Patents by Inventor Ronald A. Nixon

Ronald A. Nixon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190055281
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: February 6, 2018
    Publication date: February 21, 2019
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Patent number: 9856287
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: January 2, 2018
    Assignee: Amgen Inc.
    Inventors: Joseph Edward Shultz, Roger Hart, Ronald Nixon Keener, III
  • Publication number: 20170145049
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 25, 2017
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Publication number: 20150329586
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L, or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox butler strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: July 7, 2015
    Publication date: November 19, 2015
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Publication number: 20150315232
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying foe thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: January 30, 2015
    Publication date: November 5, 2015
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Patent number: 8952138
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: February 10, 2015
    Assignee: Amgen Inc.
    Inventors: Joseph Edward Shultz, Roger Hart, Ronald Nixon Keener, III
  • Publication number: 20100324269
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: June 21, 2010
    Publication date: December 23, 2010
    Applicant: AMGEN INC.
    Inventors: Joseph Edward Shultz, Roger Hart, Ronald Nixon Keener, III
  • Patent number: 5428338
    Abstract: A thermal cutoff encapsulated in potting material within a dielectric tubular housing having an oval cross-sectional shape and a flat closed end. The thermal cutoff has a cylindrical body located intermediate the open and closed ends of the tubular housing, and the longitudinal axis of the thermal cutoff body is parallel to and laterally offset from the longitudinal axis of the tubular housing.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: June 27, 1995
    Assignee: Therm-O-Disc, Incorporated
    Inventors: Ronald A. Nixon, Harry M. Crease, Lewis W. Smith
  • Patent number: 5015987
    Abstract: Wires and a thermistor are isolated from the interior surface of a metal tube by a ceramic tube and a ceramic spacer to protect the thermistor and prevent breakdown of insulation on the wires.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: May 14, 1991
    Assignee: Therm-O-Disc, Incorporated
    Inventors: Ronald A. Nixon, Marc A. Peoples, Emil R. Plasko
  • Patent number: 4968962
    Abstract: A thermal cutoff and a heating resistor are assembled in heat transfer relationship with one another by a metal clip. The assembly is mounted on a base of dielectric material. Electric leads on the thermal cutoff and resistor extend through holes in the base for connection to a printed circuit board.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: November 6, 1990
    Assignee: Therm-O-Disc, Incorporated
    Inventors: David A. Hohider, Ronald A. Nixon
  • Patent number: 4948931
    Abstract: A combined pressure cutoff and pressure relief valve includes a normally closed switch movable between closed and open contact positions. A normally closed pressure relief vent is located in a common housing with the switch. A pressure responsive diaphragm applies force to a switch snap disc and a vent snap disc. Under high pressure conditions, the switch snap disc snaps and opens a pair of contacts. In the event an abnormal pressure condition occurs, the vent snap disc operates and causes a pin to rupture the diaphragm for opening the relief vent.
    Type: Grant
    Filed: April 17, 1989
    Date of Patent: August 14, 1990
    Assignee: Therm-O-Disc, Incorporated
    Inventors: Ronald A. Nixon, Charles Yagher, Jr.
  • Patent number: 4837547
    Abstract: A thermal cutoff is mounted adjacent a bleed opening in a hot air duct. Hot air flowing through the bleed opening mixes with ambient air before contacting the thermal cutoff. If a predetermined air temperature is exceeded, the thermal cutoff operates, and de-energizes the air heater.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: June 6, 1989
    Assignee: Therm-O-Disc, Incorporated
    Inventors: Ronald A. Nixon, Charles Yagher, Jr.
  • Patent number: 4808960
    Abstract: A thermal cutoff having a metal foil resistance heater circuit bonded to its outer surface.
    Type: Grant
    Filed: November 6, 1987
    Date of Patent: February 28, 1989
    Assignee: Therm-O-Disc, Incorporated
    Inventor: Ronald A. Nixon
  • Patent number: PP15218
    Abstract: An asexually reproduced variety of perennial zoysiagrass with a unique combination of characters including fine to medium leaf blade width, and low floral production.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: October 12, 2004
    Inventor: Ronald Nixon