Abstract: Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an Fc?R, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino acid e.g. Gln, Asn, Glu, or Asp. also provided are corresponding polypeptides, nucleic acids, and methods of use of the same e.g. in improved lytic therapies.

Abstract: The invention provides methods for designing contact lenses and contact lenses designed according to the method, which lenses provide an improved method for presbyopia correction compared to conventional lenses and methods. It is a discovery of the invention that improved performance and reduced design time can be obtained by using lens pairs that act synergistically to provide the lens wearer with good binocularity and consistent performance in near, intermediate and distance vision.

Abstract: Disclosed are binding molecules which are recombinant polypeptides containing: (i) a binding domain capable of binding a target molecule, and (ii) an effector domain having an amino acid sequence substantially homologous to all or part of a constant domain of a human immunoglobulin heavy chain; characterized in that the binding molecule is capable of binding the target molecule without triggering significant complement dependent lysis, or cell mediated destruction of the target, and more preferably wherein the effector domain is capable of specifically binding FcRn and/or Fc?RIIb. These are generally based on chimeric domains which are derived from two or more human immunoglobulin heavy chain CH2 domains domains. In preferred embodiments the regions 233-236, and 327-331, are modified, as are further residues to render the molecule null allotypic. Also disclosed are nucleic acids, host cells, production processes and materials, and uses. Pharmaceutical preparations are also disclosed.

Abstract: The invention provides methods for designing contact lenses and contact lenses designed according to the method, which lenses provide an improved method for presbyopia correction compared to conventional lenses and methods. It is a discovery of the invention that improved performance and reduced design time can be obtained by using lens pairs that act synergistically to provide the lens wearer with good binocularity and consistent performance in near, intermediate and distance vision.

Abstract: Digital Subscriber Line (DSL) concentrating systems and other equipment from various manufacturers may be tracked and monitored with a single DSL tracking tool. The DSL tracking tool functions as part of a system of computing devices and databases with various user interfaces. The DSL tracking tool can perform analyses and generate reports about DSL devices, DSL sites, DSL concentrating systems, and routers to aid service providers in provisioning and maintaining DSL equipment.

Abstract: A light weight, flexible, strong, sound reducing, insulation increasing R Factor, water-resistant, dent resistant wall and ceiling enclosure product that installs and finishes identical to drywall. My invention doesn't require deforestation and mining pollution.

Abstract: An electric heating device that generates its own power supply. When air current travels through ventilation duct systems; the air turns an air current driven generator, which produces electricity to energize its heating elements. The heat generator case provides heat or additional hair to a space.

Abstract: A Sexual Stimulated Apparatus attached to A Rubber handle Exercise Ball that is mounted..

Abstract: An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species. An antibody which is capable of binding to human CD4 antigen is also provided together with a pharmaceutical composition comprising the antibody.

Abstract: A photovoltaic (PV) cell device comprises a first semiconductor substrate; a second semiconductor substrate bonded to the first semiconductor substrate; an insulating layer provided between the first and second substrates to electrically isolate the first substrate from the second substrate; a plurality of PV cells defined on the first substrate, each PV cell including a n-type region and a p-type region; a plurality of vertical trenches provided in the first substrate to separated the PV cells, the vertical trenches terminating at the insulating layer; a plurality of isolation structures provided within the vertical trenches, each isolation structure including a first isolation layer including oxide and a second isolation layer including polysilicon; and an interconnect layer patterned to connect the PV cells to provide X number of PV cells in series and Y number of PV cells in parallel.