Patents by Inventor Ronald A. Smaldone

Ronald A. Smaldone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CONTROLLED DELIVERY AND PROTECTION OF THERAPEUTIC AGENTS
    Publication number: 20230001396
    Abstract: In some aspects, the present disclosure provides pharmaceutical compositions comprising a) a therapeutic agent; b) a metal-organic framework (MOF) or a coordination polymer; and c) a pharmaceutically acceptable polymer; wherein the therapeutic agent is encapsulated within the metal-organic framework or coordination polymer to form an encapsulated therapeutic agent, and wherein the encapsulated therapeutic agent is further encapsulated, entrapped, embedded, dispersed within, or complexed to the pharmaceutically acceptable polymer. The present disclosure also provides methods of making said compositions, methods of treating a disease or disorder comprising administering to a subject said compositions. The present disclosure also provides microneedles and implantable medical devices comprising said compositions.
    Type: Application
    Filed: November 13, 2020
    Publication date: January 5, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jeremiah J. GASSENSMITH, Michael LUZURIAGA, Ronald SMALDONE
  • Nanoporous carbohydrate frameworks and the sequestration and detection of molecules using the same
    Patent number: 10125016
    Abstract: Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: November 13, 2018
    Assignee: Northwestern University
    Inventors: J. Fraser Stoddart, Ronald A. Smaldone, Ross S. Forgan, Jeremiah J. Gassensmith
  • MELT-PROCESSABLE THERMOSET POLYMERS, METHOD OF SYNTHESIS THEREOF AND USE IN FUSED FILAMENT FABRICATION PRINTING
    Publication number: 20180051113
    Abstract: A melt-processable thermoset polymer comprising monomers cross-linked together by furan-maleimide Diels Alder adduct covalent bonds. At least about 1 percent of the furan-maleimide Diels Alder adduct covalent bonds of the polymer are de-cross-linked by a retro Diels Alder reaction at a temperature in a range from about 90° C. and less than about 300° C. A method of synthesizing, a filament fabrication printer for printing, and a method of printing, the melt-processable thermoset polymer are also disclosed.
    Type: Application
    Filed: March 13, 2017
    Publication date: February 22, 2018
    Inventors: Kejia Yang, Benjamin R. Lund, Ronald Smaldone, Walter Voit
  • Nanoporous Carbohydrate Frameworks and the Sequestration and Detection of Molecules Using the Same
    Publication number: 20150322174
    Abstract: Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.
    Type: Application
    Filed: July 20, 2015
    Publication date: November 12, 2015
    Inventors: J. Fraser Stoddart, Ronald A. Smaldone, Ross S. Forgan, Jeremiah J. Gassensmith
  • Nanoporous carbohydrate frameworks and the sequestration and detection of molecules using the same
    Patent number: 9085460
    Abstract: Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: July 21, 2015
    Assignee: Northwestern University
    Inventors: J. Fraser Stoddart, Ross S. Forgan, Ronald A. Smaldone, Jeremiah J. Gassensmith
  • NANOPOROUS CARBOHYDRATE FRAMEWORKS AND THE SEQUESTRATION AND DETECTION OF MOLECULES USING THE SAME
    Publication number: 20120070904
    Abstract: Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.
    Type: Application
    Filed: March 17, 2011
    Publication date: March 22, 2012
    Inventors: J. Fraser Stoddart, Ross S. Forgan, Ronald A. Smaldone, Jeremiah J. Gassensmith