Abstract: A fluid control and processing system comprising a cartridge and an instrument for operating the cartridge. The cartridge comprises a cylinder body comprising a cylinder and a fluid port. It further comprises dispensing ports to drive a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with at least a fluid port by rotation of the cylinder body. The instrument comprises a piston driver for driving the piston. The system further comprises: reversible fastening means for fastening the piston when the piston driver is rotated with respect to the piston, so that the movement of the piston is controlled by the piston driver; and rotating means comprising a cylinder driver constitutive of the instrument for rotating the cylinder body around the axis A.

Abstract: Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part.

Abstract: Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.

Abstract: A manifold system is provided that includes a manifold housing and a manifold core. The manifold housing is configured to receive the manifold core. The manifold housing includes an oblique inner surface and at least one fluidic channel. The fluidic channel ends with one of its ends at the oblique inner surface. The manifold housing together with the at least one fluidic channel has no undercut.

Abstract: A fluid control and processing system comprising a cartridge and an instrument for operating the cartridge. The cartridge comprises a cylinder body comprising a cylinder and a fluid port. It further comprises dispensing ports to drive a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with at least a fluid port by rotation of the cylinder body. The instrument comprises a piston driver for driving the piston. The system further comprises: reversible fastening means for fastening the piston when the piston driver is rotated with respect to the piston, so that the movement of the piston is controlled by the piston driver; and rotating means comprising a cylinder driver constitutive of the instrument for rotating the cylinder body around the axis A.

Abstract: An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.

Abstract: The present invention relates to a sealing device for closing an introduction aperture, the sealing device comprising a fixed support and a shutter mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means for guiding the movement of the shutter and designed so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.

Abstract: The present invention relates to a sealing device for closing an introduction aperture, the sealing device comprising a fixed support and a shutter mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means for guiding the movement of the shutter and designed so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.

Abstract: A method for irradiating a sample with focused acoustic energy is provided. The generated acoustic energy is transmitted from the source to the sample via a completely dry propagation path. At least two different focal regions are generated with the source for generating acoustic energy.

Abstract: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Abstract: A device for treating a sample with focused acoustic energy is provided. The device transmits the generated acoustic energy from the source to the sample via a complete dry propagation path. A cartridge containing the sample is inserted into an instrument, wherein the insertion forms a dry propagation path.

Abstract: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Abstract: A manifold system is provided that includes a manifold housing and a manifold core. The manifold housing is configured to receive the manifold core. The manifold housing includes an oblique inner surface and at least one fluidic channel. The fluidic channel ends with one of its ends at the oblique inner surface. The manifold housing together with the at least one fluidic channel has no undercut.

Abstract: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Abstract: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Abstract: An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.

Abstract: Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.