Patents by Inventor Ronald C. Bernotas

Ronald C. Bernotas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
    Patent number: 7645752
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5-hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: January 12, 2010
    Assignee: Wyeth LLC
    Inventors: Robert E. McDevitt, Yanfang Li, Albert J. Robichaud, Gavin D. Heffernan, Richard D. Coghlan, Ronald C. Bernotas
  • Quinolines and pharmaceutical compositions thereof
    Patent number: 7576215
    Abstract: This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: August 18, 2009
    Assignee: Wyeth
    Inventors: Michael D. Collini, Robert R. Singhaus, Jr., Baihua Hu, James W. Jetter, Robert L. Morris, David H. Kaufman, Christopher P. Miller, John W. Ullrich, Rayomand J. Unwalla, Jay E. Wrobel, Elaine Quinet, Ponnal Nambi, Ronald C. Bernotas, Merle Elloso
  • Sulfonyl Substituted 1H-Indoles as Ligands for the 5-Hydroxytryptamine Receptors
    Publication number: 20070203120
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5-hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.
    Type: Application
    Filed: January 12, 2007
    Publication date: August 30, 2007
    Applicant: Wyeth
    Inventors: Robert E. McDevitt, Yanfang Li, Albert J. Robichaud, Gavin D. Heffernan, Richard D. Coghlan, Ronald C. Bernotas
  • Sulfuric acid mono-[ 3- ( {1- [ 2- (4-fluoro-phenyl ) -ethyl ] -piperidin-4-YL} -hydroxy-methyl) -2-methoxy-phenyl ] ester
    Publication number: 20030087932
    Abstract: The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and a processes for its preparation and its use in the treatment for a number of disease states.
    Type: Application
    Filed: July 22, 2002
    Publication date: May 8, 2003
    Inventors: Ronald C. Bernotas, Paul W. Brown, Gary T. Emmons, Chi-Hsin R. King
  • Cyclic nitrones
    Patent number: 5677315
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 14, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas
  • Serotonin 5HT.sub.1A agonistic method
    Patent number: 5559143
    Abstract: The present invention is directed to a new class of serotonin 5HT.sub.1A agonists.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: September 24, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Ronald C. Bernotas, Mark W. Dudley, Jeffrey S. Sprouse
  • Cyclic nitrones
    Patent number: 5532252
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 2, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Cyclic nitrones
    Patent number: 5527812
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 18, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Cyclic nitrones
    Patent number: 5525615
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 11, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Ronald C. Bernotas, Craig E. Thomas
  • Cyclic nitrone compounds useful in treating stroke
    Patent number: 5498778
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: March 12, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Serotonin receptor agents
    Patent number: 5436246
    Abstract: The present invention is directed to a new class of 2-optionally substituted-4-piperazine-benzothiophene derivatives of the formula ##STR1## in which Y is represented by hydrogen or C.sub.1-3 alkyl; R is represented by a substituent selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, --CF.sub.3, --OCF.sub.3, and --OH; R.sub.1 is represented by hydrogen, cycloalkyl, C.sub.1-6 alkyl, phenyl optionally substituted, phenylalkyl, or phenylamidoalkyl; X is represented by hydrogen, --(CH.sub.2).sub.n X.sub.1, CH=CHX.sub.1 or CHX.sub.2 --(CH.sub.2).sub.q --CH.sub.3 ; n is an integer from 0-2; q is either the integer 0 or 1; X.sub.1 is represented by --OH--,--OR.sub.2, --NR.sub.2 R.sub.3, --CO.sub.2 R.sub.2, --CONR.sub.2 R.sub.3, --CN, or --COR.sub.2 ; R.sub.2 and R.sub.3 are each independently represented by hydrogen, C.sub.1-4 alkyl, phenyl optionally substituted, phenylalkyl, or R.sub.2 and R.sub.3 together form a (CH.sub.2).sub.m cycloalkyl, where m=2- 6; X.sub.2 is --OR.
    Type: Grant
    Filed: September 15, 1993
    Date of Patent: July 25, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ronald C. Bernotas, Jeffrey S. Sprouse, Hsien C. Cheng
  • Cyclic nitrones
    Patent number: 5397789
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: March 14, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • 1,4 benzodioxin derivatives and their use as serotonin 5HT.sub.1A agonists
    Patent number: 5387604
    Abstract: The present invention is directed to a new class of serotonin 5HT.sub.1A agonists.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: February 7, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Ronald C. Bernotas, Mark W. Dudley, Jeffrey S. Sprouse
  • Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
    Patent number: 5292746
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Serotonin 5HT.sub.1A agonists
    Patent number: 5189179
    Abstract: The present invention is directed to a new class of serotonin 5HT.sub.1A agonists.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: February 23, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Ronald C. Bernotas, Mark W. Dudley, Jeffrey S. Sprouse