Patents by Inventor Ronald G. Sommer
Ronald G. Sommer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7858758Abstract: Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.Type: GrantFiled: June 24, 2008Date of Patent: December 28, 2010Assignee: Siemens Healthcare Diagnostics, Inc.Inventors: Michael J. Pugia, Linda Anderson-Mauser, Solomon H. Murphy, Ronald G. Sommer, Shannon Gleason
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Publication number: 20090041627Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.Type: ApplicationFiled: September 8, 2008Publication date: February 12, 2009Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, James A. Profitt, Ronald G. Sommer, Sung-Kwon Jung
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Publication number: 20080312420Abstract: Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.Type: ApplicationFiled: June 24, 2008Publication date: December 18, 2008Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, Linda Anderson-Mauser, Solomon H. Murphy, Ronald G. Sommer, Shannon Gleason
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Patent number: 7435381Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.Type: GrantFiled: May 29, 2003Date of Patent: October 14, 2008Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, James A. Profitt, Ronald G. Sommer, Sung-Kwon Jung
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Patent number: 7419665Abstract: Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.Type: GrantFiled: July 29, 2004Date of Patent: September 2, 2008Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, Linda Anderson-Mauser, Solomon H. Murphy, Ronald G. Sommer, Shannon Gleason
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Publication number: 20040241042Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.Type: ApplicationFiled: May 29, 2003Publication date: December 2, 2004Inventors: Michael J. Pugia, James A. Profitt, Ronald G. Sommer, Sung-Kwon Jung
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Patent number: 6404972Abstract: An optical fiber (1) has an outer coating (4) enclosing the cladding (3) and the fiber core (2). The coating has one or more plastic layers and a color coding in the form of an annular marking on or in the outermost plastic layer. The annular marking is open colored rings.Type: GrantFiled: July 17, 2000Date of Patent: June 11, 2002Assignee: AlcatelInventors: Jürgen Pasch, Hans-Jürgen Lysson, Wilhelm Reiners, Bertram Glessner, Ronald G. Sommer
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Patent number: 5750411Abstract: Disclosed is a method for determining the concentration of an analyte in a liquid test sample. The method involves the use of colloidal sized metal particles, which exhibit a spectral response in the agglomerated state which is detectably different than in their unagglomerated state, which bear specific binding partners for the analyte in question on their surface. The specific binding partner treated colloidal particles are combined in a buffered, aqueous medium with a destabilizer material capable of destabilizing the specific binding partner-colloidal particle conjugates thereby permitting the particles to agglomerate. Also included in the liquid medium is a polymer bearing multiple analyte or analyte analog molecules along its surface which serves to protect the specific binding partner coated metal particles from dissociation by the destabilizing agent.Type: GrantFiled: June 3, 1996Date of Patent: May 12, 1998Assignee: Bayer CorporationInventor: Ronald G. Sommer
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Patent number: 5569608Abstract: A method for determining the concentration of analyte in a test fluid by immunochromatography techniques which involves quantitatively determining the signals from captured analyte/labeled binding partner complex by an instrument, e.g. reflectance spectrometer. In a preferred embodiment, a reflectance reading is determined for the captured complex and uncomplexed labeled binding partner which is captured in a separate zone of the immunochromatographic strip and the ratio of these reflectances is used to provide additional quantitation to the assay method.Type: GrantFiled: January 30, 1995Date of Patent: October 29, 1996Assignee: Bayer CorporationInventor: Ronald G. Sommer
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Patent number: 5424215Abstract: The detection of protein is accomplished using novel composition and method involving phenolsulfonephthalein protein error indicator, buffer and an aliphatic ether-polycarbonate present in an amount equal to or less than ten percent by weight.Type: GrantFiled: February 7, 1994Date of Patent: June 13, 1995Assignee: Miles Inc.Inventors: James P. Albarella, Angela A. Michaels, Michael J. Pugia, Ronald G. Sommer
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Patent number: 5326707Abstract: A composition, test device and method of determining the presence or concentration of proteins, such as albumin, in a liquid test sample, such as urine. The test device includes a test pad with a carrier matrix incorporating a indicator reagent composition capable of interacting with proteins to produce a detectable response. The indicator reagent composition includes an indicator dye that is capable of interacting with albumin and undergoing a detectable color transition; a buffer; a hydrophobic polymeric compound having the general structural formula: ##STR1## wherein A is ##STR2## and PO is an oxypropylene unit, EO is an oxyethylene unit, y is a number in the range of 0 to about 20, z is a number in the range of 0 to about 20, the sum y+z is a number in the range of about 2 to about 20, and R.sub.2 and R.sub.3 are selected, independently, from the group consisting of hydrogen, an alkyl group, an aralkyl group, and an aryl group;R.sub.Type: GrantFiled: November 29, 1991Date of Patent: July 5, 1994Assignee: Miles Inc.Inventors: Gunter Franke, Michael Salvati, Ronald G. Sommer
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Patent number: 5279790Abstract: The present invention provides an analytical test strip for the detection of protein in a biological sample including a novel combination of protein error indicators. The invention includes, in combination, a partially halogenated phenolsulfonephthalein protein error indicator having nitro or nitroso substituent groups in the B and/or C rings and a merocyanine protein error indicator.Type: GrantFiled: November 2, 1992Date of Patent: January 18, 1994Assignee: Miles Inc.Inventors: Paul F. Corey, Angela A. Michaels, Ronald G. Sommer
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Patent number: 5187104Abstract: The present invention provides a novel group of protein error indicators including nitro or nitroso substituent groups in the B and C rings of a partially halogenated triphenylmethane compound.Type: GrantFiled: June 6, 1991Date of Patent: February 16, 1993Assignee: Miles Inc.Inventors: Paul F. Corey, Angela A. Michaels, Lois J. Proud, Michael Salvati, Robert W. Trimmer, Ronald G. Sommer
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Patent number: 5044981Abstract: A communication line plug coupler is for use in a multiline equipment panel which snap fits into an aperture formed through a surface of the panel. The coupler receives at least one communication line plug on each side of the panel providing a primary demarcation point in determining system problems. The coupler comprises a coupler body having a front portion and a rear portion with an RJ11 plug receptacle formed in the front portion and an insert receptacle formed in the rear portion. The front portion is integrally formed with flexible retention means for retaining the coupler in engagement through the aperture formed in the panel. The receptacles are formed in the coupler for positioning removably engagable plugs inserted in each receptacle for electrical engagement therebetween. The coupler is integrally formed as a single piece body of a material such as plastic having insulating characteristics for insulating the coupler from the panel.Type: GrantFiled: April 18, 1990Date of Patent: September 3, 1991Assignee: Reliance Comm/Tec CorporationInventors: Louis Suffi, Ronald G. Sommers
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Patent number: 5045480Abstract: An immobilized hapten reagent for use in a specific binding assay for the determination of a hapten or binding analog thereof in a liquid test sample and methods for preparing and using the immobilized hapten reagent. The immobilized hapten reagent comprises a hapten moiety covalenty linked substantially only to the external surface of a gel particle. The immobilized hapten reagent is prepared by forming a reaction mixture comprising the hapten moiety and the carrier material in a nonswelling solvent wherein the gel particle is substantially impervious to the hapten moiety and wherein an analytically insignificant amount of the hapten moiety is nonspecifically bound to the gel particle. The immobilized hapten reagent is characterized by being substantially stable in aqueous solutions and exhibits an insignificant amount of leakage of the hapten moiety into a liquid test medium.Type: GrantFiled: February 9, 1989Date of Patent: September 3, 1991Assignee: Miles Inc.Inventors: Richard D. Johnson, H.-Volker Runzheimer, Ronald G. Sommer, Kin F. Yip
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Patent number: 4822747Abstract: An immobilized hapten reagent for use in a specific binding assay for the determination of a hapten or binding analog thereof in a liquid test sample and methods for preparing and using the immobilized hapten reagent. The immobilized hapten reagent comprises a hapten moiety covalently linked substantially only to the external surface of a polyacrylamide gel particle. The immobilized hapten reagent is prepared by forming a reaction mixture comprising the hapten moiety and the carrier material in a nonswelling solvent wherein the gel particle is substantially impervious to the hapten moiety and wherein an analytically insignificant amount of the hapten moiety is nonspecifically bound to the gel particle. The immobilized hapten reagent is characterized by being substantially stable in aqueous solutions and exhibits an insignificant amount of leakage of the hapten moiety into a liquid test medium.Type: GrantFiled: December 9, 1986Date of Patent: April 18, 1989Assignee: Miles Inc.Inventors: Richard D. Johnson, H. Volker Runzheimer, Ronald G. Sommer, Kin F. Yip
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Patent number: 4562148Abstract: The invention provides an analytical element and a method for preparing an analytical element for evaluation of a liquid sample with respect to a particular analyte by (a) incorporating a carrier with a composition in a liquid, the composition comprising at least one reagent of an analyte-detecting system, under conditions effective to ionize a reagent migration inhibiting substance, which substance is insoluble in said liquid when in its nonionized form and soluble in said liquid when ionized, and drying the carrier; and then (b) incorporating the carrier of (a) with a second composition in a liquid different from that of (a), the composition comprising the remaining reagents of the analyte-detecting system which are reactive with the at least one reagent of (a) and a reagent migration inhibiting substance which is soluble in said liquid when in its nonionized form, which liquid is effective to prevent reaction of the second composition with the at least one reagent of (a) prior to contact of the element witType: GrantFiled: November 6, 1981Date of Patent: December 31, 1985Assignee: Miles Laboratories, Inc.Inventor: Ronald G. Sommer
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Patent number: 4543335Abstract: A device for the quantitative determination of heparin in mammalian blood plasma, a method for the preparation of such device and a method for determining the plasma's heparin concentration using the device. The device, which is prepared using a freeze-drying technique, comprises a first upper layer of a carrier matrix material containing a buffer, AT-III and thrombin and a second, lower layer of a carrier matrix containing a thrombin sensitive fluorogenic or chromogenic substrate being capable of interacting with thrombin in such a manner that a time-related chemical change detectable by fluorometric or spectrophotometric means takes place when thrombin and the substrate are contacted in a suitable liquid environment.Type: GrantFiled: December 20, 1982Date of Patent: September 24, 1985Assignee: Miles Laboratories, Inc.Inventors: Ronald G. Sommer, Alfred C. Greenquist
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Patent number: 4473639Abstract: Disclosed is a method and device for the quantitative determination of AT-III in mammalian blood plasma. The method involves contacting a plasma sample containing excess heparin with a 3 layered reagent strip comprising:i. a first upper layer of a bibulous material containing thrombin and a buffer;ii. a second lower layer of a bibulous material containing a fluorogenic or chromogenic substrate capable of interacting with thrombin in a time related chemical manner; andiii. a bottom layer of water impermeable material.The chemical change in the strip is determined as a function of time and this change is compared with that obtained in samples containing known amounts of AT-III.Type: GrantFiled: September 15, 1982Date of Patent: September 25, 1984Assignee: Miles Laboratories, Inc.Inventors: Ronald G. Sommer, Alfred C. Greenquist