Patents by Inventor Ronald D. Macfarlane

Ronald D. Macfarlane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170108465
    Abstract: The claimed invention is directed to a system and method for the detection of biomarkers in disease using various methods of analysis to identify biomarkers involved either directly or indirectly in health and disease by comparing the electrophoresis profiles from the biofluid of diseased and healthy individuals.
    Type: Application
    Filed: October 17, 2016
    Publication date: April 20, 2017
    Inventors: Ronald D. Macfarlane, Katharine G. Wigginton
  • Publication number: 20140193846
    Abstract: Novel isoforms of apolipoprotein C-I (apoC-I), namely apolipoprotein C-I1 (apoC-I1) and apolipoprotein C-I1? (apoC-I1?), both of which have a molecular weight of approximately 90 daltons greater than native apolipoprotein C-I (SEQ ID NO:6) and native apolipoprotein C-I? (SEQ ID NO:7), are shown to be both biomarkers for diagnosing atherosclerotic disease as well as risk factors for subjects having increased risk of developing an atherosclerotic disease.
    Type: Application
    Filed: December 23, 2011
    Publication date: July 10, 2014
    Applicants: SCOTT & WHITE HEALTHCARE, THE JOHNS HOPKINS UNIVERSITY, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Ronald D. Macfarlane, Catherine J. McNeal, Subroto Chatterjee
  • Publication number: 20110178718
    Abstract: A method of characterizing a biological sample comprising separating the biological sample into constituents; observing the separated constituents; applying statistical classification modeling to the observed constituents; deriving quantifiable data from the applied statistical classification modeling; and analyzing the data from the applied statistical classification modeling to assess a donor of the biological compounds' health.
    Type: Application
    Filed: December 13, 2010
    Publication date: July 21, 2011
    Applicants: Scott and White Memorial Hospital and Scott, Sherwood, and Brindley Foundation, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Ronald R. Henriquez, Jeffery D. Johnson, Simon Sheather, Ronald D. MacFarlane, Catherine J. McNeal, Craig D. Larner
  • Patent number: 7320893
    Abstract: Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized, resulting in a lipoprotein profile. The fractions can be further analyzed by a wide array of laboratory and clinical methods. The lipoprotein profile can be used in clinical diagnoses and other medical applications.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: January 22, 2008
    Assignee: The Texas A&M University System
    Inventors: Ronald D Macfarlane, Brian D Hosken, Zachlyn N Farwig, Irma L Espinosa, Christine L Myers, Steven L Cockrill
  • Publication number: 20040171078
    Abstract: Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized, resulting in a lipoprotein profile. The fractions can be further analyzed by a wide array of laboratory and clinical methods. The lipoprotein profile can be used in clinical diagnoses and other medical applications.
    Type: Application
    Filed: March 8, 2004
    Publication date: September 2, 2004
    Inventors: Ronald D. MacFarlane, Brian D. Hosken, Zachlyn N. Farwig, Irma L. Espinosa, Christine L. Myers, Steven L. Cockrill
  • Patent number: 6753185
    Abstract: Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized, resulting in a lipoprotein profile. The fractions can be further analyzed by a wide array of laboratory and clinical methods. The lipoprotein profile can be used in clinical diagnoses and other medical applications.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: June 22, 2004
    Assignee: The Texas A&M University System
    Inventors: Ronald D. Macfarlane, Brian D. Hosken, Zachlyn N. Farwig, Irma L. Espinosa, Christine L. Myers, Steven L. Cockrill
  • Patent number: 6593145
    Abstract: Methods of forming a density gradient by applying a centrifugal field to a solution of one or more metal ion chelate complexes are disclosed. The density gradients are self-forming equilibrium gradients and are useful for separating biological particles by ultracentrifugation. Also disclosed are methods of separating biological particles according to their density. Also disclosed are density gradients of lipoprotein particles and one or more metal ion chelate complexes, wherein the lipoprotein particles are partitioned along the density gradient according to their particle density.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: July 15, 2003
    Assignee: The Texas A&M University System
    Inventors: Ronald D. Macfarlane, Brian D. Hosken
  • Publication number: 20030087310
    Abstract: Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized, resulting in a lipoprotein profile. The fractions can be further analyzed by a wide array of laboratory and clinical methods. The lipoprotein profile can be used in clinical diagnoses and other medical applications.
    Type: Application
    Filed: October 1, 2002
    Publication date: May 8, 2003
    Inventors: Ronald D. Macfarlane, Brian D. Hosken, Zachlyn N. Farwig, Irma L. Espinosa, Christine L. Myers, Steven L. Cockrill
  • Publication number: 20020166815
    Abstract: Methods of forming a density gradient by applying a centrifugal field to a solution of one or more metal ion chelate complexes are disclosed. The density gradients are self-forming equilibrium gradients and are useful for separating biological particles by ultracentrifugation. Also disclosed are methods of separating biological particles according to their density. Also disclosed are density gradients of lipoprotein particles and one or more metal ion chelate complexes, wherein the lipoprotein particles are partitioned along the density gradient according to their particle density.
    Type: Application
    Filed: March 6, 2002
    Publication date: November 14, 2002
    Inventors: Ronald D. Macfarlane, Brian D. Hosken