Patents by Inventor Ronald D. Seidel, III

Ronald D. Seidel, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20190062400
    Abstract: The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
    Type: Application
    Filed: March 1, 2017
    Publication date: February 28, 2019
    Inventors: Ronald D. Seidel, III, Rodolfo Chaparro
  • T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20190046648
    Abstract: The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
    Type: Application
    Filed: March 2, 2017
    Publication date: February 14, 2019
    Inventors: Ronald D. Seidel, III, Rodolfo Chaparro
  • SYNTAC POLYPEPTIDES AND USES THEREOF
    Publication number: 20180282392
    Abstract: Methods and compositions for clonally inhibiting or clonally stimulating T-cells are provided.
    Type: Application
    Filed: June 6, 2018
    Publication date: October 4, 2018
    Applicant: Albert Einstein College of Medicine, Inc
    Inventors: Ronald D. Seidel, III, Rodolfo J. Chaparro, Brandan S. Hillerich, Scott J. Garforth, Steven C. Almo
  • Methods for high throughput receptor:ligand identification
    Patent number: 10048271
    Abstract: Methods and systems for high-throughput identification of receptor:ligand interactions are provided.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: August 14, 2018
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Steven C. Almo, Ronald D. Seidel, III, Brandan S. Hillerich, Sarah C. Garrett-Thomson, James D. Love
  • SYNTAC POLYPEPTIDES AND USES THEREOF
    Publication number: 20170058015
    Abstract: Methods and compositions for clonally inhibiting or clonally stimulating T-cells are provided.
    Type: Application
    Filed: June 15, 2015
    Publication date: March 2, 2017
    Inventors: Ronald D. Seidel, III, Rodolfo J. Chaparro, Brandan S. Hillerich, Scott J. Garforth, Steven C. Almo
  • METHODS FOR HIGH THROUGHPUT RECEPTOR:LIGAND IDENTIFICATION
    Publication number: 20160011204
    Abstract: Methods and systems for high-throughput identification of receptor:ligand interactions are provided.
    Type: Application
    Filed: December 5, 2013
    Publication date: January 14, 2016
    Inventors: Steven C. Almo, Ronald D. Seidel, III, Brandan S. Hillerich, Sarah C. Garrett-Thomson, James D. Love