Patents by Inventor Ronald F. Ofstead
Ronald F. Ofstead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8202833Abstract: The present invention provides method and materials for forming a polymeric matrix having improved biocompatible properties. A polymerization accelerator is provided that includes an N-vinyl group and a biocompatible functional group. The polymerization accelerator is particularly useful for the polymerization of macromers, which can be used to form biocompatible polymeric coatings on the surface of biological materials, such as cells and tissue.Type: GrantFiled: November 26, 2003Date of Patent: June 19, 2012Assignee: Surmodics, Inc.Inventors: Dale G. Swan, Stephen J. Chudzik, Ronald F. Ofstead
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Patent number: 8143043Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: GrantFiled: April 2, 2009Date of Patent: March 27, 2012Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Patent number: 8129159Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: September 9, 2010Date of Patent: March 6, 2012Assignee: Surmodics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Publication number: 20110054417Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: November 8, 2010Publication date: March 3, 2011Applicant: SurModics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Publication number: 20110009292Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: ApplicationFiled: September 9, 2010Publication date: January 13, 2011Applicant: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Patent number: 7833548Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: August 19, 2005Date of Patent: November 16, 2010Assignee: Surmodics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Patent number: 7829317Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: September 14, 2007Date of Patent: November 9, 2010Assignee: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Publication number: 20100158799Abstract: A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: March 3, 2010Publication date: June 24, 2010Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
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Publication number: 20090317887Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: ApplicationFiled: April 2, 2009Publication date: December 24, 2009Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Patent number: 7585499Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: GrantFiled: April 10, 2003Date of Patent: September 8, 2009Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Publication number: 20090042742Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: ApplicationFiled: September 14, 2007Publication date: February 12, 2009Applicant: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Patent number: 7309593Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: October 1, 2003Date of Patent: December 18, 2007Assignee: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Publication number: 20070248637Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: August 19, 2005Publication date: October 25, 2007Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Patent number: 7097850Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: June 18, 2002Date of Patent: August 29, 2006Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Publication number: 20040202774Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: ApplicationFiled: April 10, 2003Publication date: October 14, 2004Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Publication number: 20030232122Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 18, 2003Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Publication number: 20030232087Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 18, 2003Inventors: Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
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Publication number: 20020188037Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 12, 2002Inventors: Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
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Patent number: 5188688Abstract: A gelatin capsule sealant of a water soluble, amide-containing polymer adhesive in a volatile, essentially non-aqueous solvent is used to seal gelatin capsule sections together at less than the entire circumference of overlap between the capsule sections. The sealant may also adhere a pharmaceutical caplet within the capsule to the internal wall of the capsule. The method of applying the sealant to the capsule sections and possibly also the pharmaceutical caplet uses a drop of the sealant spread at the junction of an eccentric arcuate portion of the sections and the pharmaceutical caplet. The solvent evaporates from the sealant through the portion of the capsule section overlap not sealed. The sealant may use "generally regarded as safe" (GRAS) solvents and may also include a GRAS dye for visual indication tha that the capsule is eccentrically sealed to resist manually forced separation of the capsule sections.Type: GrantFiled: July 20, 1990Date of Patent: February 23, 1993Assignee: Minnesota Mining and Manufacturing CompanyInventors: James R. Boardman, Ronald F. Ofstead
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Patent number: 4977901Abstract: A non-crosslinked crystallized polymer or polymer blending coating is disclosed for articles that come into contact with bodily fluids. The polymer or polymer blend to be used is crystallizable and is stable in the presence of water at temperatures of up to about 60.degree. C. when in the crystalline state. The polymer or polymer blend is dissolved in a solvent, such as water or dimethyl sulfoxide (DMSO), and is coated on the article. The polymer coating is then crystallized, generally by heat treatment, providing both toughness and increased adherence of the coating to the article without ready dissolution when the article comes into contact with fluids.Type: GrantFiled: April 6, 1990Date of Patent: December 18, 1990Assignee: Minnesota Mining and Manufacturing CompanyInventor: Ronald F. Ofstead