Patents by Inventor Ronald C. Orlando

Ronald C. Orlando has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isotopically labeled glycans and methods for producing the same
    Patent number: 10078081
    Abstract: The present invention relates to methods for creating isotopically-labeled glycans or glycoconjugates for use in the analysis of glycans, and compositions produced from such methods. The present invention also relates to the use of isotopically labeled glycans or glycoconjugates as standards in glycan identification and/or quantification methods. In one embodiment, the method of the present invention can be used to accurately determine the levels of glycans in a sample based upon the addition of a known quantity of a standard comprising isotopically-labeled glycans to the sample prior to analysis. In one embodiment, the present invention relates to a composition for an analytical standard comprising one or more isotopically-labeled glycans or glycoconjugates.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: September 18, 2018
    Assignee: GlycoScientific LLC
    Inventors: Barry Edward Boyes, Ronald C. Orlando
  • Vivo isotopic labeling method for quantitative glycomics
    Patent number: 9329169
    Abstract: The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: May 3, 2016
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC
    Inventors: Robert Lance Wells, Ronald C. Orlando, Stephen Dalton, Kelley W. Moremen, James Michael Pierce, James A. Atwood, III, Michael Tiemeyer, William S. York
  • Isotopically Labeled Glycans and Methods for Producing the Same
    Publication number: 20150253332
    Abstract: The present invention relates to methods for creating isotopically-labeled glycans or glycoconjugates for use in the analysis of glycans, and compositions produced from such methods. The present invention also relates to the use of isotopically labeled glycans or glycoconjugates as standards in glycan identification and/or quantification methods. In one embodiment, the method of the present invention can be used to accurately determine the levels of glycans in a sample based upon the addition of a known quantity of a standard comprising isotopically-labeled glycans to the sample prior to analysis. In one embodiment, the present invention relates to a composition for an analytical standard comprising one or more isotopically-labeled glycans or glycoconjugates.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 10, 2015
    Inventors: Barry Edward Boyes, Ronald C. Orlando
  • VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS
    Publication number: 20100297609
    Abstract: The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
    Type: Application
    Filed: October 29, 2008
    Publication date: November 25, 2010
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Robert Lance Wells, Ronald C. Orlando, Stephen Dalton, Kelley W. Moreman, Michael J. Pierce, James A. Attwood, III, Michael Tiemeyer, William S. York