Patents by Inventor Ronald C. Griffith
Ronald C. Griffith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7998986Abstract: Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.Type: GrantFiled: December 20, 2002Date of Patent: August 16, 2011Assignee: Exelixis Patent Company LLCInventors: Christopher D. Bayne, Alan T. Johnson, Shao-Po Lu, Raju Mohan, Ronald C. Griffith
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Publication number: 20080247992Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.Type: ApplicationFiled: October 24, 2007Publication date: October 9, 2008Inventors: Christopher D. Roberts, Dong-Fang Shi, Ronald C. Griffith
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Patent number: 7342012Abstract: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating ?L?2 adhesion mediated conditions in a mammal.Type: GrantFiled: March 3, 2005Date of Patent: March 11, 2008Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Ila Sircar, Paul Furth, Bradley R. Teegarden, Marshall Morningstar, Nicholas Smith, Ronald C. Griffith
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Patent number: 7304085Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.Type: GrantFiled: June 4, 2004Date of Patent: December 4, 2007Assignee: Genelabs Technologies, Inc.Inventors: Christopher D. Roberts, Dong-Fang Shi, Ronald C. Griffith
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Patent number: 6897225Abstract: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating ?L?2 adhesion mediated conditions in a mammal.Type: GrantFiled: October 19, 2000Date of Patent: May 24, 2005Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ila Sircar, Marshall Morningstar, Paul Furth, Nicholas Smith, Bradley R. Teegarden, Ronald C. Griffith
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Publication number: 20030181420Abstract: Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.Type: ApplicationFiled: December 20, 2002Publication date: September 25, 2003Inventors: Christopher D. Bayne, Alan T. Johnson, Shao-Po Lu, Raju Mohan, Ronald C. Griffith
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Patent number: 5607935Abstract: Compounds of formula (I), wherein A represents CH.dbd.CH; Q represents pyrazine having substituents R.sup.6 and R.sup.7 ; R.sup.1 represents H or C.sub.1-6 alkyl; R.sup.2 represents H, C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-6 cycloalkyl or NH.sub.2 CH.sub.2 CO--; R.sup.3 represents H, C.sub.1-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-6 alkynyl; R.sup.4 and R.sup.5 independently represent H, OH, C.sub.1-6 alkoxy, C.sub.1-6 alkyl, halogen, trifluoromethyl or NR.sup.8 R.sup.9 ; R.sup.6 and R.sup.7 independently represent H, OH, C.sub.1-6 alkoxy, C.sub.1-6 alkyl, halogen, trifluoromethyl, C.sub.1-6 hydroxyalkyl, amidino, CONH.sub.2 or NR.sup.8 R.sup.9 ; in addition, R.sup.6 and R.sup.7 may independently represent O when substituted on N; R.sup.8 and R.sup.9 independently represent H or C.sub.1-6 alkyl; and pharmaceutically acceptable derivatives thereof. The compounds are useful as pharmaceuticals, in particular in the treatment of neurological disorders.Type: GrantFiled: August 1, 1994Date of Patent: March 4, 1997Assignee: Fisons CorporationInventors: Ronald C. Griffith, Richard J. Schmiesing, Robert J. Griffith
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Patent number: 5605916Abstract: There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano;R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl;R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ;R.sub.3 represents hydrogen or C1 to 6 alkyl;in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl;or a pharmaceutically acceptable salt thereof.Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.Type: GrantFiled: March 6, 1995Date of Patent: February 25, 1997Assignee: Astra ABInventors: Ronald C. Griffith, James J. Napier
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Patent number: 5594000Abstract: Compounds of general formula I, ##STR1## wherein R.sup.1 represents hydrogen or alkyl C.sub.1-3,R.sup.2 represents hydrogen, alkyl C.sub.1-6, alkenyl C.sub.3-6 or alkynyl C.sub.3-6,n and m are integers from 1 to 3, provided that n+m=4, andone of X and Y represents CH.sub.2 and the other represents CHR.sup.3, C=CHR.sup.4 or C=NR.sup.5, in whichR.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16 and R.sup.17 are as defined in the specification,and their saltsare useful as pharmaceuticals, in particular as central muscarinic acetylcholine receptors. The compounds are therefore useful in the treatment of diseases such as presenile and senile dementia, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania and Tourette Syndrome, and also as analgesic agents for use in the treatment of severe painful conditions such as rheumatism, arthritis, and terminal illness.Type: GrantFiled: June 6, 1995Date of Patent: January 14, 1997Assignee: Astra ABInventors: Edwin S.-C. Wu, Ronald C. Griffith
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Patent number: 5539120Abstract: There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano;R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl;R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ;R.sub.3 represents hydrogen or C1 to 6 alkyl;in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl;or a pharmaceutically acceptable salt thereof.Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.Type: GrantFiled: March 6, 1995Date of Patent: July 23, 1996Inventors: Ronald C. Griffith, James J. Napier
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Patent number: 5472968Abstract: Compounds of formula (I), ##STR1## in which R.sub.1 and R.sub.2, which may be the same or different, represent hydrogen, C.sub.1-6 alkyl, R.sub.3 and R.sub.4 independently represent one or more radicals selected from hydrogen, OH, NH.sub.2, NO.sub.2, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy and n is an integer from 1-2 inclusive, and pharmaceutically acceptable derivatives thereof are useful as pharmaceuticals; in particular, they possess N-methyl-(d)-aspartate(NMDA) blocking properties and are useful in the treatment and/or prevention of neurodegenerative conditions.Type: GrantFiled: March 16, 1993Date of Patent: December 5, 1995Assignee: Fisons CorporationInventors: Ronald C. Griffith, James R. Matz, James J. Napier
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Patent number: 5455259Abstract: (S)-.alpha.-phenyl-2-pyridineethanamine, and its pharmaceutically acceptable derivatives, are useful in the treatment of neurodegenerative disorders, and exhibit linear pharmacokinetics.Type: GrantFiled: March 31, 1994Date of Patent: October 3, 1995Assignee: Fisons CorporationInventors: Ronald C. Griffith, Robert J. Murray, Michael Balestra, Donald Mathisen
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Patent number: 5430044Abstract: There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano;R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl;R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ;R.sub.3 represents hydrogen or C1 to 6 alkyl;in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl;or a pharmaceutically acceptable salt thereof.Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.Type: GrantFiled: July 16, 1992Date of Patent: July 4, 1995Assignee: Fisons CorporationInventors: Ronald C. Griffith, James J. Napier
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Patent number: 5382683Abstract: Compounds are provided of the following general structure: ##STR1## wherein B is hydrogen or lower alkyl (C.sub.1 -C.sub.4), R.sub.1 is hydrogen or methyl, R.sub.2 is lower alkyl (C.sub.1 -C.sub.4), phenylmethyl or 2-(aminocarbonyl)ethyl, R.sub.3 is H or lower alkyl (C.sub.1 -C.sub.4) and where W and Q are independently selected from phenyl or 4-fluorophenyl. They are useful for providing sedative and antiepileptic activity.Type: GrantFiled: April 8, 1992Date of Patent: January 17, 1995Assignee: Fisons CorporationInventor: Ronald C. Griffith
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Patent number: 5331007Abstract: There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano;R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl;R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ;R.sub.3 represents hydrogen or C1 to 6 alkyl;in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl;or a pharmaceutically acceptable salt thereof.Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.Type: GrantFiled: July 20, 1992Date of Patent: July 19, 1994Assignee: Fisons CorporationInventors: Ronald C. Griffith, James J. Napier
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Patent number: 5109017Abstract: Compounds of the formula I, ##STR1## in which: R.sub.1 represents hydrogen or C.sub.1-6 alkyl,R.sub.2 represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl or C.sub.3-6 cycloalkyl,R.sub.3 represents one or more radicals selected from hydrogen, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen, trifluoromethyl, amino, lower alkylamino or dilower alkylamino,R.sub.4 represents one or more radicals selected from hydrogen or C.sub.1-6 alkyl,A represents an alpha-amino acid acyl group or an alkoxycarbonyl group,and pharmaceutically acceptable salts thereof are useful as pharmaceuticals, in particular they possess N-methyl-(d)-aspartate (NMDA) blocking properties and are useful in the treatment and/or prevention of neurological disorders such as stroke, cerebral ischaemia, cerebral palsy, hypoglycaemia, epilepsy, Alzheimer's disease, Huntington's chorea, Olivo-ponto-cerebellar atrophy, perinatal asphyxia and anoxia.Type: GrantFiled: September 26, 1990Date of Patent: April 28, 1992Assignee: Fisons CorporationInventors: Richard J. Schmiesing, Ronald C. Griffith, Robert J. Murray
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Patent number: 5093524Abstract: Compounds are provided of the following general structure: ##STR1## wherein R.sub.4 is lower alkyl (C.sub.1 -C.sub.4); R.sub.1 is hydrogen or methyl, R.sub.2 is hydrogen or methyl, R.sub.3 is lower alkyl (C.sub.1 -C.sub.6) or cyclopropyl, and where R.sub.5 and Q are independently selected from phenyl or 4-fluorophenyl. They are useful for providing sedative and antiepileptic activity.Type: GrantFiled: October 15, 1990Date of Patent: March 3, 1992Assignee: Fisons CorporationInventor: Ronald C. Griffith
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Patent number: 5075317Abstract: Compounds of general formula I, ##STR1## wherein R.sup.1 represents hydrogen or alkyl C.sub.1-3,R.sup.2 represents hydrogen or alkyl C.sub.1-6,n and m are integers from 1 to 3, provided that n+m=4, andone of X and Y represents CH.sub.2 and the other represents CHR.sup.3, C.dbd.O, C.dbd.CHR.sup.4 or C.dbd.NR.sup.5, in whichR.sup.3, R.sup.4 and R.sup.5 are as defined in the specification,and their saltsare useful as pharmaceuticals, in particular as central muscarinic acetylcholine receptors. The compounds are therefore useful in the treatment of diseases such as presenile and senile dementia, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania and Tourette Syndrome, and also as analgesic agents for use in the treatment of severe painful conditions such as rheumatism, arthritis, and terminal illness.Type: GrantFiled: June 21, 1989Date of Patent: December 24, 1991Assignee: Fisons CorporationInventors: Edwin S. Wu, Ronald C. Griffith
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Patent number: 5047541Abstract: Compounds are provided of the following general structure: ##STR1## wherein A is 2-pyrrolidinyl, 2-piperidinyl or 4-thiazolidinyl and R and R.sub.1 are independently selected from hydrogen and methyl. They are useful for providing sedative and antiepileptic activity.Type: GrantFiled: June 14, 1989Date of Patent: September 10, 1991Assignee: Fisons CorporationInventor: Ronald C. Griffith
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Patent number: 4912222Abstract: 4-Dibenzocycloheptenyl, 4-dibenzocycloheptyl, and 4-dibenzoxepinylpiperidine compounds possessing antihistaminic activity.Type: GrantFiled: June 17, 1988Date of Patent: March 27, 1990Assignee: Fisons CorporationInventors: Ronald C. Griffith, James J. Napier