Patents by Inventor Ronald G. Schultz

Ronald G. Schultz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
    Patent number: 5599922
    Abstract: Modified oligonucleotide 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more stable duplexes than phosphodiesters with complementary DNA and particularly RNA strands. Further, the phosphoramidate analogs can also form stable triplexes with double-stranded DNA target, where under similar conditions parent phosphodiester compounds failed to do so.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: February 4, 1997
    Assignee: Lynx Therapeutics, Inc.
    Inventors: Sergei M. Gryaznov, Ronald G. Schultz, Jer-kang Chen
  • Oligonucleotide N3.fwdarw.P5' phosphoramidates: triplex DNA formation
    Patent number: 5591607
    Abstract: Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more stable duplexes than phosphodiesters with complementary DNA and particularly RNA strands. Further, the phosphoramidate analogs can also form stable triplexes with double-stranded DNA target, where under similar conditions parent phosphodiester compounds failed to do so.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 7, 1997
    Assignee: Lynx Therapeutics, Inc.
    Inventors: Sergei M. Gryaznov, Ronald G. Schultz, Jer-kang Chen
  • Railway hopper car closure actuating mechanism
    Patent number: 4224877
    Abstract: An apparatus for pivoting and locking a door on the bottom of a rail hopper car includes a locking mechanism for locking the door when closed and a lever mechanism for pivoting the door between closed and open positions. The locking mechanism and lever mechanism are separate but are operated by a single sliding operating linkage on the bottom of the car.
    Type: Grant
    Filed: May 26, 1978
    Date of Patent: September 30, 1980
    Assignee: Pullman Incorporated
    Inventors: Marvin Stark, Ronald G. Schultz, Robert A. Spychalski