Patents by Inventor Ronald C. Beavis

Ronald C. Beavis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020152033
    Abstract: A method for determining the probability that a biological molecule identification is random for a chosen significance level and for a particular experimental condition, the method comprising:
    Type: Application
    Filed: February 23, 2001
    Publication date: October 17, 2002
    Inventors: Ronald C. Beavis, David Fenyo
  • Patent number: 5643798
    Abstract: Improved techniques are provided for DNA sequencing, and particularly for sequencing of the entire human genome. Different base-specific reactions are utilized to use different sets of DNA fragments from a piece of DNA of unknown sequence. Each of the different sets of DNA fragments has a common origin and terminates at a particular base along the unknown sequence. The molecular weight of the DNA fragments in each of the different sets is detected by a matrix assisted laser absorption mass spectrometer to determine the sequence of the different bases in the DNA. The methods and apparatus of the present invention provide a relatively simple and low cost technique which may be automated to sequence thousands of gene bases per hour, and eliminates the tedious and time consuming gel electrophoresis separation technique conventionally used to determine the masses of DNA fragments.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 1, 1997
    Assignee: The Rockefeller University
    Inventors: Ronald C. Beavis, Brian T. Chait
  • Patent number: 5453247
    Abstract: Improved techniques are provided for DNA sequencing, and particularly for sequencing of the entire human genome. Different base-specific reactions are utilized to use different sets of DNA fragments from a piece of DNA of unknown sequence. Each of the different sets of DNA fragments has a common origin and terminates at a particular base along the unknown sequence. The molecular weight of the DNA fragments in each of the different sets is detected by a matrix assisted laser absorption mass spectrometer to determine the sequence of the different bases in the DNA. The methods and apparatus of the present invention provide a relatively simple and low cost technique which may be automated to sequence thousands of gene bases per hour, and eliminates the tedious and time consuming gel electrophoresis separation technique conventionally used to determine the masses of DNA fragments.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: September 26, 1995
    Assignee: The Rockefeller University
    Inventors: Ronald C. Beavis, Brian T. Chait
  • Patent number: 5288644
    Abstract: A method for DNA sequencing, and particularly for sequencing of the entire human genome. Different base-specific reactions are utilized to use different sets of DNA fragments from a piece of DNA of unknown sequence. Each of the different sets of DNA fragments has a common origin and terminates at a particular base along the unknown sequence. The molecular weight of the DNA fragments in each of the different sets is detected by a matrix assisted laser absorption mass spectrometer to determine the sequence of the different bases in the DNA. The methods and apparatus of the present invention provide a relatively simple and low cost technique which may be automated to sequence thousands of gene bases per hour, and eliminates the tedious and time consuming gel electrophoresis separation technique conventionally used to determine the masses of DNA fragments.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: February 22, 1994
    Assignee: The Rockefeller University
    Inventors: Ronald C. Beavis, Brian T. Chait
  • Patent number: 5062935
    Abstract: When vaporizing a sample substance consisting of big molecules, in particular for the purpose of mass-spectroscopic examinations, the energy introduced for the vaporization process may lead to thermolytic decomposition of the sample substance. In order to prevent such decomposition, the invention proposes that the sample substance be mixed, prior to its irradiation, with a matrix material which is easily decomposed under the influence of the laser beam pulses. The matrix may consist of a material which absorbs the radiation and which is easily decomposed thermolytically, or else of a material which is permeable to laser radiation, but mixed with a metal powder. When the mixture is exposed to laser beam pulses, the instable matrix material will decompose first whereby the embedded molecules of the sample substance are set free. It is possible in this manner to prevent, practically completely, the molecules of the sample substance from being destructed.
    Type: Grant
    Filed: March 21, 1989
    Date of Patent: November 5, 1991
    Assignee: Bruker-Franzen Analytik GmbH
    Inventors: Edward W. Schlag, Josef Lindner, Ronald C. Beavis, Jurgen Grotemeyer
  • Patent number: 5045694
    Abstract: In mass spectrometry, a time of flight (TOF) mass spectrometer is used to measure the mass spectrum of organic molecules of mass ranging from 200 Dalton to greater than 200,000 Dalton. Ions from the sample are desorbed by striking the probe tip with laser pulses in a spot size, on the tip, in the range of 0.03-3.0 mm.sup.2. The time of flight of the ions is measured and displayed with a resolution of the ion molecular signal in the range of 300-500 full width at half-maximum definition (FWHM).
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: September 3, 1991
    Assignee: The Rockefeller University
    Inventors: Ronald C. Beavis, Brian T. Chait