Patents by Inventor Ronald D. Klein

Ronald D. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Soluble, active recombinant human MAO-B
    Publication number: 20020164744
    Abstract: Monoamine oxidase B is an integral polypeptide of the outer mitochondrial membrane. Purified, soluble, biologically active human MAO-B is obtained by recombinant methods in amounts useful for high volume screening.
    Type: Application
    Filed: April 12, 2002
    Publication date: November 7, 2002
    Inventors: Martin R. Deibel, Ronald D. Klein, Anthony W. Yem
  • Pichia pastoris linear plasmids and DNA fragments thereof
    Patent number: 5665600
    Abstract: Two novel linear DNA plasmids are described. Also, novel fragments of the plasmids containing the autonomous replication sequence (ARS), and thus capable of self-maintenance as extra chromosomal elements are provided. These novel DNA sequences of the present invention are useful in a vector for self-maintenance in Pichia pastoris and are also useful as plasmid vectors which can be shuttled between yeast and bacteria.
    Type: Grant
    Filed: September 18, 1991
    Date of Patent: September 9, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Mary Jane Hagenson, Kathryn A. Barr, David W. Stroman, Frank H. Gaertner, Michael M. Harpold, Ronald D. Klein
  • Method of indentifying compounds useful as antiparasitic drugs
    Patent number: 5079143
    Abstract: A method for identifying compounds useful as antiparasitic drugs is disclosed. Deficient microorganisms are complemented with homologous metabolic enzyme genes. The metabolic enzyme is the drug target. In addition, recombinant DNA molecules comprising helminthic PFK and PEPCK genes are disclosed.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: January 7, 1992
    Assignee: The Upjohn Company
    Inventors: Ronald D. Klein, Timothy G. Geary
  • High volume nutrient based yeast two-hybrid assay for the identification of specific protein:protein interacting inhibitors
    Patent number: H1892
    Abstract: This invention describes how to make and use several effective high volume screens for the discovery of inhibitors of specific protein:protein interactions, using aspects of the yeast two-hybrid system.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: October 3, 2000
    Assignee: Pharmacia and Upjohn Company
    Inventors: Ronald D. Klein, Jerry M. Buysse