Patents by Inventor Ronald A. Graham

Ronald A. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLEAVABLE DISULFIDE LINKERS AND USES THEREOF
    Publication number: 20250101512
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage in situ.
    Type: Application
    Filed: November 15, 2024
    Publication date: March 27, 2025
    Inventors: Ronald Graham, Megha Cila
  • COMPOSITIONS AND METHODS FOR SERIAL TARGET DETECTION
    Publication number: 20250085276
    Abstract: Disclosed herein, inter alia, are methods and compositions useful for serially detecting multiple biological targets.
    Type: Application
    Filed: September 10, 2024
    Publication date: March 13, 2025
    Inventors: Eli N. Glezer, Ronald Graham
  • FLUORINATED NUCLEOTIDES AND USES THEREOF
    Publication number: 20250084120
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 13, 2025
    Inventors: Ronald Graham, Andrew Spaventa, Eli N. Glezer
  • Fluorinated nucleotides and uses thereof
    Patent number: 12215124
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: February 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Andrew Spaventa, Eli Glezer
  • Nucleotide analogues
    Patent number: 12215122
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: November 29, 2023
    Date of Patent: February 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Cleavable disulfide linkers and uses thereof
    Patent number: 12188089
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
    Type: Grant
    Filed: February 12, 2024
    Date of Patent: January 7, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Megha Cila
  • PHOTOSTABLE DETECTABLE COMPOUNDS
    Publication number: 20240410892
    Abstract: Disclosed herein, inter alia, are detectable compounds including a triplet state quencher and the method of use thereof.
    Type: Application
    Filed: May 30, 2024
    Publication date: December 12, 2024
    Inventors: Michael Krause, Ronald Graham
  • NUCLEOTIDE ANALOGUES
    Publication number: 20240400602
    Abstract: Disclosed herein, inter alia, are compounds and methods of using the same for the modifying a nucleic acid molecule.
    Type: Application
    Filed: July 31, 2024
    Publication date: December 5, 2024
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • METHODS AND COMPOSITIONS USEFUL FOR NUCLEIC ACID SEQUENCING
    Publication number: 20240392348
    Abstract: Disclosed herein, inter alia, are modified nucleotides and methods of using the same in nucleic acid sequencing reactions.
    Type: Application
    Filed: August 7, 2024
    Publication date: November 28, 2024
    Inventors: Eli N. Glezer, Ronald Graham, Michael J. Krause
  • Nucleotide analogues
    Patent number: 12145960
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: November 19, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • REDUCING AGENTS AND USES THEREOF
    Publication number: 20240368202
    Abstract: Disclosed herein, inter alia, are reducing agents and methods of use thereof.
    Type: Application
    Filed: June 24, 2024
    Publication date: November 7, 2024
    Inventors: Ronald Graham, Zachary Terranova
  • CLEAVABLE DISULFIDE LINKERS AND USES THEREOF
    Publication number: 20240327907
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
    Type: Application
    Filed: February 12, 2024
    Publication date: October 3, 2024
    Inventors: Ronald Graham, Megha Cila
  • DISULFIDE CONTAINING THERAPEUTICS AND DIAGNOSTICS
    Publication number: 20240316036
    Abstract: Disclosed herein, inter alia, are therapeutic and theragnostic compounds and methods of use thereof.
    Type: Application
    Filed: February 14, 2024
    Publication date: September 26, 2024
    Inventors: Ronald Graham, Surya Adhikari
  • RHODAMINE FLUORESCENT COMPOUNDS AND PRODUCTION METHODS THEREOF
    Publication number: 20240294764
    Abstract: Disclosed herein, inter alia, are fluorescent compounds and methods of making and using thereof.
    Type: Application
    Filed: February 7, 2024
    Publication date: September 5, 2024
    Inventors: Ada Tong, Megha Cila, Ronald Graham
  • SILICON CONTAINING DETECTABLE COMPOUNDS AND USES THEREOF
    Publication number: 20240279479
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Application
    Filed: March 29, 2024
    Publication date: August 22, 2024
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • DISULFIDE CONTAINING THERAPEUTICS
    Publication number: 20240269156
    Abstract: Disclosed herein, inter alia, are methods and compounds including cleavable moieties, and methods of use thereof.
    Type: Application
    Filed: December 18, 2023
    Publication date: August 15, 2024
    Inventors: Ronald Graham, Surya Adhikari
  • NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
    Publication number: 20240271205
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: March 7, 2024
    Publication date: August 15, 2024
    Inventors: Ronald GRAHAM, Olga ADELFINSKAYA, Megha CILA, Rodrigo RODRIGUEZ
  • Reducing agents and uses thereof
    Patent number: 12054506
    Abstract: Disclosed herein, inter alia, are novel reducing agents having the general formula and methods of use thereof.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: August 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Zachary Terranova
  • NUCLEOTIDE ANALOGUES
    Publication number: 20240174709
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: November 29, 2023
    Publication date: May 30, 2024
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Silicon containing detectable compounds and uses thereof
    Patent number: 11987709
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: May 21, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez