Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: The invention relates to inhibitory nucleic acids targeting the ataxin-2 gene (ATXN2), and expression cassettes and vectors comprising the same. Also provided herein are methods of treating neurodegenerative diseases, e.g., Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia-2.

Abstract: An operating current modifying device is provided for a power generating element. The power generating element generates an output power when the operating current is larger than a threshold current in the power generating element. A functional relationship is between the threshold current and the temperature of the electrical device. The operating current modifying device includes a threshold current modifying module, a power modifying module, a current compensating module, and a power control module. The threshold current modifying module receives a temperature signal from the power generating element to output a threshold current modifying signal according to the temperature signal and the functional relationship. The power modifying module receives a power feedback signal from the power generating element and a target power signal to output an operating current modifying signal.

Abstract: A power control device of multi base powers is provided for an optical read/write module of an optical disk drive. The optical read/write module generates a power feedback signal and a temperature signal. The power control device includes a base power selecting module, a current compensating module, a current computing module and a current integrating module. The base power selecting module selects one of a first base power signal and a second base power signal to output a base power signal. The current compensating module generates an operating current compensating signal and a threshold compensating signal according to the power feedback signal, the temperature signal, the base power signal and a function relationship between the temperature signal and the threshold current of the optical read/write module.

Abstract: A threshold current modifying device is provided for an optical pickup head. The optical pickup head initially generates an output power when an operating current is larger than a threshold current of the optical pickup head, and the threshold current is related to a temperature of the optical pickup head in a functional relationship. The threshold current modifying device includes a threshold current calculating module and a power control module. The threshold current calculating module receives a temperature signal from the optical pickup head at a first temperature to output a threshold current signal according to the temperature signal and the functional relationship. The power control module receives the threshold current signal to adjust the operating current.

Abstract: A power control device of single base power is provided for an optical read/write module of an optical disk drive. The optical read/write module generates a power feedback signal and a temperature signal. The power control device includes a current compensating module, a current computing module and a current integrating module. The current compensating module generates an operating current compensating signal and a threshold compensating signal according to the power feedback signal, the temperature signal, a base power signal and a function relationship between the temperature signal and the threshold current of the optical read/write module. The current computing module receives the operating current compensating signal to compute a first operating current signal and a second operating current signal based on the operating current compensating signal according to the base power signal and a reference power signal.

Abstract: An operating current modifying device is provided for a power generating element. The power generating element generates an output power when the operating current is larger than a threshold current in the power generating element. A functional relationship is between the threshold current and the temperature of the electrical device. The operating current modifying device includes a threshold current modifying module, a power modifying module, a current compensating module, and a power control module. The threshold current modifying module receives a temperature signal from the power generating element to output a threshold current modifying signal according to the temperature signal and the functional relationship. The power modifying module receives a power feedback signal from the power generating element and a target power signal to output an operating current modifying signal.

Abstract: A power control method is provided for an optical disk drive. The optical disk drive has an optical read/write module for accessing an optical storage media. The power control method includes the following steps: measuring the temperature of the optical read/write module; predicting a threshold current of the optical read/write module according to the temperature; determine the accessing mode of the optical storage media; measuring the output power of the optical read/write module; computing a first current required for the optical read/write module according to the output power of the optical read/write module and a base power in the accessing mode; compensating the computed first current according to the predicted threshold current; and driving the optical read/write module according to the first current.

Abstract: An operating current modifying device is provided for a power generating element. The power generating element generates an output power when the operating current is larger than a threshold current in the power generating element. A functional relationship exists between the threshold current and the temperature of the electrical device. The operating current modifying device may include a threshold current modifying module, a power modifying module, a current compensating module, and a power control module.

Abstract: A power control device of multi base powers is provided for an optical read/write module of an optical disk drive. The optical read/write module generates a power feedback signal and a temperature signal. The power control device includes a base power selecting module, a current compensating module, a current computing module and a current integrating module. The base power selecting module selects one of a first base power signal and a second base power signal to output a base power signal. The current compensating module generates an operating current compensating signal and a threshold compensating signal according to the power feedback signal, the temperature signal, the base power signal and a function relationship between the temperature signal and the threshold current of the optical read/write module.

Abstract: A power control device of single base power is provided for an optical read/write module of an optical disk drive. The optical read/write module generates a power feedback signal and a temperature signal. The power control device includes a current compensating module, a current computing module and a current integrating module. The current compensating module generates an operating current compensating signal and a threshold compensating signal according to the power feedback signal, the temperature signal, a base power signal and a function relationship between the temperature signal and the threshold current of the optical read/write module. The current computing module receives the operating current compensating signal to compute a first operating current signal and a second operating current signal based on the operating current compensating signal according to the base power signal and a reference power signal.

Abstract: An operating current modifying device is provided for a power generating element. The power generating element generates an output power when the operating current is larger than a threshold current in the power generating element. A functional relationship is between the threshold current and the temperature of the electrical device. The operating current modifying device includes a threshold current modifying module, a power modifying module, a current compensating module, and a power control module. The threshold current modifying module receives a temperature signal from the power generating element to output a threshold current modifying signal according to the temperature signal and the functional relationship. The power modifying module receives a power feedback signal from the power generating element and a target power signal to output an operating current modifying signal.

Abstract: A threshold current modifying device is provided for an optical pickup head. The optical pickup head initially generates an output power when an operating current is larger than a threshold current of the optical pickup head, and the threshold current is related to a temperature of the optical pickup head in a function relationship. The threshold current modifying device includes a threshold current calculating module and a power control module. The threshold current calculating module receives a temperature signal from the optical pickup head at a first temperature to output a threshold current signal according to the temperature signal and the function relationship. The power control module receives the threshold current signal to adjust the operating current.

Abstract: A power control device of single base power is provided for an optical read/write module of an optical disk drive. The optical read/write module generates a power feedback signal and a temperature signal. The power control device includes a current compensating module, a current computing module and a current integrating module. The current compensating module generates an operating current compensating signal and a threshold compensating signal according to the power feedback signal, the temperature signal, a base power signal and a function relationship between the temperature signal and the threshold current of the optical read/write module. The current computing module receives the operating current compensating signal to compute a first operating current signal and a second operating current signal based on the operating current compensating signal according to the base power signal and a reference power signal.

Abstract: A power control device of single base power is provided for an optical read/write module of an optical disk drive. The optical read/write module generates a power feedback signal and a temperature signal. The power control device includes a current compensating module, a current computing module and a current integrating module. The current compensating module generates an operating current compensating signal and a threshold compensating signal according to the power feedback signal, the temperature signal, a base power signal and a function relationship between the temperature signal and the threshold current of the optical read/write module. The current computing module receives the operating current compensating signal to compute a first operating current signal and a second operating current signal based on the operating current compensating signal according to the base power signal and a reference power signal.

Abstract: A power control method is provided for an optical disk drive. The optical disk drive has an optical read/write module for accessing an optical storage media. The power control method includes the following steps: measuring the temperature of the optical read/write module; predicting a threshold current of the optical read/write module according to the temperature; determine the accessing mode of the optical storage media; measuring the output power of the optical read/write module; computing a first current required for the optical read/write module according to the output power of the optical read/write module and a base power in the accessing mode; compensating the computed first current according to the predicted threshold current; and driving the optical read/write module according to the first current.