Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: System and method configured to determine a direction of movement of a vehicle in response to a brake being released or in response to initiating movement of the vehicle from a stopped position along a route. The direction of movement is determined based on a selected travel direction of the vehicle, a grade of the route, and at least one of applied tractive efforts or applied braking efforts.

Abstract: A vehicle control system determines an upper non-zero limit on deceleration of a vehicle to prevent rollback of the vehicle down a grade being traveled up on by the vehicle. The upper non-zero limit on deceleration is determined by the controller based on a payload carried by the vehicle, a speed of the vehicle, and a grade of a route being traveled upon by the vehicle. The controller is configured to monitor the deceleration of the vehicle, and to automatically prevent the deceleration of the vehicle from exceeding the upper non-zero limit by controlling one or more of a brake or a motor of the vehicle. The controller also is configured to one or more of actuate the brake or supply current to the motor of the vehicle to prevent rollback of the vehicle while the vehicle is moving up the grade at a non-zero speed.

Abstract: System and method configured to determine a direction of movement of a vehicle in response to a brake being released or in response to initiating movement of the vehicle from a stopped position along a route. The direction of movement is determined based on a selected travel direction of the vehicle, a grade of the route, and at least one of applied tractive efforts or applied braking efforts.

Abstract: A vehicle control system determines an upper non-zero limit on deceleration of a vehicle to prevent rollback of the vehicle down a grade being traveled up on by the vehicle. The upper non-zero limit on deceleration is determined by the controller based on a payload carried by the vehicle, a speed of the vehicle, and a grade of a route being traveled upon by the vehicle. The controller is configured to monitor the deceleration of the vehicle, and to automatically prevent the deceleration of the vehicle from exceeding the upper non-zero limit by controlling one or more of a brake or a motor of the vehicle. The controller also is configured to one or more of actuate the brake or supply current to the motor of the vehicle to prevent rollback of the vehicle while the vehicle is moving up the grade at a non-zero speed.

Abstract: A wheel guide rail for lateral delimitation of a washing area of a vehicle treatment installation has an elongated housing and several light modules distributed along the housing. The housing has several openings distributed over its length. Each light module includes a mounting base mounted in one of the openings of housing and at least one light source mounted in the mounting base.

Abstract: A vehicle treatment facility, in particular a gantry washing facility, includes at least one outer body formed as a vertical pillar and in which at least one operating unit is housed or can be housed. The outer body includes at least one pull-out, by which the at least one operating unit is movable in translation between a closed position, in which the operating unit is housed in the outer body, and an opened position, in which the operating unit is at least partially accessible from outside.

Abstract: A vehicle control system determines an upper non-zero limit on deceleration of a vehicle to prevent rollback of the vehicle down a grade being traveled up on by the vehicle. The upper non-zero limit on deceleration is determined by the controller based on a payload carried by the vehicle, a speed of the vehicle, and a grade of a route being traveled upon by the vehicle. The controller is configured to monitor the deceleration of the vehicle, and to automatically prevent the deceleration of the vehicle from exceeding the upper non-zero limit by controlling one or more of a brake or a motor of the vehicle. The controller also is configured to one or more of actuate the brake or supply current to the motor of the vehicle to prevent rollback of the vehicle while the vehicle is moving up the grade at a non-zero speed.

Abstract: This disclosure describes a method for accessing network resources which includes receiving by a first application in a mobile computing device sign-in information from a user and enabling the user to sign in to a second application with the first application to access network resources from a resource server based on (a) a first application identification (ID) of the second application, (b) the user authorizing the second application to the resource server, and (c) receiving an authorization grant from the resource server to enable the second application to access the network resources, the mobile computing device coupled with the resource server via a network.

Abstract: A wheel guide rail for lateral delimitation of a washing area of a vehicle treatment installation has an elongated housing and several light modules distributed along the housing. The housing has several openings distributed over its length. Each light module includes a mounting base mounted in one of the openings of housing and at least one light source mounted in the mounting base.

Abstract: Methods and systems are provided for synchronizing and sharing a file. A set of access privileges is configured within a cloud collaboration site to define a sharing configuration to allow sharing of the file between a group of computing devices comprising a first computing device and one or more second computing devices. A sync client automatically creates a sync folder on the first computing device that is used for storing files added to the sync folder. When a file is updated at the first computing device and added to the sync folder, the updated file is automatically synchronized at the cloud collaboration site so that the updates are accessible by the one or more second computing devices. The updated file is automatically pushed from the cloud collaboration site to the one or more second computing devices to share the updated file in accordance with the sharing configuration.

Abstract: Subject viewpoint data and external viewpoint data are collected, such as via cameras, and separate virtual or synthetic video views are generated, one from the subject viewpoint and one from an external viewpoint. The subject video view is presented to the subject, such as via a headset, while the external video view is presented to at least one other person. At least the subject video view is presented sufficiently close in time to permit the subject to react to it. A model is referenced so the video views may include a virtual or synthetic setting, or at least partial replacement of the subject with a character, or both.

Abstract: Methods and systems are provided for synchronizing and sharing a file. A set of access privileges is configured within a cloud collaboration site to define a sharing configuration to allow sharing of the file between a group of computing devices comprising a first computing device and one or more second computing devices. A sync client automatically creates a sync folder on the first computing device that is used for storing files added to the sync folder. When a file is updated at the first computing device and added to the sync folder, the updated file is automatically synchronized at the cloud collaboration site so that the updates are accessible by the one or more second computing devices. The updated file is automatically pushed from the cloud collaboration site to the one or more second computing devices to share the updated file in accordance with the sharing configuration.

Abstract: A vehicle control system determines an upper non-zero limit on deceleration of a vehicle to prevent rollback of the vehicle down a grade being traveled up on by the vehicle. The upper non-zero limit on deceleration is determined by the controller based on a payload carried by the vehicle, a speed of the vehicle, and a grade of a route being traveled upon by the vehicle. The controller is configured to monitor the deceleration of the vehicle, and to automatically prevent the deceleration of the vehicle from exceeding the upper non-zero limit by controlling one or more of a brake or a motor of the vehicle. The controller also is configured to one or more of actuate the brake or supply current to the motor of the vehicle to prevent rollback of the vehicle while the vehicle is moving up the grade at a non-zero speed.

Abstract: Methods and systems are provided for synchronizing and sharing data objects. The method includes configuring a set of access privileges, within a collaboration site, to define a sharing configuration to allow sharing of a set of data objects between a group of computing devices comprising a first computing device and second computing devices; updating a data object at the first computing device; receiving an updated data object at the collaboration site from a sync client of the first computing device in response to saving the updated data object; automatically synchronizing the updated data object at the collaboration site; and automatically pushing the updated data object from the collaboration site to the second computing devices to share the updated data object in accordance with the sharing configuration.

Abstract: Methods and systems are provided for synchronizing and sharing data objects. The method includes configuring a set of permissions, within a collaboration site, to define a sharing configuration to allow sharing of a set of data objects between a group of computing devices comprising a first computing device and second computing devices; updating a data object at the first computing device; receiving an updated data object at the collaboration site from a sync client of the first computing device in response to saving the updated data object; automatically synchronizing the updated data object at the collaboration site; and automatically pushing the updated data object from the collaboration site to the second computing devices to share the updated data object in accordance with the sharing configuration.

Abstract: Methods and systems are provided for synchronizing and sharing data objects in a cloud based social networking environment of the type including a collaboration cloud. The method includes defining a sharing configuration based on at least one metadata key word, within the collaboration cloud, the sharing configuration including a second computing device; running a dedicated client synchronization application on a first computing device; updating a data object using the first computing device; automatically synchronizing the updated data object with the collaboration cloud; and propagating, using the collaboration cloud, the updated data object to the second computing device.

Abstract: A computer-implemented digital steganography method includes providing a plurality of target data elements each comprising a sequence of digital bits, providing a plurality of source data elements each comprising a sequence of digital bits and has a specific start bit, and generating, according to a predefined extraction method, a mapping of each of the target data elements with a corresponding source data element. The mapping includes, for each target data element, a corresponding indice indicating the position of the specific start bit within a bitwise representation of the source data elements irrespective of the bitwise position of each of the source data elements.

Abstract: This disclosure describes a method for accessing network resources which includes receiving by a first application in a mobile computing device sign-in information from a user and enabling the user to sign in to a second application with the first application to access network resources from a resource server based on (a) a first application identification (ID) of the second application, (b) the user authorizing the second application to the resource server, and (c) receiving an authorization grant from the resource server to enable the second application to access the network resources, the mobile computing device coupled with the resource server via a network.