Patents by Inventor Ronald E. Betts

Ronald E. Betts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and Methods for Treating Viral and Other Medical Conditions
    Publication number: 20240100025
    Abstract: This application relates generally to the field of drug treatment paradigms based on specifically formulated compounds for use in targeted therapy or disease prevention. Specifically, this technology provides for compositions and methods for treating, stabilizing, preventing or delaying disease conditions related to viral infections and other inflammatory conditions.
    Type: Application
    Filed: December 10, 2021
    Publication date: March 28, 2024
    Inventor: Ronald E. Betts
  • Intratumoral drug delivery materials and methods for treating breast cancer
    Patent number: 11826492
    Abstract: Generally, the invention is in relation to the field of drug delivery devices to augment standard radiation therapy and methods of making and using same. Specifically, this technology utilizes a controlled release of drug from a coated balloon for local intratumoral drug delivery to breast tissue to supplement or replace standard radiation therapy.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 28, 2023
    Assignee: BIOTRONIK AG
    Inventor: Ronald E. Betts
  • INTRACRANIAL DRUG DELIVERY MATERIALS AND METHODS
    Publication number: 20230364016
    Abstract: This application relates generally to the field of minimally invasive delivery of therapeutic agents. Specifically, the present invention provides for materials and methods directed to minimally invasive, targeted delivery of agents such as drugs, penetrants, blood barrier augmentation agents or other compounds to certain localized brain regions through the use of delivery balloon catheters.
    Type: Application
    Filed: July 17, 2023
    Publication date: November 16, 2023
    Inventor: Ronald E Betts
  • MICROSPHERE DRUG COATED MEDICAL DEVICES, MATERIALS AND METHODS
    Publication number: 20230293780
    Abstract: The field of materials and manufacturing methods involving single or multi-solvent, excipient and polymer-free drug coating formulations for production of microsphere coated drug delivery techniques.
    Type: Application
    Filed: July 28, 2021
    Publication date: September 21, 2023
    Inventors: Ronald E. Betts, Ana Jhelynne P. Nagui, John Dang Nguyen, David Quach
  • Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods
    Patent number: 11383009
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: July 12, 2022
    Assignee: Biotronik AG
    Inventors: Ronald E. Betts, John Dang Nguyen, Beatris Flores
  • Covered Stent For Local Drug Delivery
    Publication number: 20220088278
    Abstract: The present invention relates generally to an endoprosthesis for maintaining patency of a body vessel, e.g., a stent, in a basically tubular configuration comprised of a structural lattice with a mesh covering which is capable of storing releasing one or more drugs to and penetrating into surrounding tissue.
    Type: Application
    Filed: January 28, 2020
    Publication date: March 24, 2022
    Inventors: Ronald E. Betts, Douglas R. Savage
  • INTRACRANIAL DRUG DELIVERY MATERIALS AND METHODS
    Publication number: 20210186872
    Abstract: This application relates generally to the field of minimally invasive delivery of therapeutic agents. Specifically, the present invention provides for materials and methods directed to minimally invasive, targeted delivery of agents such as drugs, penetrants, blood barrier augmentation agents or other compounds to certain localized brain regions through the use of delivery balloon catheters.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 24, 2021
    Inventor: Ronald E Betts
  • PARENTERAL FORMULATION MATERIALS AND METHODS FOR 40-O-CYCLIC HYDROCARBON ESTERS AND RELATED STRUCTURES
    Publication number: 20200397763
    Abstract: This application relates generally to the field of drug treatment paradigms based on specifically formulated compounds for use in targeted therapy or disease prevention. Specifically, this technology provides for compositions and methods for treating, stabilizing, preventing or delaying disease conditions through administration of highly lipophilic compositions with a globular serum protein in combination with other pharmaceutical compositions.
    Type: Application
    Filed: January 29, 2019
    Publication date: December 24, 2020
    Inventor: Ronald E Betts
  • Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
    Publication number: 20200345902
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Inventors: Ronald E. Betts, John Dang Nguyen, Beatris Flores
  • Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods
    Patent number: 10751450
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: August 25, 2020
    Assignee: Biotronik AG
    Inventors: Ronald E. Betts, John Dang Nguyen, Beatris Flores
  • Intratumoral Drug Delivery Materials and Methods for Treating Breast Cancer
    Publication number: 20200030498
    Abstract: Generally, the invention is in relation to the field of drug delivery devices to augment standard radiation therapy and methods of making and using same. Specifically, this technology utilizes a controlled release of drug from a coated balloon for local intratumoral drug delivery to breast tissue to supplement or replace standard radiation therapy.
    Type: Application
    Filed: December 19, 2017
    Publication date: January 30, 2020
    Inventor: Ronald E. Betts
  • Polymer-Free Drug Eluting Vascular Stents
    Publication number: 20190388210
    Abstract: This application relates generally to the field of implants and more specifically to drug eluting vascular stents and methods of making and using same. Specifically, this technology relates to controlled release of drug from an implant and particular from a stent without the presence of polymer or alteration of the implant surface.
    Type: Application
    Filed: September 19, 2017
    Publication date: December 26, 2019
    Inventor: Ronald E. Betts
  • Drug releasing coatings for medical devices and methods of making same
    Publication number: 20190358369
    Abstract: Generally, the invention is in relation to the field of drug releasing insertable devices and methods of making and using same. Specifically, this technology relates to controlled release of drug from a coated balloon directly into affected tissue regions within the body of an individual.
    Type: Application
    Filed: December 19, 2017
    Publication date: November 28, 2019
    Inventors: Ronald E. Betts, John Dang Nguyen
  • Drug delivery endovascular stent and method of use
    Patent number: 10456508
    Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: October 29, 2019
    Assignee: Biosensors International Group, Ltd.
    Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
  • Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
    Publication number: 20190290810
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Application
    Filed: March 20, 2019
    Publication date: September 26, 2019
    Inventors: Ronald E. Betts, John Dang Nguyen, Beatris Flores
  • Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
    Publication number: 20180078683
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 22, 2018
    Inventors: Ronald E. Betts, John Dang Nguyen
  • Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods
    Patent number: 9867911
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n-X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: January 16, 2018
    Assignee: Biotronik AG
    Inventors: Ronald E. Betts, John Dang Nguyen
  • DRUG DELIVERY ENDOVASCULAR STENT AND METHOD OF USE
    Publication number: 20170128635
    Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
    Type: Application
    Filed: January 13, 2017
    Publication date: May 11, 2017
    Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
  • Drug delivery endovascular stent and method of use
    Patent number: 9579424
    Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 28, 2017
    Assignee: Biosensors International Group, Ltd.
    Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
  • Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
    Publication number: 20170021065
    Abstract: A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n-X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
    Type: Application
    Filed: July 18, 2016
    Publication date: January 26, 2017
    Inventors: Ronald E. Betts, John Dang Nguyen