, a running average for a predetermined number of sets can also be developed. Finally, frequency can be developed by sensing the transitions and operating a counter on/off at the beginning and ending of a waveform cycle. The count of regular interval counts is then multiplied by the interval time to give the period of the waveform. The reciprocal of the period is a measure of the frequency.Type: GrantFiled: September 8, 1987Date of Patent: October 18, 1988Assignee: Zion Educational FoundationInventors: Malcolm Skolnick, Ron Stubbers, Chris Hymel, Chen Chen