Abstract: Glycine is indicated to prevent or treat acute or chronic graft rejection, optionally in combination with an immunosuppressant or an immunomodulating agent.

Abstract: Disclosed is a rinse solution for rinsing organs and tissues prior to transplantation. The solution comprises, in one liter of solution: from 2 mM to 50 mM glycine; from 0.12 to 1.2 mM adenosine; monosaccharide, sodium, potassium, calcium and magnesium ions; and water for injection sufficient to make a liter of solution; said solution having a pH of about 6.0 to 7.5 and a concentration of potassium of less than 6 MEQ/L. Methods of making and using the solutions are also disclosed.

Abstract: A method for treating a human having elevated tumor necrosis factor levels by administrating an effective amount of one of the amino acids glycine, alanine, or serine.

Abstract: The invention provides a method for the treatment of endotoxic shock comprising administering to a human or other mammal in need of such a treatment an effective amount of choline for reducing endotoxin-induced injury and mortality and a nutritional composition comprising choline, whereby the composition provides a daily dosage of at least 1.5 g choline, the upper limit being 20 g of choline per day.

Abstract: A method for the inhibition and amelioration of alcholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.

Abstract: The present invention provides, inter alia, use of L-arginine, a precursor of L-arginine and/or physilogically acceptable salts thereof, or of (i) a nitric oxide donor, and/or (ii) a substrate of the nitric oxide synthetase, and/or (iii) a precursor of the said substrate, in the preparation of a medicament or nutritional formulation for the amelioration of micro-circulatory hypo-perfusion, and/or the treatment or prophylaxis of hypoperfusion-reperfusion injury, in patients which have undergone elective surgery, characterized in that the medicament or nutritional formulation is pre-operatively administered to the patient.

Abstract: Composition comprising glycine and/or other amino acids are useful in treating or minimizing the effects of endotoxemia, hypoxia-reperfusion injury and infection.

Abstract: A composition for storing tissue prior to transplantation is disclosed, wherein the tissue storage composition comprises a calcium channel blocker. Also disclosed is a method of storing tissue, comprising contacting the tissue to be stored with an amount of a calcium channel blocker sufficient to reduce tissue injury during storage under conditions such that viability of the tissue is maintained.

Abstract: Disclosed is a rinse for preservation solution for organs and tissues selected for transplantation. The solution can be used at all temperatures from 0.degree. C. to normal body temperature and continues to be protective above 10.degree. C. Methods for preparing organs and tissues preserved in a preservation solution prior to transplant into a recipient are also disclosed.