Patents by Inventor Ronald Doll

Ronald Doll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds that are ERK inhibitors
    Patent number: 7807672
    Abstract: Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substituents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: October 5, 2010
    Assignee: Schering Corporation
    Inventors: Yongqi Deng, Gerald W. Shipps, Jr., Alan Cooper, Yang Nan, Tong Wang, M. Arshad Siddiqui, Hugh Zhu, Robert Sun, Joseph M. Kelly, Ronald Doll, Jagdish Desai, James J-S Wang, Youhao Dong, Vincent Madison, Li Xiao, Alan Hruza, Neng-Yang Shih
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20080050384
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: April 20, 2007
    Publication date: February 28, 2008
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Alan Mallams, Carmen Alvarez, Kartik Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry Fischmann, Lawrence Dillard, Vinh Tran, Zhenmin He, Ray James, Haengsoon Park, Vidyadhar Paradkar, Douglas Hobbs, Paul Kirschmeier, Rajat Bannerji
  • 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES
    Publication number: 20080004248
    Abstract: In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17?-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17?-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: August 9, 2007
    Publication date: January 3, 2008
    Inventors: Timothy Guzi, Yi-Tsung Liu, Ronald Doll, Anil Saksena, Viyyoor Girijavallabhan, Jonathan Pachter
  • Substituted Piperidines that Increase P53 Activity and the Uses Thereof
    Publication number: 20080004287
    Abstract: In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 3, 2008
    Inventors: Yao Ma, Brian Lahue, Gerald Shipps, Yaolin Wang, Stephane Bogen, Matthew Voss, Latha Nair, Yuan Tian, Ronald Doll, Zhuyan Guo, Corey Strickland, Rumin Zhang, Mark McCoy, Weidong Pan, Elise Siegel, Craig Gibeau
  • NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS
    Publication number: 20070275983
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: July 17, 2007
    Publication date: November 29, 2007
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Lawrence Dillard, Vinh Tran, Zhenmin He, Ray James, Haengsoon Park
  • PYRAZOLO[1,5-a]PYRIMIDINES
    Publication number: 20070275963
    Abstract: In its many embodiments, the present invention provides certain pyrazolo[1,5-a]pyrimidine compounds which can have utility as inhibitors of cyclin dependent kinases as well as methods of preparing such compounds. The compounds can have potential utility for the treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 29, 2007
    Inventors: Timothy Guzi, Ronald Doll, Amin Nomeir
  • Novel compounds that are ERK inhibitors
    Publication number: 20070232610
    Abstract: Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 4, 2007
    Inventors: Yongqi Deng, Gerald Shipps, Alan Cooper, Yang Nan, Tong Wang, M. Siddiqui, Hugh Zhu, Robert Sun, Joseph Kelly, Ronald Doll, Jagdish Desai, James Wang, Youhao Dong, Vincent Madison, Li Xiao, Alan Hruza, Neng-Yang Shih
  • Novel compounds that are ERK inhibitors
    Publication number: 20070191604
    Abstract: Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
    Type: Application
    Filed: December 11, 2006
    Publication date: August 16, 2007
    Inventors: Alan Cooper, Yongqi Deng, Gerald Shipps, Neng-Yang Shih, Hugh Zhu, Robert Sun, Joseph Kelly, Ronald Doll, Yang Nan, Tong Wang, Jagdish Desai, James Wang, Youhao Dong, Vincent Madison, Li Xiao, Alan Hruza, M. Siddiqui, Ahmed Samatar, Sunil Paliwal, Hon-Chung Tsui, Azim Celebi, Yiji Wu, Sobhana Boga
  • NOVEL IMIDAZOPYRAZINES AS CYCLIN DEPENDENT KINASE INHIBITORS
    Publication number: 20070155751
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Inventors: KAMIL PARUCH, Timothy Guzi, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20070054906
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: March 8, 2007
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Alan Mallams, Carmen Alvarez, Kartik Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry Fischmann, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park, Vidyadhar Paradkar, Douglas Hobbs
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20070054925
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: March 8, 2007
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Alan Mallams, Carmen Alvarez, Kartik Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry Fischmann, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park, Vidyadhar Paradkar, Douglas Hobbs
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20070037824
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 3, 2003
    Publication date: February 15, 2007
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Alan Mallams, Carmen Alvarez, Kartik Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry Fischmann, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park, Vidyadhar Paradkar, Douglas Hobbs
  • Compounds for inhibiting KSP kinesin activity
    Publication number: 20060258699
    Abstract: The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
    Type: Application
    Filed: March 7, 2006
    Publication date: November 16, 2006
    Inventors: Ronald Doll, Ronald Herbst, Wolfgang Seghezzi, Emma Lees, William Estacio
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20060235025
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: October 19, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20060178371
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: August 10, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Carmen Alvarez, Tin-Yau Chan, Chad Knutson, Vincent Madison, Thierry Fischmann, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20060173016
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: August 3, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park
  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20060173017
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: August 3, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Chad Knutson, Brian McKittrick, Lawrence Dillard, Vinh Tran, Zhen Min He, Ray James, Haengsoon Park
  • Adjustable rotating shaft guard
    Publication number: 20060144201
    Abstract: A rotating shaft guard assembly includes a first guard portion, a second guard portion and an end cap. A rectilinear portion defines a generally flat leg receipt area to mount a leg selected from one of a multitude of legs. The end cap is mountable to a semi-cylindrical guard portion in a press-fit manner. The end cap includes a stepped pyramid end which provide a shaft exit of a predetermined diameter by cutting off the circular steps which are smaller than the desired shaft diameter exit.
    Type: Application
    Filed: January 6, 2005
    Publication date: July 6, 2006
    Inventor: Ronald Doll
  • 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Publication number: 20060142338
    Abstract: In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17?-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17?-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: February 23, 2006
    Publication date: June 29, 2006
    Inventors: Timothy Guzi, Yi-Tsung Liu, Ronald Doll, Anil Saksena, Viyyoor Girijavallabhan, Jonathan Pachter
  • 17 Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Publication number: 20060069103
    Abstract: There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17?-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.
    Type: Application
    Filed: November 14, 2005
    Publication date: March 30, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Alan Mallams, Jocelyn Rivera, Ronald Doll, Viyyoor Girijavallabhan, Jonathan Pachter, Yi-Tsung Liu, Anil Saksena