Patents by Inventor Ronald E. Viola

Ronald E. Viola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anat Inhibitors and Methods of Use Thereof
    Publication number: 20230128972
    Abstract: Inhibitors of a critical brain enzyme, N-acetyltransferase (ANAT), and methods of discovering, making and using the same for the treatment of disease are disclosed.
    Type: Application
    Filed: January 29, 2021
    Publication date: April 27, 2023
    Inventors: Ronald E. Viola, Adrian Stecula
  • Potent inhibitors of aspartate N-acetyl-transferase for the treatment of Canavan disease
    Patent number: 11186541
    Abstract: Compounds, compositions, and methods for the treatment of Canavan disease are described.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 30, 2021
    Assignee: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang
  • POTENT INHIBITORS OF ASPARTATE N-ACETYL-TRANSFERASE FOR THE TREATMENT OF CANAVAN DISEASE
    Publication number: 20200270202
    Abstract: Compounds, compositions, and methods for the treatment of Canavan disease are described.
    Type: Application
    Filed: March 23, 2017
    Publication date: August 27, 2020
    Applicant: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang
  • Potent phthalate inhibitors of aspartate N-acetyltransferase and selective aspartate pathway inhibitors
    Patent number: 10449168
    Abstract: Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as methods of making the same, and methods of using the same.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: October 22, 2019
    Assignee: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang, Pravin Bhansali
  • PURIFICATION OF A SOLUBLE AND ACTIVE FORM OF ASPARTATE N-ACETYLTRANSFERASE
    Publication number: 20180340156
    Abstract: Fusion proteins that include N-acetylaspartate synthetase (ANAT) and at least one solubilizing partner, such as glutathione 5-transferase (GST), thioredoxin (TRX), or maltose binding protein (MBP), are described. Also described are methods of making the fusion proteins, methods of solubilizing the fusion proteins, methods of purifying the fusion proteins, and methods of using the fusion proteins.
    Type: Application
    Filed: September 8, 2016
    Publication date: November 29, 2018
    Applicant: The University of Toledo
    Inventors: Ronald E. Viola, Qinzhe Wang, Mojun Zhao, Gwenn Parungao
  • POTENT PHTHALATE INHIBITORS OF ASPARTATE N-ACETYLTRANSFERASE AND SELECTIVE ASPARTATE PATHWAY INHIBITORS
    Publication number: 20180250252
    Abstract: Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as methods of making the same, and methods of using the same.
    Type: Application
    Filed: August 29, 2016
    Publication date: September 6, 2018
    Applicant: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang, Pravin Bhansali
  • Truncated aspartase enzyme derivatives and uses thereof
    Patent number: 6133013
    Abstract: Truncated derivatives of aspartase having enhanced catalytic activity and/or enhanced clot dissolution properties relative to native aspartase from E. coli. The enzymes are isolated by site-directed mutagenesis of DNA encoding aspartase. L-aspartic acid is manufactured by contacting fumarate and ammonium ion in the presence of an aspartase derivative.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 17, 2000
    Assignee: The University of Akron
    Inventors: Ronald E. Viola, Maithri M. K. Jayasekera, Abdullah S. Saribas
  • Truncated aspartase enzyme derivatives and uses thereof
    Patent number: 5993807
    Abstract: Truncated derivatives of aspartase having enhanced catalytic activity and/or enhanced clot dissolution properties relative to native aspartase from E. coli. The enzymes are isolated by site-directed mutagenesis of DNA encoding aspartase. L-aspartic acid is manufactured by contacting fumarate and ammonium ion in the presence of an aspartase derivative.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: November 30, 1999
    Assignee: The University of Akron
    Inventors: Ronald E. Viola, Maithri M. K. Jayasekera, Abdullah S. Saribas