Abstract: A process for making a folded composition-eluting balloon catheter includes coating one or both surfaces of a one or more foldable wings with a hydrophilic coating, applying a composition as a coating on the coated surface and providing the composition within a fold of the one or more foldable wings, and folding the one or more foldable wings to seal the composition by the one or more foldable wings to prevent/reduce its release until after inflation of the balloon. Another process for making a folded composition-eluting balloon catheter includes coating one or both surfaces of the one or more foldable wings with a hydrophilic coating-composition mixture and providing the composition by the one or more foldable wings, and folding the one or more foldable wings to seal the composition between the fold of the one or more foldable wings to prevent/reduce its release until after an inflation of the balloon.

Abstract: A process for making a folded composition-eluting balloon catheter includes coating one or both surfaces of a one or more foldable wings with a hydrophilic coating, applying a composition as a coating on the coated surface and providing the composition within a fold of the one or more foldable wings, and folding the one or more foldable wings to seal the composition by the one or more foldable wings to prevent/reduce its release until after inflation of the balloon. Another process for making a folded composition-eluting balloon catheter includes coating one or both surfaces of the one or more foldable wings with a hydrophilic coating-composition mixture and providing the composition by the one or more foldable wings, and folding the one or more foldable wings to seal the composition between the fold of the one or more foldable wings to prevent/reduce its release until after an inflation of the balloon.

Abstract: The present invention relates to a composition-eluting balloon catheter (100) having a proximal (20) and distal (15) end, comprising an elongated catheter tube (6) with an inflation lumen (7) extending therewithin and at least one inflatable balloon (4) towards the distal end (15) in fluid communication with the inflation lumen (7), wherein the balloon (4) in the uninflated condition is provided as one or a plurality of folded wings (10?, 10?), and composition (12?, 12?) is provided essentially exclusively within the folds of the wings (10?, 10?), wherein the balloon (4) in the uninflated condition is further provided with a relief structure (30) comprising at least one groove on the outside of the folded wings (10?, 10?), configured to substantially reduce in depth in an inflated state of the balloon (4), and whereby the at least one groove is essentially devoid of composition (12?, 12?).

Abstract: A stent provided with a composition comprising melatonin and paclitaxel is described. The described stent is useful in treating smooth muscle cell proliferation, such as stenosis and preventing restenosis in vascular vessels.

Abstract: A stent is provided with a composition which includes melatonin and paclitaxel for use in treating smooth muscle cell proliferation, such as stenosis and preventing restenosis in vascular vessels.

Abstract: The invention relates to a balloon catheter comprising a catheter tube having a first lumen and a second lumen, each lumen having a proximal end and a distal end, an inflatable balloon having a proximal end and a distal end, and a guide wire receivable in the second lumen. The distal end of the first lumen opens into the balloon. The distal end of the second lumen is open and positioned proximally of the proximal end of the balloon.

Abstract: A balloon (60) is attached to a catheter tube (62). A stiffening wire (64) extends from the catheter tube (62) to a tip (66). A lumen (70) is provided at the end of a flexible tube that at its opposite end is attached to the catheter tube (62). When the balloon (60) is deflated, the tube (72) is straight. When the balloon (60) is inflated, the tube (72) bends around the balloon (60).