Abstract: The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the benzoic acid derivative of Formula 3: and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding a sample suspected of containing procainamide to said solution; adding an anti-procainamide antibody to said solution and observing the rate of increase in solution turbidity following antibody addition.

Abstract: A method for manufacturing a turbine nozzle assembly using a fixture includes providing a first position of the fixture, positioning at least one datum of the turbine nozzle assembly adjacent at least one datum location point on the fixture when the fixture is in the first position, coupling the turbine nozzle assembly to the fixture when the fixture is in the first position, rotating the fixture from the first position into a second position that facilitates manufacturing the turbine nozzle assembly, and performing a manufacturing process on the turbine nozzle assembly when the fixture is in the second position.

Abstract: A method for removably holding an electrode for use in an electric-discharge machining (EDM) apparatus including a tool holder having an expandable collet. The method includes providing the collet in an unclamped position, receiving at least a portion of the electrode within an opening of the collet, and moving the collet to a clamped position using at least one of electrical, pneumatic, and hydraulic power, wherein in the clamped position the collet exerts a radially inward force around a circumference of the electrode to facilitate fixedly holding the electrode.

Abstract: Lidocaine analogs, latex particle-analog conjugates, and methods of making and using the same. The analogs have the formula: wherein Z comprises a nucleophilic group and optionally a protecting group; L is a linker; R1, R2, R3, R4, R5 are each independently H, a protecting group, or C1 to C6 alkyls, provided that R1 and R3 may form a six membered ring with the nitrogen and carbon atom to which R1 and R3 are attached; R6 and R7 are each independently H or C1 to C20 alkyls; and including salts thereof. The analogs are immobilized on latex particles and prepared for use in assays for lidocaine.

Abstract: The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the benzoic acid derivative of Formula 3: and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding a sample suspected of containing procainamide to said solution; adding an anti-procainamide antibody to said solution and observing the rate of increase in solution turbidity following antibody addition.

Abstract: An apparatus comprising a valve body having first, second and vent ports and a generally tubular valve element having a peripheral wall with first, second and vent openings in the peripheral wall leading to the interior of the tubular valve element. The valve element is mounted in the valve body for rotational movement between first and second rotational positions and for axial movement between first and second axial positions. A pressure sensor is exposed to the fluid pressure within the valve body. In the first rotational position of the valve element, drip flow is provided between the first and second ports, and in the second rotational position, the vent port is open to provide communication between the pressure sensor and the atmosphere. To provide flush flow between the first and second ports, the valve element is moved to the second axial position.

Abstract: A piezoresistive differential pressure transducer in which the need for convoluted isolating diaphragms and oil fill is eliminated. The instrument as contemplated by the invention does not require O-ring seals or springs to provide over-pressure protection. The absence of convoluted diaphragms and oil minimizes inherent errors due to temperature variations and static line pressure effect.