Patents by Inventor Ronald B. Wetzel

Ronald B. Wetzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of making antibody heavy and light chains having specificity for a desired antigen
    Patent number: 7923221
    Abstract: The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: April 12, 2011
    Assignees: Genentech, Inc, City of Hope
    Inventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
  • Methods of producing immunoglobulins, vectors and transformed host cells for use therein
    Patent number: 6331415
    Abstract: The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.
    Type: Grant
    Filed: June 10, 1988
    Date of Patent: December 18, 2001
    Assignee: Genentech, Inc.
    Inventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
  • Recombinant immunoglobin preparations
    Patent number: 4816567
    Abstract: Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglobulins into immunologically active form.
    Type: Grant
    Filed: April 8, 1983
    Date of Patent: March 28, 1989
    Assignee: Genentech, Inc.
    Inventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
  • Purification and activity assurance of precipitated heterologous proteins
    Patent number: 4599197
    Abstract: A heterologous expression product in host cells is separated from the host cell material by suspending the material in a buffered solution, disrupting the cells and separating the product as refractile material. The refractile material can be dissolved in a strongly denaturing solution, which is then weakened while keeping the protein in solution, thereby allowing unfolding and refolding of the protein.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: July 8, 1986
    Assignee: Genentech, Inc.
    Inventor: Ronald B. Wetzel