Patents by Inventor Ronald Frank Jacobus De Winter

Ronald Frank Jacobus De Winter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specific binding reagent comprising a variable domain protein linked to a support or tracer
    Patent number: 6274324
    Abstract: Small specific binding molecules, such as single variable domain antibodies (Dabs) and Fv fragments, can be coupled to solid plastics surfaces or to tracers such as enzymes by means of linkers comprising polypeptides containing from 5 to 20 amino acids and which are hydrophobic and/or contain at least one lysine residue. The coupling can be achieved without significant loss of specific binding activity. The combined Dab/linker or Fv/linker can be prepared by expression in genetically-modified organisms.
    Type: Grant
    Filed: April 12, 1994
    Date of Patent: August 14, 2001
    Assignee: Unilever Patent Holdings B.V.
    Inventors: Paul James Davis, Martine Elisa Verhoeyen, Ronald Frank Jacobus De Winter