Patents by Inventor Ronald Buckanovich

Ronald Buckanovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule inhibitors of ALDH and uses thereof
    Patent number: 11944626
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 2, 2024
    Assignees: The Regents of the University of Michigan, Indiana University Research and Technology Corporation
    Inventors: Scott D. Larsen, Brandt C. Huddle, Kun Yang, Ronald Buckanovich, Thomas Hurley
  • SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF
    Publication number: 20190255055
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 22, 2019
    Inventors: Scott D. Larsen, Brandt C. Huddle, Kun Yang, Ronald Buckanovich, Thomas Hurley
  • COMPOSITIONS AND METHODS RELATING TO INHIBITING CANCER CELL GROWTH AND/OR PROLIFERATION
    Publication number: 20180162934
    Abstract: The present invention determined that EGFL6 functions as a tumor vascular regulator of ovarian cancer stem cells (CSC). In addition, the present invention determined that a novel EGFL6 blocking antibody was able to restrict cancer cell growth and delay disease recurrence. As such, the present invention provides compositions and methods for inhibiting cancer cell growth, proliferation and/or metastasis. In particular, the present invention provides methods for inhibiting cancer cell growth, proliferation and/or metastasis through administration of a composition comprising an agent capable of inhibiting the function of EGFL6 (e.g., thereby inhibiting related cancer cell growth). In some embodiments, the agent capable of inhibiting the function of EGFL6 is an EGFL6 blocking antibody. The agents and related compositions additionally find use in diagnostic and research settings.
    Type: Application
    Filed: December 7, 2017
    Publication date: June 14, 2018
    Inventor: Ronald Buckanovich
  • Compositions and methods relating to inhibiting cancer cell growth and/or proliferation
    Patent number: 9850300
    Abstract: The present invention determined that EGFL6 functions as a tumor vascular regulator of ovarian cancer stem cells (CSC). In addition, the present invention determined that a novel EGFL6 blocking antibody was able to restrict cancer cell growth and delay disease recurrence. As such, the present invention provides compositions and methods for inhibiting cancer cell growth, proliferation and/or metastasis. In particular, the present invention provides methods for inhibiting cancer cell growth, proliferation and/or metastasis through administration of a composition comprising an agent capable of inhibiting the function of EGFL6 (e.g., thereby inhibiting related cancer cell growth). In some embodiments, the agent capable of inhibiting the function of EGFL6 is an EGFL6 blocking antibody. The agents and related compositions additionally find use in diagnostic and research settings.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: December 26, 2017
    Assignee: The Regents of the University of Michigan
    Inventor: Ronald Buckanovich
  • Methods and compositions for targeting cancer stem cells
    Patent number: 9468632
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 18, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ronald Buckanovich, Scott D. Larsen, Kun Yang
  • COMPOSITIONS AND METHODS RELATING TO INHIBITING CANCER CELL GROWTH AND/OR PROLIFERATION
    Publication number: 20160053006
    Abstract: The present invention determined that EGFL6 functions as a tumor vascular regulator of ovarian cancer stem cells (CSC). In addition, the present invention determined that a novel EGFL6 blocking antibody was able to restrict cancer cell growth and delay disease recurrence. As such, the present invention provides compositions and methods for inhibiting cancer cell growth, proliferation and/or metastasis. In particular, the present invention provides methods for inhibiting cancer cell growth, proliferation and/or metastasis through administration of a composition comprising an agent capable of inhibiting the function of EGFL6 (e.g., thereby inhibiting related cancer cell growth). In some embodiments, the agent capable of inhibiting the function of EGFL6 is an EGFL6 blocking antibody.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 25, 2016
    Inventor: Ronald Buckanovich
  • METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
    Publication number: 20150297577
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 22, 2015
    Inventors: Ronald Buckanovich, Scott D. Larsen, Kun Yang