Abstract: The disclosure provides an expression vector (e.g., AAV vector) comprising a nucleic acid sequence encoding (1) the heavy and/or light chain of an antibody and (2) one or more shRNA sequences targeting fucosyltransferase-8 (FUT8).

Abstract: Compositions are provided comprising a replication-competent herpesvirus vector system and/or a herpesvirus vector particle comprising a heterologous recombinant transgene of interest encoding an antigen of interest (e.g., a tumor-associated antigen, a microbial antigen, etc.), wherein the recombinant transgene has been modified to comprise a codon usage signature of a herpesvirus late gene operably linked to an active promoter. Such compositions find use in a variety of methods including, for example, methods of generating an immune response against an antigen of interest in a subject in need thereof, as well as methods for treating or preventing cancer or a microbial infection.

Abstract: Compositions are provided comprising a replication-competent herpesvirus vector system and/or a herpesvirus vector particle comprising a heterologous recombinant transgene of interest encoding an antigen of interest (e.g., a tumor-associated antigen, a microbial antigen, etc.), wherein the recombinant transgene has been modified to comprise a codon usage signature of a herpesvirus late gene operably linked to an active promoter. Such compositions find use in a variety of methods including, for example, methods of generating an immune response against an antigen of interest in a subject in need thereof, as well as methods for treating or preventing cancer or a microbial infection.

Abstract: A twin-belt casting machine for casting metal strip. The machine is provided with a casting cavity which includes an upstream fixed casting region, in which the belts are in fixed convergent paths in contact with the cast slab, and an adjacent downstream portion in which the belts are adjustable between alignment with the fixed convergent paths and non-alignment therewith (being less convergent or divergent). When the adjustable portions of the paths are moved outwardly relative to the fixed convergent paths, the belts separate from the cast slab at differing predetermined points within the casting cavity. By adjusting the downstream portion of the casting cavity in this manner, the casting machine can operate at essentially constant throughput for a wide range of alloys while ensuring that the cast slab exiting the caster has a temperature within a predetermined range suitable for further rolling to produce sheet product.

Abstract: A casting belt for using in a single-belt or twin-belt casting apparatus is disclosed. The casting belt is made of aluminum alloy such as an alloy from the AA5XXX and AA6XXX systems, preferably having a thickness in the range of 1 to 2 mm. The aluminum casting belt of the invention is suitable for casting non-ferrous and light metals such as aluminum, magnesium, copper, zinc and their alloys, especially aluminum alloys such as Al—Mg, Al—Mg—Si, Al—Fe—Si and Al—Fe—Mn—Si alloy systems. A belt casting machine and process using the aluminum casting belt of the invention are also disclosed.

Abstract: A continuous belt casting apparatus is provided with a casting cavity, and at least one flexible metal belt having an elongated casting surface passing through and at least partially defining the casting cavity. A motor is provided for rotating the metal belt in the longitudinal direction of the casting surface whereby the casting surface passes through the casting cavity in the longitudinal direction. A molten metal supply device delivers molten metal continuously to the casting cavity, so that molten metal supplied to the casting cavity is solidified and removed as a continuous strip ingot from the casting cavity by rotation of the belt. The casting surface is provided with a plurality of grooves oriented in substantially the same direction. The invention also relates to a casting belt for such an apparatus and a method of casting using the apparatus.