Abstract: A heating, ventilation, and air conditioning system in which a primary water loop is used as a heat transfer reservoir for both heating and cooling. A plurality of micro chillers are provided, with each micro chiller being connected to the primary water loop. Each micro chiller includes its own heat engine. Each micro chiller includes one or more fan coil units that exchange heat between the micro chiller and the air in a building. In a first mode a micro chiller transfers heat from the air in the building to the water circulating within the primary water loop. In a second mode the micro chiller transfers heat from the water circulating in the primary water loop to the air in the building. A primary water loop regulation system is provided to control the temperature of the water circulating in the primary water loop.

Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

Abstract: An extraction device, including a motor, a driveshaft operatively coupled to the motor and driven to rotate thereby, a punch tool directly coupled to a distal end of the driveshaft to rotate therewith, and arranged to be in physical contact with a skin layer during operation of the extraction device, a force sensor operatively coupled to the driveshaft to measure a force exerted thereupon by the skin layer, and a controller communicatively coupled to the motor and to the force sensor. The controller is configured to define multiple rotary modes and multiple multiphasic modes, each multiphasic mode including at least two rotary modes, receive a selection of a multiphasic mode, and provide, based on the selection, a control signal to the motor instructing the motor to operate in the multiphasic mode.

Abstract: A dispenser for a volatile liquid composition includes a housing; a reservoir holding the liquid composition; a transport member for the liquid composition; and an evaporative member in fluid communication with the transport member. The evaporative member includes a wickable mesh. A method for dispensing a volatile liquid composition using a dispenser includes the step of wetting the evaporative member with the liquid composition; and evaporating the composition from the evaporative member.

Abstract: An object bundling apparatus includes an opening defining an engagement channel having an inner wall. At least one body engagement member is disposed on the inner wall having a holding surface laterally bound by a first end and a second end. The holding surface has a non-linear surface profile between the first end and second end. A strap is adapted to be passed through the opening in a direction of insertion, the strap having a plurality of strap engagement members. Each of the strap engagement members includes a contact surface laterally bound by a first strap end and a second strap end. The contact surface has a non-linear surface profile between the first strap end and second strap end. The non-linear contact surface profile of the strap is configured to nest within the non-linear holding surface profile upon advancement of the strap in a direction opposite the direction of insertion.

Abstract: A heating, ventilation, and air conditioning system in which a primary water loop is used as a heat transfer reservoir for both heating and cooling. A plurality of micro chillers are provided, with each micro chiller being connected to the primary water loop. Each micro chiller includes its own heat engine. Each micro chiller includes one or more fan coil units that exchange heat between the micro chiller and the air in a building. In a first mode a micro chiller transfers heat from the air in the building to the water circulating within the primary water loop. In a second mode the micro chiller transfers heat from the water circulating in the primary water loop to the air in the building. A primary water loop regulation system is provided to control the temperature of the water circulating in the primary water loop.

Abstract: An ophthalmic device includes a lens and an electronic component embedded in the lens to enhance the functionality of the lens. The ophthalmic device includes a first coil to wirelessly receive energy from an external device, such as a wireless charger, and wirelessly transmits the received energy to a second coil coupled to the electronic component so as to power the electronic component. The first coil can function as part of a repeater to facilitate the wireless charging. The repeater can receive electrical energy wirelessly and works with various positions, sizes, and shapes of the electronic component. The wireless power efficiency can also be increased using the repeater to concentrate a magnetic flux within the second coil.

Abstract: A digital transaction ledger with a DNA-related parameter is provided by obtaining DNA-based data unique to a particular entity, and establishing a DNA-related ledger parameter using the DNA-based data. Further, the method includes associating the DNA-based ledger parameter with a digital transaction ledger, making the digital transaction ledger related, at least in part, to the obtained DNA-based data.

Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

Abstract: Methods, systems, and kits for estimating fetal fraction in a mixed fetal-maternal DNA sample are disclosed, by molecular counting of a predetermined set of informative sequences. These find use in detecting and quantifying variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, in the context of non-invasive prenatal testing.

Abstract: A uterine fibroid tissue removal device includes an inner tube disposed within an outer tube and configured to be translated and rotated relative to the outer tube, and a separately formed unitary distal tip member attached to a distal end of the inner tube, such that the distal tip member translates and rotates relative to the outer tube along with the inner tube, wherein a distal facing open cutting end of the distal tip member in fluid communication with an axial lumen of the distal tip member translates across a tissue resection window in a sidewall of the outer tube so as to sever tissue extending therethrough, the distal tip member axial lumen being in fluid communication with an axial lumen of the inner tube, wherein an outer diameter of the distal tip member is greater than an outer diameter of the inner tube.

Abstract: Aspects herein are directed to a vented lower-body garment that includes a plurality of panels that extend at least partially across a back aspect of a first leg portion and a second leg portion, around a medial aspect of the first leg portion and a second leg portion, and at least partially across a front aspect of first leg portion and a second leg portion. Respective edges of the panels overlap each other to form vent openings that facilitate the flow of air into and out of the garment.

Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

Abstract: A volatile composition dispenser and a method of dispensing a volatile composition is provided. The volatile composition dispenser includes a reservoir for containing a volatile composition and a transport member having a first end portion and an opposing second end portion, and an evaporative surface. The first end portion of the transport member is in fluid communication with the reservoir and the second end portion of the transport member is in fluid communication with the evaporative surface. The volatile composition dispenser also includes an air pump in gaseous communication with the reservoir.

Abstract: A multi-stage compressor where the refrigerant is transferred from stage to stage internally. The compressor uses a first stage impeller mounted on a first end of motor shaft and a second stage impeller mounted on a second end of the same motor shaft. The motor shaft and both impellers rotate in unison. Refrigerant discharged from the first stage impeller is transferred to the intake of the second state impeller through passages within the compressor itself.

Abstract: A uterine fibroid tissue removal device includes an inner tube disposed within an outer tube and configured to be translated and rotated relative to the outer tube, and a separately formed unitary distal tip member attached to a distal end of the inner tube, such that the distal tip member translates and rotates relative to the outer tube along with the inner tube, wherein a distal facing open cutting end of the distal tip member in fluid communication with an axial lumen of the distal tip member translates across a tissue resection window in a sidewall of the outer tube so as to sever tissue extending therethrough, the distal tip member axial lumen being in fluid communication with an axial lumen of the inner tube, wherein an outer diameter of the distal tip member is greater than an outer diameter of the inner tube.

Abstract: A cable bundling system is disclosed. The cable bundling system includes a base having an opening extending through the base; a barb supported by the base and extending at least partially across the opening; and a strap adapted to be advanced through the opening in a first direction. When the strap is displaced in a second direction opposite the first direction, the barb pierces a medial portion of the strap such that the barb contacts the base. The strap can include a longitudinal groove extending a length of the strap, and the barb has a piercing portion opposite a supported portion. The piercing portion can pierce the medial portion of the strap.

Abstract: Aspects herein are directed to a vented upper-body garment that includes a plurality of panels that extend across a back aspect of a torso region of the garment, around first and second sides of the torso region, and at least partially across a front aspect of the torso region. Respective edges of the panels overlap each other to form vent openings that facilitate the flow of air into and out of the garment.

Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

Abstract: The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.