Patents by Inventor Ronald C. D. Breslow

Ronald C. D. Breslow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of steroidal 17.alpha.-arylcarboxylates
    Patent number: 4323512
    Abstract: 17-Arylcarboxylate esters of 9,11-unsubstituted 4-pregnene-17.alpha.,21-diol-3,20-diones are prepared by reaction of the corresponding 17.alpha.-hydroxy derivative with alkyl lithium and an anhydride or acyl halide reagent in the presence of 4-(di-lower alkyl)aminopyridine at low temperatures. A preferred mode of the process is the preparation of 16.beta.-methyl-1,4-pregnadiene-17.alpha.,21-diol3,20-dione 17.alpha.-m-iodobenzoate 21-benzoate, a valuable intermediate in the manufacture of betamethasone.
    Type: Grant
    Filed: May 13, 1981
    Date of Patent: April 6, 1982
    Assignee: Schering Corporation
    Inventors: Ronald C. D. Breslow, Craig S. Wilcox
  • Steroid conversion method and products produced thereby
    Patent number: 4252719
    Abstract: Method for the removal of selected tertiary hydrogen atoms from 5 .alpha.-steroids of the cholestane, androstane and pregnane series by chlorination of 5 .alpha.-steroids esterified with selected iodoaryl substituted esterifying agents which direct a chlorine atom from the chlorinating agent into reactive proximity to the hydrogen atom to be removed.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: February 24, 1981
    Assignee: Research Corporation
    Inventors: Ronald C. D. Breslow, Richard J. Corcoran, Barry B. Snider